Search Results - owen+witte

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TRP: Generation of Therapeutic Human Anti-TROP2 Extracellular Domain Antibodies (UCLA Case No. 2015-958)

Tangible Research Property (TRP) Contact UCLA Technology Development Group to learn more.

Published: 9/24/2025 | Inventor(s): Owen Witte

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies

Catch Bond-Enhanced Human T Cell Receptors Targeting Prostatic Acid Phosphatase on HLA-A*02:01 (UCLA Case No. 2025-138)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics and Stanford researchers from the Department of Molecular and Cellular Physiology have developed novel enhanced T cell receptors engineered to specifically recognize prostatic acid phosphatase, offering a powerful and precise immunotherapeutic strategy for prostate...

Published: 9/19/2025 | Inventor(s): Owen Witte, Zhiyuan Mao, John Lee, Kenan Christoph Garcia

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)

Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...

Published: 4/14/2025 | Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao

Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy

Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy

Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)

Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...

Published: 7/17/2025 | Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment

Human T-Cell Receptors Targeting Tumor-Enhanced Splicing Epitopes on HLA-A for Small Cell Carcinoma (UCLA Case Nos. 2023-117, 2020-817)

UCLA Researchers in the Department of Microbiology, Immunology, & Molecular Genetics have utilized their previously developed computational method (IRIS), to process and capture small cell carcinoma-specific RNA splicing events in small cell cancer. These events and associated epitopes were then used as the basis for generating new T cell receptors...

Published: 7/31/2025 | Inventor(s): Owen Witte

Keywords(s): alternative splicing, Cancer, prostate cancer, RNA splicing, small cell, small cell cancer, small cell lung cancer, small cell prostate cancer, Targets And Assays

Category(s): Life Science Research Tools

Inhibitory Chimeric Antigen Receptors That Reduce Car-T Cell “On-Target, Off-Tumor” Toxicity (UCLA Case No. 2022-186)

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics, and the Department of Molecular and Medical Pharmacology have recently developed a novel approach which improves the kinetics and specificity of CAR T-cell therapy. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered...

Published: 9/25/2025 | Inventor(s): Owen Witte

Keywords(s): blood cancers, CAR-T cell therapy

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics

Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)

Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...

Published: 7/31/2025 | Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee

Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

2020-152 Method to Clone Human T Cell Receptors (TCRs) from Single Lymphocytes Based on Functional Profiling

SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to clone human T cell receptors from single lymphocytes. BACKGROUND: Immunotherapy is a growing therapy type for the treatment of disease, especially cancer, by activating or repressing the immune system. One major type...

Published: 7/31/2025 | Inventor(s): Owen Witte, Jami Witte, Pavlo Nesterenko

Keywords(s):

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing

Novel Non-Immunogenic Positron Emission Tomography Gene Reporter (UCLA Case No. 2007-474)

Novel Non-Immunogenic Positron Emission Tomography Gene ReporterTech ID: 30321 / UC Case 2007-474-0SUMMARYUCLA researchers in the Department of Pharmacology and Department of Microbiology, Immunology, & Molecular Genetics have developed a novel positron emission tomography reporter gene to preferentially trap radiolabeled deoxycytidine analogs.BACKGROUNDPositron...

Published: 7/31/2025 | Inventor(s): Owen Witte, Caius Radu, Evan Nair-Gill

Keywords(s): Cell Counting/Imaging, Life Science Research Tools, Medical Imaging, PET, Research Methods

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET

Non-Immunogenic Positron Emission Tomography Gene Reporter Systems (UCLA Case No. 2006-709)

Non-Immunogenic Positron Emission Tomography Gene Reporter SystemsTech ID: 30320 / UC Case 2006-709-0SUMMARYUCLA researchers in the Department of Pharmacology and Department of Microbiology, Immunology, & Molecular Genetics have developed a novel dual gene positron emission tomography reporter system for the enhanced labeling of cells in vitro and...

Published: 7/31/2025 | Inventor(s): Owen Witte, Caius Radu

Keywords(s): Cell Counting/Imaging, Life Science Research Tools, Medical Imaging, PET, Research Methods

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