Search Results - medical+devices+%3e+medical+imaging+%3e+pet

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2021-144 BIOMARKERS OF DRUG TARGET ENGAGEMENT IN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified kinase inhibitors that block glucose consumption and for which [18F]FDG PET can be used as a biomarker, potentially aiding in the early assessment of therapeutic regimen and faster clinical trials.BACKGROUND: Pharmacodynamic biomarkers of drug efficacy...

Published: 9/5/2023 | Inventor(s): Peter Clark, Chiara Ghezzi

Keywords(s): Diagnostic Markers & Platforms, PET

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging > PET, Therapeutics > Oncology

2020-163 POSITRON EMISSION TOMOGRAPHY GUIDED DELIVERY OF MITOCHONDRIAL COMPLEX I INHIBITORS

UCLA researchers in the David Geffen School of Medicine Division of Pulmonary and Critical Care Medicine have developed a novel use of the positron emission tomography (PET) tracer [18F]FBnTP to guide the delivery of mitochondrial complex I inhibitors for the treatment of lung cancers.BACKGROUND: The mitochondria are essential regulators of cellular...

Published: 7/19/2023 | Inventor(s): David Shackelford, Saman Sadeghi, Milica Momcilovic

Keywords(s): Diagnostic Markers & Platforms, Imaging, Medical Imaging, PET, Respiratory & Pulmonary

Category(s): Medical Devices > Medical Imaging > PET, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary

2009-357 Second Method For Nucleophilic Fluorination Of Aromatic Compounds With No-Carrier-Added [F-18] Fluoride Ion

Summary UCLA researchers in the Department of Pharmacology have developed a novel aromatic nucleophilic fluorination reaction producing Fluorine-18 [F-18]-labeled aromatic compounds with extensive use in Positron Emission Tomography (PET). Background Positron Emission Tomography (PET or PET scan) is an imaging technique that is used to observe metabolic...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Chemical > Synthesis, Medical Devices > Medical Imaging > PET

2008-664 Novel Reaction Scheme for Synthesis of PET Markers

Background Incorporating positron emitting fluorine-18 into aromatic ring systems plays a very important role in the development of novel biomarkers for use in Positron Emission Tomography (PET). Current methods of preparing biomarkers include nucleophilic fluorine substitution reactions, however the yield obtained by this reaction drops drastically...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET

2012-416 A Novel Positron Emission Tomography Probe for Imaging Liver Disease and Metabolic Imbalance

Summary Researchers at the UCLA Department of Molecular and Medical Pharmacology have developed a new PET probe designed to image ribose metabolism in vivo. Background Positron emission tomography (PET) is a medical imaging technique that follows radioactive tracers to produce a 3D image of functional processes in the body. The most prominent use of...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET

2012-813 Microfluidic Polymer Monoliths for Micro-Scale Preparation of PET Probes

Summary UCLA researchers have developed a platform to perform fluoride ion concentration, solvent exchange, and activation on a continuous flow microfluidic chip. This invention is applicable to Fluorine-18 radiochemistry as well as widely applicable to any flow through capillary platforms or microfluidic platforms, which involve solvent exchange processes,...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET

2013-799 Synthesis of Fluorinated Radiopharmaceuticals via Electrochemical Fluorination

Summary UCLA researchers in the Department of Molecular and Medical Pharmacology have developed efficient and high-yield electrochemical fluorination techniques for aromatic PET tracer synthesis. Background Positron emission tomography (PET) is a powerful diagnostic imaging tool and is increasingly being used to detect and monitor cancer, and cardiovascular...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET

2014-792 Novel Method of Radiofluorination

Summary UCLA researchers have developed a novel method for rapidly radiolabeling molecules with fluorine-18. Background Positron emission tomography (PET) is an extremely powerful diagnostic tool used to visualize functional processes in the body and is commonly used for clinical diagnosis and oncology treatment. A biologically active molecule is first...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET

2019-231: Radiotracer for Synaptic Imaging

UCLA researchers in the Department of Neurology have synthesized a novel radiotracer that selectively identifies functional synapses for monitoring of synaptic loss in Alzheimer’s patients. BACKGROUND: Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that cannot be prevented, cured or slowed. It affects more than 17...

Published: 7/19/2023 | Inventor(s): Varghese John, Mohammad Parvez Alam, Asa Hatami, Daniel Silverman, Saman Sadeghi

Keywords(s): Cns, Diagnostic Markers & Platforms, Medical Imaging, PET

Category(s): Medical Devices > Medical Imaging > PET

2017-210 AUTOMATED PURIFICATION AND FORMULATION MODULE FOR PET PROBES

INTRO SENTENCE: Sofie Biosciences and UCLA researchers from the Department of Molecular and Medical Pharmacology have developed a novel automated module that purifies and formulates radiolabeled compounds intended for medical use. This automation reduces labor cost and radiation exposure, and is widely applicable.TITLE: Automated Purification...

Published: 7/19/2023 | Inventor(s): R. Michael Van Dam, Melissa Moore, Eric Schopf, Brandon Maraglia, Alexander Hsiao

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET

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