Search Results - microfluidics+and+mem%27s

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Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...

Published: 7/29/2025 | Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang

Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping

Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms

A Fabrication Method for High-Precision, Large-Area Acoustic Single-Cell Trapping Devices (Case No. 2025-115)

Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel fabrication method for single-cell trapping devices. Background: Single-cell analysis is critical to personalized medicine, diagnostics, and biomedical research, as it allows researchers to identify, isolate, and expand desired cell subpopulations....

Published: 8/8/2025 | Inventor(s): Pei-Yu Chiou, Jacob Smith

Keywords(s): acoustic manipulation, acoustics, air cavity formation, cell sorting, compliant membrane acoustic patterning (CMAP), Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, high-throughput analysis, large-area arrays, MEMS, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared (NIR) pulsed laser, PDMS, PDMS membranes, single cell analysis, Single cell data, single-cell resolution, single-cell trapping

Category(s): Materials, Materials > Membranes, Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Cell Counting And Imaging, Platforms

2020-810 Mechanical Ventilator With a Fixed Number of Orifice Plates to Generate Constant Flow Paths

Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a constant flow path mechanical ventilator used for the treatment of advanced respiratory diseases, such as acute respiratory distress syndrome (ARDS). Background: Respiratory failure leading to the need for respiratory support...

Published: 7/17/2025 | Inventor(s): Glen Meyerowitz

Keywords(s): Angiogenesis Acute Lung Injury, Cellular Respiration, Cerebrospinal Fluid, Cerebrospinal Fluid Tetramer Retinol Binding Protein, Cerebrospinal Fluid Ventricular System Bleeding, Deoxygenation, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Microfluidics, Ferrofluid, Flow Device, Fluid Dynamics, Fluidics, Half-Reaction Electrolysis Of Water Oxygen Evolution, Intensive-Care Unit Vital Signs, Lung, Lung Pulmonology, Mechanical, Mechanical Engineering, Mechanical Systems, Medical Device, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, Mouse Respiratory System, Oxygen, Oxygen Saturation, Reactive Oxygen Species, Respiratory & Pulmonary, Synovial Fluid

Category(s): Mechanical, Mechanical > Mechanical Systems, Therapeutics > Infectious Diseases > COVID

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

Controllable Emulsification of Point-of-Care Assays Driven by Magnetic Induced Movement of the Fluid

UC Case No. 2016-228SUMMARY:UCLA researchers in the Department of Bioengineering have developed a microfluidic droplet generation technique that only uses magnetic forces to emulsify ferrofluid containing solutions.BACKGROUND: Digital (or droplet) microfluidics is an emerging liquid-handling technology that can be used in a large range of applications...

Published: 7/17/2025 | Inventor(s): Dino Di Carlo, Soroush Kahkeshani

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Monitoring And Recording Systems

Category(s): Life Science Research Tools > Microfluidics And Mems, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies

Mechanisms and Devices Enabling Arbitrarily Shaped, Deep-Subwavelength, Acoustic Patterning

UC Case No. 2019-852SUMMARY:UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a Compliant Membrane Acoustic Patterning (CAMP) technology capable of patterning cells in an arbitrary pattern at a high resolution over a large area. BACKGROUND:Acoustic force has been investigated as a noninvasive, label-free, and...

Published: 7/17/2025 | Inventor(s): Pei-Yu Chiou, Kuan-Wen Tung, Benjamin Wu

Keywords(s): Cell Counting/Imaging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Monitoring And Recording Systems

Category(s): Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies

Redox-Labile Fluorescent Probes and Their Surface Immobilization Methods for the Detection of Metabolites (UCLA Case No. 2019-003)

INTRODUCTION:UCLA researchers in the Department of Molecular and Medical Pharmacology reported a novel single cell assay for profiling lactate production via the use of coupled enzyme reactions on surface-grafted resazurin molecules. BACKGROUND:The upregulation of aerobic glycolysis, known as the Warburg effect, is a hallmark of many cancers....

Published: 7/17/2025 | Inventor(s):

Keywords(s): Life Science Research Tools, Microfluidics And Mem's

Category(s): Life Science Research Tools > Microfluidics And Mems

Methods for Fabricating Modular Hydrogels from Macromolecules with Orthogonal Physico-chemical Responsivity

INTRO SENTENCE:UCLA researchers in the Department of Bioengineering have developed novel methods to construct modular hydrogels with orthogonal porosity and stiffness.BACKGROUND:Hydrogels are an important platform for mimicking extracellular matrix environments in many tissue engineering applications. However, the existing bulk hydrogels typically feature...

Published: 7/17/2025 | Inventor(s):

Keywords(s): Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Musculoskeletal Disease

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Therapeutics > Musculoskeletal Disease

2017-185 METHOD FOR CONCENTRATION AND FORMULATION OF RADIOPHARMACEUTICALS

Method For Concentration And Formulation Of RadiopharmaceuticalsTech ID: 30269 / UC Case 2017-185-0SUMMARYResearchers at the UCLA Department of Medical and Molecular Pharmacology have developed a compact microfluidic device that is able to achieve rapid concentration and/or reformulation of PET tracers after HPLC purification.BACKGROUNDPositron emission...

Published: 7/17/2025 | Inventor(s): Michael van Dam, Philip Hongsean Chao

Keywords(s): Life Science Research Tools, Medical Imaging, Microfluidics And Mem's, PET

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET

2009-438 Localized Droplet Heating with Surface Electrodes in Microfluidic Chips

Localized Droplet Heating with Surface Electrodes in Microfluidic ChipsSUMMARYResearchers at UCLA have developed a low-cost, fully miniaturized lab-on-a-chip system that is capable of localized temperature control without the need to interface with macroscale tubes, thus taking full advantage of miniaturization via microfluidic protocols.BACKGROUNDMicrofluidics...

Published: 7/17/2025 | Inventor(s): CJ Kim, Wyatt Nelson

Keywords(s): Diagnostic Platform Technologies (E.G. Microfluidics), MEMS, Microfluidics And Mem's

Category(s): Life Science Research Tools > Microfluidics And Mems, Electrical > Mems, Platforms > Diagnostic Platform Technologies

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