Search Results - cancer+stem+cells

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Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)

Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...

Published: 7/11/2024 | Inventor(s): Michael Jung, Frank Pajonk

Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine

Full Spectrum Computer Vision for Photon Counting CT (Case No. 2024-058)

Summary: Researchers in the Department of Radiological Sciences have developed a machine learning algorithm that processes multispectral photon counting CT data for accurate medical imaging. Background: Photon counting computed tomography (PCCT) is a tremendous engineering advancement, enabling high resolution spectral imaging with myriad applications....

Published: 9/20/2024 | Inventor(s): Matthew Brown, Dieter Enzmann, John Hoffman, Michael Mcnitt-Gray

Keywords(s): AI algorithms, Algorithm, Algorithm Optical Coherence Tomography, algorithmic cancer detection, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, Artificial Neural Network Artificial Neuron, artificial-intelligent materials, Big Data, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, Cancer stem cells, cancer target, Computed tomography, CT, Deep Learning, design software, Digital Pathology, generative artificial intelligence, Genetic Algorithm, Histopathological image analysis, Histopathology, histopathology images, hyperparameter optimization, Image Analysis, Image Processing, lympathic cancers, lymphatic cancer, Medical artificial intelligence (AI), Mesenchymal Stem Cell Derived Cancer Cells, Orthotopic cancer models, Pancreatic cancer, pathology image analysis, Photon counting computed tomography (PCCT), prostate cancer, Radiology, Radiology / Radiomitigation, Software, Software & Algorithms, Software Development Tools, Software-enabled learning

Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics

Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)

UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...

Published: 3/6/2024 | Inventor(s): Cun-Yu Wang, Jia Lingfei

Keywords(s): Cancer stem cells, Epigenetics, Immunooncology, Oncology Immunotherapy, Tumor

Category(s): Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Gene Therapy And Editing

Method for Combined Conditioning and Chemoselection in a Single Cycle (UCLA Case No. 2011-478)

SUMMARY: Researchers at UCLA have developed a highly-efficient technique to engraft and select hematopoietic stem cells directly inside a patient. The invention will improve the fidelity of stem cell transplantations and reduce toxic side effects on patients. BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a mainstay of treatment for...

Published: 11/15/2024 | Inventor(s): Gay Crooks, Robert Schiestl, Katrin Hacke, Akos Szakmary

Keywords(s): blood cancers, Cancer stem cells, Hematopoietic stem cell transplantation, hematopoietic stem cells, lymphatic cancer, stem cell transplantations, Transplant

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Transplant

Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)

UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...

Published: 1/17/2024 | Inventor(s): Serendipity Zapanta Rinonos, Albert Lai

Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology