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Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)
Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...
Published: 10/8/2024
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Inventor(s):
Dino Di Carlo
,
Owen Witte
,
Doyeon Koo
,
Zhiyuan Mao
Keywords(s):
Cancer Immunotherapy
,
CAR-T cell therapy
,
Flow Cytometry
,
hydrogel
,
Immunooncology
,
Immunotherapy
,
Peptide
,
single cell analysis
,
T Cell
,
T cell based therapy
Category(s):
Diagnostic Markers > Immunology
,
Life Science Research Tools > Screening Libraries
,
Therapeutics > Immunology And Immunotherapy
Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)
Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...
Published: 11/15/2024
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Inventor(s):
Owen Witte
,
Zhiyuan Mao
,
Jami Witte
,
Pavlo Nesterenko
,
John Lee
Keywords(s):
Cancer
,
cancer antigen
,
Peptide
,
peptides
,
prostate cancer
,
protein
,
t-cells
Category(s):
Therapeutics
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Fast Implementation Of Equally-Sloped Tomography
SummaryDr. Miao and colleagues at UCLA have developed a novel algorithm that quickly processes high quality image reconstruction of data acquired through Equally-Sloped Tomography.BackgroundTomography is an imaging technique that uses cross-sectional images to depict an object. The utility of this technique ranges across medical imaging of the body...
Published: 7/19/2023
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Inventor(s):
Jianwei Miao
,
Benjamin Pooya Fahimian
,
Yu Mao
Keywords(s):
Image Processing
,
Life Science Research Tools
,
Software
,
Software & Algorithms
Category(s):
Software & Algorithms
,
Life Science Research Tools
,
Software & Algorithms > Image Processing
,
Software & Algorithms > Programs