Search Results - inflammatory+diseases

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2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 2/14/2025 | Inventor(s): Gay Crooks, Amelie Montel-Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

2019-641 LATE TRANSITION METAL MEDIATED BASE PAIRS AND APPLICATIONS IN BIOTECHNOLOGY AND SYNTHESIS

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of metal-mediated base pair stabilization in vivo, with additional applications in the detection of small nucleic acids and regulation of transition metal catalysis. BACKGROUND:Recent studies of the interactions between transition metals and DNA have led...

Published: 2/14/2025 | Inventor(s): Hosea Nelson

Keywords(s): Catalysts, Chemical Manufacturing & Industrial/Bulk Chemicals, Inflammatory Diseases, Life Science Research Tools, Other, Therapeutics & Vaccines

Category(s): Chemical > Synthesis, Therapeutics > Inflammation And Inflammatory Diseases

2019-876 MAINTAINING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION

UCLA researchers in the Departments of Dentistry and Plastic Surgery have developed a novel suppressor of Npas2 for the regeneration of connective tissues.BACKGROUND:Open wounds of the skin and oral cavity are subject to infection and scarring if not properly closed. Patients may experience a variety of social consequences due to unclosed wounds of...

Published: 2/14/2025 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Hodaka Sasaki, Hiroko Okawa, Lixin Wang

Keywords(s): Dental, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Dental, Therapeutics > Inflammation And Inflammatory Diseases

2019-958 SELECTIVE HDAC INHIBITORS

UCLA researchers in the Department of Chemistry and Biochemistry have synthesized a series of novel hydroxamic acids and derivatives as selective histone deacetylase (HDAC) inhibitors from simple starting materials.BACKGROUND:Histone deacetylase (HDAC) inhibitors are chemical compounds that regulates gene expression by inhibiting histone deacetylases....

Published: 2/14/2025 | Inventor(s): Michael Jung, Jonghoon Kim

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Cns, Gene Editing Systems, Gene Therapy, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Infectious Diseases, Therapeutics > Gene Therapy And Editing, Therapeutics > Inflammation And Inflammatory Diseases, Chemical > Industrial & Bulk Chemicals

Early Prediction of Progression in Idiopathic Pulmonary Fibrosis Using a Single Time Point HRCT Scan (Case No. 2019-731)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a novel single time point high-resolution computed tomography (HRCT) scan method for the early prediction of idiopathic pulmonary fibrosis disease progression. Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that results in scarring of the lungs...

Published: 4/30/2025 | Inventor(s): Grace Hyun Kim, Jonathan Goldin

Keywords(s): CT, Diagnostic Markers & Platforms, Inflammatory Diseases, Life Science Research Tools, Medical Imaging, Microscopy And Imaging

Category(s): Life Science Research Tools > Microscopy And Imaging, Medical Devices > Medical Imaging > CT, Therapeutics > Inflammation And Inflammatory Diseases

2019-468 PERIODONTAL MICROPATCH AND USES THEREOF

INTRODUCTION:UCLA researchers in the Departments of Bioengineering and Dentistry have developed a patch-based drug delivery system for dental applications.BACKGROUND:Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth, and it is estimated that 50% of the U.S. population suffers from some type of periodontal disease....

Published: 2/14/2025 | Inventor(s):

Keywords(s): Dental, Drug Delivery, Inflammatory Diseases, Medical Devices and Materials, Other Polymers

Category(s): Platforms > Drug Delivery > Other Polymers

2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 2/14/2025 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2018-388 METABOLIC REQUIREMENTS FOR ALTERNATIVE MACROPHAGE ACTIVATION

Metabolic Requirements for Alternative Macrophage ActivationSUMMARYUCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that Coenzyme A is a targetable requirement for anti-inflammatory macrophage differentiation.BACKGROUNDA dysregulated immune response is a hallmark of many disease phenotypes. For instance, cancer...

Published: 2/14/2025 | Inventor(s): Steven Bensinger, Ajit Divakaruni, Anne Murphy, Wei Yuan Hsieh

Keywords(s): Autoimmune, Drug Delivery, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

Antitumor Activity Of Sd-101 Alone Or In Combination With A-Pd-1 Therapy In Tumors Resistant To Anti-Pd-1

SummaryUCLA researchers in the Department of Medicine have developed a novel antitumor treatment that works alone or in combination with anit-PD-1 therapy to target interferon signaling-deficient tumors or tumors with alterations in the antigen presentation machinery, that are resistant to anti-PD-1 therapy.BackgroundProgrammed cell death protein 1...

Published: 2/14/2025 | Inventor(s):

Keywords(s): Immunotherapy, Inflammatory Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases

2018-159 Therapeutic Approach to Prevent or Alleviate Drug-, Noise- and Age-Related Hearing Loss

Therapeutic Approach To Prevent Or Alleviate Drug-, Noise- And Age-Related Hearing LossSUMMARYUCLA researchers in the Department of Head and Neck Surgery have developed a novel therapeutic approach to treating hearing loss using inflammation-resolving molecules.BACKGROUNDMore than 350 million people worldwide exhibit some degree of hearing loss, with...

Published: 2/14/2025 | Inventor(s): Jennifer Long, Federico Kalinec

Keywords(s): Drug Delivery, Inflammatory Diseases, Nanoparticles, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Inflammation And Inflammatory Diseases, Platforms > Drug Delivery > Nanoparticles

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