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Search Results - tumor
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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Anti
tumor
Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic
tumor
growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 3/6/2024
|
Inventor(s):
Cun-Yu Wang
,
Jia Lingfei
Keywords(s):
Cancer stem cells
,
Epigenetics
,
Immunooncology
,
Oncology Immunotherapy
,
Tumor
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Gene Therapy And Editing
Anti
tumor
activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)
UCLA researchers have discovered a therapy for anti-PD-1 resistant
tumor
s in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...
Published: 2/15/2024
|
Inventor(s):
Antoni Ribas
Keywords(s):
Colon carcinoma
,
Immune checkpoint blockade
,
Immunotherapy
,
Oncology
,
Oncology (Small Molecules, Peptides and Antibodies)
,
PD-1
,
PD-L1
,
Resistant
tumor
s
,
Signaling pathways
,
Small molecule therapeutics
,
Tumor
Category(s):
Life Science Research Tools
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Oncology > Oncology (Small Molecules)
Novel Method to Group Pixels for Medical Imaging (UCLA Case No. 2022-290)
Summary: UCLA researchers in the Department of Radiological Sciences have developed a new computational pipeline for identifying lesions in MRI data. Background: Prostate cancer is one of the most common cancer types with 12.6% of men diagnosed within their lifetime. Prostate cancer ranks as the 2nd leading cause of cancer-related deaths in the...
Published: 7/31/2023
|
Inventor(s):
Ashley Yeager
Keywords(s):
AI algorithms
,
Algorithm
,
algorithmic cancer detection
,
Cancer
,
cancer detection
,
DICOM
,
multiparametric MRI (mpMRI)
,
prostate cancer
,
Radiology
,
Software & Algorithms
,
Tumor
,
Tumor
Marker
Category(s):
Software & Algorithms
,
Software & Algorithms > Image Processing
,
Software & Algorithms > Digital Health
2023-009: Repurposing Native Cytokine Receptor Signaling for Adoptive T Cell Therapy of Cancer
SUMMARY: UCLA researchers in the Department of Radiation Oncology at the School of Medicine have identified a cytokine receptor endowing adoptively transferred T cells with new functions that enhance the potency of adoptively transferred T cells for the treatment of solid
tumor
s, namely by restoring their functionality in the absence of conditioning...
Published: 7/19/2023
|
Inventor(s):
Anusha Kalbasi
Keywords(s):
Cancer
,
Immunotherapy
,
Tumor
Category(s):
Life Science Research Tools
,
Therapeutics
2021-344 Biopsy-Free In Vivo Virtual Histology of Skin Using Deep Learning
Summary: UCLA researchers in the Departments of Electrical and Computer Engineering & Bioengineering have developed a non-invasive, biopsy-free technique for in vivo virtual histology of skin cancer using deep learning. Background: Tissue biopsies have often been used to diagnose skin cancers in patients. These procedures are generally cumbersome...
Published: 7/19/2023
|
Inventor(s):
Aydogan Ozcan
,
Jingxi Li
,
Yair Rivenson
,
Xiaoran Zhang
,
Philip Scumpia
,
Jason Garfinkel
,
Gennady Rubinstein
Keywords(s):
Artificial Intelligence
,
Biopsy
,
Cancer
,
Confocal Microscopy
,
Diagnostic Test
,
Histology
,
Image Resolution
,
Invasiveness Of Surgical Procedures
,
Melanoma
,
Optics
,
Skin
,
Software
,
Tissue (Biology)
,
Tumor
Category(s):
Software & Algorithms
,
Software & Algorithms > Image Processing
,
Life Science Research Tools
,
Life Science Research Tools > Microscopy And Imaging
,
Electrical > Imaging
,
Medical Devices > Medical Imaging
,
Optics & Photonics