Search Results - christopher+seet

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Gene Modifications to Enhance the Function of PSC-Derived T Cells and NK Cells (UCLA Case No. 2023-129)

UCLA researchers in the Department of Medicine have generated novel pluripotent stem cell derived T cells that exhibit improved survival, expansion, and anti-tumor efficacy for use in cell therapy treatments. BACKGROUND: The Food and Drug Administration has approved several chimeric antigen receptor-T (CAR-T) cell therapies since 2017 to combat lymphoma...

Published: 4/22/2025 | Inventor(s): Christopher Seet

Keywords(s): CAR-T cell therapy, Immunotherapy, pluripotent stem cell (PSC), T-cell engineering

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing

2017-657: Gene Editing Stem Cells for Generating Non-Alloreactive T Cells for Immunotherapy

SUMMARY UCLA researchers in the Department of Pathology and Medicine have developed human stem cells that can be used to generate non-alloreactive, antigen specific T cells for adoptive cell therapy. BACKGROUND Adoptive cell therapy (ACT) with engineered T cells has shown unprecedented potential in the treatment of cancer, infectious diseases,...

Published: 2/14/2025 | Inventor(s): Gay Crooks, Christopher Seet, Amelie Montel-Hagen

Keywords(s): Gene Editing Systems, Gene Therapy, iPS/stem cells, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

A Method for Identifying T Cells with Specific Antigen Reactivity (UCLA Case No. 2019-546)

INTRODUCTION: UCLA researchers in the Department of Medicine have developed a novel method for the isolation of T cells reactive to specific antigens for use in cellular immunotherapy. BACKGROUND:T cell responses to proteins on antigen presenting cells is exceptionally antigen-specific. The identification of antigen-specific T cells, or the sequences...

Published: 2/14/2025 | Inventor(s): Christopher Seet, Gay Crooks

Keywords(s): Autoimmune, Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics > Autoimmune, Therapeutics > Infectious Diseases