Search Results - therapeutics+%3e+infectious+diseases

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An Alternative T Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2024-198)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have created a novel T cell redirecting bispecific antibody (TRBA) for treatment of cytomegalovirus (CMV) infection. BACKGROUND: The human cytomegalovirus (CMV) has a seroprevalence of about 60% in the USA and nearly 100% of the population in some parts of the world....

Published: 11/15/2024 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), immunocompromised patients, Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Transplant, Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

Novel Host-Directed Therapeutic Agent to Cure Infectious Diseases (UCLA Case No. 2023-079)

UCLA researchers in Department of Molecular and Medical Pharmacology, in collaboration with Hannover Medical School in Germany, have developed a host-directed therapeutic agent targeting mammalian deoxycytidine kinase to prevent, treat, and even cure any local and systemic infectious diseases in human and animal hosts. BACKGROUND: Many clinically...

Published: 7/30/2024 | Inventor(s): Caius Radu, Evan Abt, Volker Achim Winstel

Keywords(s):

Category(s): Therapeutics > Infectious Diseases

Quercetin as substrate for antiviral treatment against Hepatitis C virus infection (UCLA Case No. 2023-003)

UCLA researchers in the Department of Pathology and Hematology have developed a novel antiviral treatment for Hepatitis C virus based on the metabolic modulating properties of dietary compound Quercetin. BACKGROUND: Hepatitis C virus (HCV) is responsible for 180 million infections worldwide and over 12,000 deaths in the U.S. each year. Despite most...

Published: 5/16/2024 | Inventor(s): Nu Lu

Keywords(s): antivirals, hepatitis, immune metabolism, Inflammation, liver disease

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

Use of Dupilumab for Disseminated Fungal Infection (UCLA Case No. 2019-706)

BACKGROUND: Dupilumab, an immunomodulatory drug that blocks IL-4 signaling, is most commonly used to treat moderate-to-severe atopic dermatitis (a form of eczema) and asthma in both adults and adolescents. While fungal infections, such as coccidioidomycosis, can be potentially treated with immunomodulatory drugs, Dupilumab does not currently have...

Published: 5/14/2024 | Inventor(s): Manish Butte, Maria Garcia-Lloret

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Infectious Diseases

A Potent Short Hairpin RNA (SHRNA734) to Positively Select and Eliminate Genetically Modified Cells (UCLA Case No. 2016-524)

BACKGROUND: Gene therapy strategies to modify human stem cells hold great promise for curing many human diseases. However, previous clinical studies have met with limited success, largely due to the low engraftment of gene modified stem cells. One strategy to overcome this challenge involves engineering stem cells in which HPRT expression is knocked...

Published: 3/8/2024 | Inventor(s): Dong Sung An, Saki Shimizu

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Infectious Diseases

Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/26/2024 | Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

Novel Safe Potent Single Vector Platform Vaccines Against Melioidosis (UCLA Case No. 2023-119)

UCLA researchers in the School of Medicine have developed a novel single-vector platform vaccine for preventing melioidosis, an infection caused by Burkholderia pseudomallei. BACKGROUND: Melioidosis, also known as Whitmore’s disease, is an infectious disease that can infect both humans and animals. The bacterium Burkholderia pseudomallei (Bp)...

Published: 2/21/2024 | Inventor(s): Marcus Horwitz

Keywords(s): Burkholderia pseudomallei, Intracellular Pathogens, Live attenuated vaccine, Melioidosis, Pathogen, Select Agents, Tier 1 Diseases, Vaccines

Category(s): Therapeutics > Infectious Diseases

A T-Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2023-020)

UCLA researchers at the Departments of Medicine and Microbiology Immunology and Molecular Genetics have developed a novel bispecific antibody-based immunotherapy strategy for the treatment of Cytomegalovirus infections. BACKGROUND: The human cytomegalovirus (CMV) is a widespread virus estimated to infect 60% of American adults and nearly 100% of...

Published: 11/15/2024 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

Nrf2 Agonist as Therapeutic Modality to Increase Antiviral Efficacy of Existing Antivirals Against Coronavirus Infections (UCLA Case No. 2022-325)

UCLA researchers in the School of Medicine’s department of Infectious Disease have identified a novel therapeutic approach that can supplement existing FDA approved treatments for SARS-CoV2-2 infections to provide robust treatments against morbidity. BACKGROUND: The World Health Organization reports that as of June 2023, there have been over...

Published: 2/23/2024 | Inventor(s): Theodoros Kelesidis

Keywords(s): Coronavirus, COVID-19, Paxlovid, SARS-CoV-2, Viral Medication

Category(s): Therapeutics > Infectious Diseases

2012-341 Quantum Dot Enabled Detection of Escherichia Coli using a Cell-Phone

Summary: UCLA researchers in the Department of Electrical Engineering have developed a platform that can detect E. coli using a cell phone. Background: Water and food-associated diseases still pose considerable public health threat even in highly industrialized parts of the world, causing significant amount of hospitalizations and deaths every year....

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Hongying Zhu

Keywords(s): Cell Counting/Imaging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Image Processing, Infectious Diseases, Photonics

Category(s): Software & Algorithms > Image Processing, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies, Therapeutics > Infectious Diseases, Optics & Photonics

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