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2018-463 REAGENT TO LABEL PROTEINS VIA LYSINE ISOPEPTIDE BONDS

Reagent to Label Proteins via Lysine Isopeptide BondsSUMMARYResearchers in the UCLA Department of Chemistry and Biochemistry and the University of Texas-Medical Center, Houston Department of Microbiology and Molecular Genetics have modified the Corynebacterium diphtheriae (C. diphtheriae) sortase enzyme so that it can be used as a bioconjugation reagent...

Published: 9/12/2023 | Inventor(s): Robert Clubb, Brendan Amer, Hung Ton-That, Chungyu Chang, Janine Fu, Scott Mcconnell

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Therapeutics, Therapeutics > Infectious Diseases

Identification of Sortases and Methods of Use

Case 1999-262UCLA has a portfolio of intellectual property on the composition, methods of screening, and methods of use of the sortase-transamidase enzymes, Sortases A and B. BACKGROUNDHospital-borne bacterial infections present a major challenge in patient care due to the rising number of strains resistant to multiple antibiotics in recent years....

Published: 7/19/2023 | Inventor(s): Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Infectious Diseases