Search Results - peter+clark

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2021-144 BIOMARKERS OF DRUG TARGET ENGAGEMENT IN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified kinase inhibitors that block glucose consumption and for which [18F]FDG PET can be used as a biomarker, potentially aiding in the early assessment of therapeutic regimen and faster clinical trials.BACKGROUND: Pharmacodynamic biomarkers of drug efficacy...

Published: 9/5/2023 | Inventor(s): Peter Clark, Chiara Ghezzi

Keywords(s): Diagnostic Markers & Platforms, PET

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging > PET, Therapeutics > Oncology

2017-973 Brain Penetrant EGFR Tyrosine Kinase Inhibitors

Brain Penetrant EGFR Tyrosine Kinase InhibitorsSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry, Molecular & Medical Pharmacology, and Neurology have discovered novel anti-tumor compounds for treatment of brain cancer.BACKGROUNDGlioblastoma (GBM) is a devastating form of brain cancer with 12k new diagnoses each year in the...

Published: 7/19/2023 | Inventor(s): David Nathanson, Michael Jung, Peter Clark, Timothy Cloughesy, Gyudong Kim, Jonathan Tsang

Keywords(s): Cns, Oncology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology