Search Results - gay+crooks

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Method for Combined Conditioning and Chemoselection in a Single Cycle (UCLA Case No. 2011-478)

SUMMARY: Researchers at UCLA have developed a highly-efficient technique to engraft and select hematopoietic stem cells directly inside a patient. The invention will improve the fidelity of stem cell transplantations and reduce toxic side effects on patients. BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a mainstay of treatment for...

Published: 11/15/2024 | Inventor(s): Gay Crooks, Robert Schiestl, Katrin Hacke, Akos Szakmary

Keywords(s): blood cancers, Cancer stem cells, Hematopoietic stem cell transplantation, hematopoietic stem cells, lymphatic cancer, stem cell transplantations, Transplant

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Transplant

2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 10/18/2024 | Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

2017-657: Gene Editing Stem Cells for Generating Non-Alloreactive T Cells for Immunotherapy

SUMMARY UCLA researchers in the Department of Pathology and Medicine have developed human stem cells that can be used to generate non-alloreactive, antigen specific T cells for adoptive cell therapy. BACKGROUND Adoptive cell therapy (ACT) with engineered T cells has shown unprecedented potential in the treatment of cancer, infectious diseases,...

Published: 9/5/2023 | Inventor(s): Gay Crooks, Christopher Seet, Amelie Montel Hagen

Keywords(s): Gene Editing Systems, Gene Therapy, iPS/stem cells, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

A Method for Identifying T Cells with Specific Antigen Reactivity (UCLA Case No. 2019-546)

INTRODUCTION: UCLA researchers in the Department of Medicine have developed a novel method for the isolation of T cells reactive to specific antigens for use in cellular immunotherapy. BACKGROUND:T cell responses to proteins on antigen presenting cells is exceptionally antigen-specific. The identification of antigen-specific T cells, or the sequences...

Published: 9/19/2024 | Inventor(s): Christopher Seet, Gay Crooks

Keywords(s): Autoimmune, Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics > Autoimmune, Therapeutics > Infectious Diseases

2015-462 3D Scaffolds for Mesoderm Differentiation

3D Scaffolds For Mesoderm DifferentiationSUMMARYResearchers led by Benjamin Wu from the Departments of Bioengineering and Pathology & Laboratory Medicine have developed an implantable scaffolding that can create hematopoietic stem cells from pluripotent stem cells in vivo.BACKGROUNDHematopoietic stem cells (HSC) produce all cell types of the blood,...

Published: 7/19/2023 | Inventor(s): Gay Crooks, Denis Evseenko, Benjamin Wu, Chee Jia Chin, Eric Tsang

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Inflammation And Inflammatory Diseases