Search Results - patricia+spilman

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2018-200 AMYLOID PRECURSOR PROTEIN-SELECTIVE BACE INHIBITORS (ASBIS) FOR ALZHEIMER’S DISEASE

Amyloid Precursor Protein-Selective BACE Inhibitors for Alzheimer’s DiseaseSUMMARYUCLA researchers in the Department of Neurology have invented novel Alzheimer’s disease (AD) therapeutics that are selective for BACE1 inhibition and cleavage of the amyloid precursor protein (APP) substrate.BACKGROUNDAlzheimer’s disease is characterized...

Published: 7/19/2023 | Inventor(s): Barbara Jagodzinska, Varghese John, Patricia Spilman, Jesus Campagna

Keywords(s): Cns, Life Science Research Tools, Medical Devices and Materials, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers > Targets And Assays, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology

2016-305 New 3D-Exoquant Method for the Analysis of Surface Molecules and Quantification of Tissue-Specific Exosomes in Biological Fluids

SUMMARYUCLA researchers in the Department of Neurology have developed a novel high sensitivity exosome and extracellular vesicle disease detection technology for use in the clinical and research setting. BACKGROUNDDetection of surface biomarkers located on extracellular bodies, such as vesicles and exosomes is of great clinical and research significance...

Published: 7/19/2023 | Inventor(s): Varghese John, Patricia Spilman, Jesus Campagna, Peter Heinzelman, Tina Bilousova

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics)

Category(s): Diagnostic Markers, Platforms > Diagnostic Platform Technologies

2017-772 ALLOSTERIC BACE INHIBITORS FOR TREATMENT OF ALZHEIMER’S DISEASE

Allosteric BACE Inhibitors For Treatment Of Alzheimer’s DiseaseSUMMARYUCLA researchers from the Department of Neurology have discovered a new class of drug candidates for Alzheimer’s disease. These small molecule compounds can specifically inhibit target enzymes to prevent target protein cleavage through an allosteric mechanism, preventing...

Published: 9/5/2023 | Inventor(s): Varghese John, Barbara Jagodzinska, Patricia Spilman, Jesus Campagna, Kanagasabai Vadivel, Michael Jung

Keywords(s): Cns, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology