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2019-008 COMPOSITION OF NY-ESO-1-SPECIFIC T CELL RECEPTORS RESTRICTED ON MULTIPLE MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES

Researchers at the UCLA Department of Microbiology, Immunology, and Molecular Genetics have isolated T cell receptors (TCRs) specific for NY-ESO-1 epitopes presented by four MHC molecules, and developed novel approaches to extend TCR gene therapies targeting NY-ESO-1 using these TCRs.BACKGROUNDThe αβ T cell receptor (TCR) determines the unique...

Published: 7/19/2023 | Inventor(s): Owen Witte, Jami Witte, Michael Bethune, Antoni Ribas, Lili Yang, Jonathan Cebon, Katherine Woods, Ashley Knights

Keywords(s): Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy