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Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)

Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...

Published: 11/15/2024 | Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee

Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

2020-152 Method to Clone Human T Cell Receptors (TCRs) from Single Lymphocytes Based on Functional Profiling

SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to clone human T cell receptors from single lymphocytes. BACKGROUND: Immunotherapy is a growing therapy type for the treatment of disease, especially cancer, by activating or repressing the immune system. One major type...

Published: 11/15/2024 | Inventor(s): Owen Witte, Jami Witte, Pavlo Nesterenko

Keywords(s):

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing

2021-174: TCR ALPHA/BETA SEQUENCES REACTIVE WITH HLA-A*02:01 RESTRCITED EPITOPES WITHIN NSP12 PROTEIN OF SARS-COV-2 VIRUS

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel way to use the sequencing information from T cell mediated immune responses to profile TCR alpha/beta sequences against SARS-CoV-2 virus. This invention has potential to help develop therapeutics or characterize and produce a long-term...

Published: 11/15/2024 | Inventor(s): Owen Witte, Pavlo Nesterenko, Jami Witte

Keywords(s):

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Vaccines, Therapeutics > Immunology And Immunotherapy

Method to Sequence mRNA in Single Cells in Parallel With Quantification of Intracellular Phenotype (UCLA Case No. 2020-884)

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel methodology that enables droplet-based, single-cell sequencing of RNA in parallel with quantification of intracellular phenotype. They performed intracellular staining with subsequent selection of T Cells expressing certain cytokine or transcription...

Published: 11/15/2024 | Inventor(s): Owen Witte, Pavlo Nesterenko, Jami Witte

Keywords(s): Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology