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Positron Emission Tomography Guided Delivery of Mitochondrial Complex I Inhibitors (UCLA Case No. 2020-163)
UCLA researchers in the David Geffen School of Medicine Division of Pulmonary and Critical Care Medicine have developed a novel use of the positron emission tomography (PET) tracer [18F]FBnTP to guide the delivery of mitochondrial complex I inhibitors for the treatment of lung cancers.BACKGROUND: The mitochondria are essential regulators of cellular...
Published: 7/17/2025   |   Inventor(s): David Shackelford, Seyed Saman Sadeghi Hosseini, Milica Momcilovic
Keywords(s): Diagnostic Markers & Platforms, Imaging, Medical Imaging, PET, Respiratory & Pulmonary
Category(s): Medical Devices > Medical Imaging > PET, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary
2012-813 Microfluidic Polymer Monoliths for Micro-Scale Preparation of PET Probes
Summary UCLA researchers have developed a platform to perform fluoride ion concentration, solvent exchange, and activation on a continuous flow microfluidic chip. This invention is applicable to Fluorine-18 radiochemistry as well as widely applicable to any flow through capillary platforms or microfluidic platforms, which involve solvent exchange processes,...
Published: 7/17/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices > Medical Imaging > PET
2013-799 Synthesis of Fluorinated Radiopharmaceuticals via Electrochemical Fluorination
Summary UCLA researchers in the Department of Molecular and Medical Pharmacology have developed efficient and high-yield electrochemical fluorination techniques for aromatic PET tracer synthesis. Background Positron emission tomography (PET) is a powerful diagnostic imaging tool and is increasingly being used to detect and monitor cancer, and cardiovascular...
Published: 7/17/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices > Medical Imaging > PET
2014-792 Novel Method of Radiofluorination
Summary UCLA researchers have developed a novel method for rapidly radiolabeling molecules with fluorine-18. Background Positron emission tomography (PET) is an extremely powerful diagnostic tool used to visualize functional processes in the body and is commonly used for clinical diagnosis and oncology treatment. A biologically active molecule is first...
Published: 2/14/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices > Medical Imaging > PET
2017-210 AUTOMATED PURIFICATION AND FORMULATION MODULE FOR PET PROBES
INTRO SENTENCE: Sofie Biosciences and UCLA researchers from the Department of Molecular and Medical Pharmacology have developed a novel automated module that purifies and formulates radiolabeled compounds intended for medical use. This automation reduces labor cost and radiation exposure, and is widely applicable.TITLE: Automated Purification...
Published: 7/17/2025   |   Inventor(s): Michael van Dam, Melissa Moore, Eric Schopf, Brandon Maraglia, Alexander Hsiao
Keywords(s):  
Category(s): Medical Devices > Medical Imaging > PET
2018-727 MILD AND SITE-SELECTIVE 18F-LABELING OF SMALL MOLECULES AND/OR BIOMOLECULES VIA A THIOL-REACTIVE SYNTHON
INTRO SENTENCE:UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a thiol-reactive, site-specific radiolabeling of small molecules and biomolecules for positron emission tomography (PET) molecular imaging. TITLE: Mild and site-selective 18F-labeling of small molecules and/or biomolecules via thiol-reactive synthon...
Published: 7/17/2025   |   Inventor(s): Jennifer Murphy, Gaoyuan Ma
Keywords(s):  
Category(s): Medical Devices > Medical Imaging > PET
2017-450 MICROSCALE DEVICE AND METHOD FOR PURIFICATION OF RADIOPHARMACEUTICALS
Microscale Device and Method for Purification of RadiopharmaceuticalsTech ID: 30310 / UC Case 2017-450-0SUMMARYUCLA researchers from the Departments of Molecular & Medical Pharmacology and Bioengineering have developed a novel method for the purification of radiopharmaceuticals for the on-demand production of positron emission tomography (PET) tracers.BACKGROUNDPositron...
Published: 7/17/2025   |   Inventor(s): Michael van Dam, Seunghyun Noel Ha, Jason Jones, Jimmy Ly, Stephen Liu, Shilin Cheung
Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Imaging, PET
Category(s): Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > PET
2017-380 DEVICE AND METHOD FOR MICROSCALE CHEMICAL REACTIONS
Device and Method for Microscale Chemical ReactionsTech ID: 30291 / UC Case 2017-380-0SUMMARYUCLA researchers in the Departments of Bioengineering and Molecular and Medical Pharmacology have developed a passive microfluidic reactor chip with a simplified design that is less costly than existing microfluidic chips.BACKGROUNDAlthough positron emission...
Published: 7/17/2025   |   Inventor(s): Michael van Dam, Jia Wang
Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Imaging, PET
Category(s): Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > PET
2017-185 METHOD FOR CONCENTRATION AND FORMULATION OF RADIOPHARMACEUTICALS
Method For Concentration And Formulation Of RadiopharmaceuticalsTech ID: 30269 / UC Case 2017-185-0SUMMARYResearchers at the UCLA Department of Medical and Molecular Pharmacology have developed a compact microfluidic device that is able to achieve rapid concentration and/or reformulation of PET tracers after HPLC purification.BACKGROUNDPositron emission...
Published: 7/17/2025   |   Inventor(s): Michael van Dam, Philip Hongsean Chao
Keywords(s): Life Science Research Tools, Medical Imaging, Microfluidics And Mem's, PET
Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET
2016-680 AUTOMATED PHANTOM IMAGE ASSESSMENT TO CONFIRM MACHINE PERFORMANCE AND CALIBRATION
Case No. 2016-680SUMMARYUCLA researchers in the Department of Radiology have developed a method for automated calibration of phantom images.BACKGROUNDPhantom imaging is a routine procedure used in different medical imaging methods such as magnetic resonance imaging (MRI), computerized tomography (CT), positron emission tomography (PET) and ultrasound....
Published: 7/3/2025   |   Inventor(s): Matthew Brown, Michael Mcnitt-Gray, Pechin Lo, Muhammad Wahi Anwar
Keywords(s): CT, Medical Imaging, MRI, PET, Ultrasound
Category(s): Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > CT, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging > PET, Medical Devices > Medical Imaging > Ultrasound
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