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Synthetic Viscoelastic Activating Cells (SynVACs) for T cell engineering (UCLA Case No. 2023-190)
UCLA researchers in the Department of Bioengineering have developed a novel microfluidic device that produces synthetic viscoelastic cells for efficacious therapeutic T cell activation. BACKGROUND: T cell-based therapies, such as the chimeric antigen receptor (CAR) T cell therapy, represents a significant advancement in cancer treatment, particularly...
Published: 3/6/2024
|
Inventor(s):
Zeyang Liu
,
Song Li
,
Lili Yang
,
Yan-Ruide Li
Keywords(s):
CAR-T cell therapy
,
Synthetic antigen presenting cells (SynVACs)
,
T Cell
,
T cell based therapy
,
T-cell activation
,
T-cell engineering
,
t-cells
Category(s):
Therapeutics > Oncology
New Small Molecules for Stable and Efficient Organic Photovoltaics (UCLA Case No. 2023-086)
Summary: UCLA researchers in the Department of Materials Science and Engineering have developed a novel molecule for organic photovoltaics, photodetectors, organic field effect transistors, and other relevant applications. Background: Among all competing photovoltaic technologies, the organic photovoltaics (OPVs) market is likely to grow the fastest,...
Published: 12/8/2023
|
Inventor(s):
Yang Yang
,
Dong Meng
Keywords(s):
Concentrated Solar Power
,
Concentrated Solar Power Chemical Engineering
,
energy conversion
,
energy conversion applications
,
energy recycle
,
interfacial layer
,
Methods Of Detecting Extrasolar Planets
,
multi-junction tandem devices
,
near-infrared
,
organic field effect transistors
,
organic photo detector
,
organic photovoltaics
,
Organic Solar Cell
,
perovskite devices
,
perovskite solar cell
,
Polymer Solar Cell
,
rganic light-emitting diodes
,
Solar Cell
,
Solar Cell Metamaterial
,
Solar Cell Molecular Electronics
,
Solar Energy
,
Thin Film Solar Cell
,
transparent OPVs
,
ultra-narrow bandgap
Category(s):
Electrical
,
Electrical > Electronics & Semiconductors
,
Materials > Functional Materials
,
Energy & Environment > Energy Generation > Solar
2023-043: Enhanced Gamma Delta T Cells for Immunotherapy
SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel platform to generate potent, high quality Vδ2 T cells at scale for use in cancer immunotherapies. BACKGROUND: With rising cases of cancer in the world, immunotherapies have emerged as a promising and potentially effective therapeutic...
Published: 8/14/2023
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Inventor(s):
Lili Yang
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
Alleviating GvHD Using Engineered INKT Cells (UCLA Case No. 2023-019)
SUMMARY: Researchers in UCLA’s Department of Microbiology, Immunology & Molecular Genetics have developed an off-the-shelf cell therapy method for reduction of Graft vs Host Disease (GvHD) following hematopoietic stem cell transplantation. This approach uses engineered third-party iNKT’s to ameliorate severity of GvHD without negatively...
Published: 2/15/2024
|
Inventor(s):
Lili Yang
Keywords(s):
Hematology
,
Stem-Cell Therapy
,
T Cell
,
Therapeutics & Vaccines
Category(s):
Therapeutics
,
Therapeutics > Hematology
2022-209 Modulating Heterointerface Energetics for Operationally Stable Perovskite Solar Cells
Summary: UCLA researchers in the Department of Material Science and Engineering have developed an innovative and low-cost process that increases the stability of perovskite solar cells. Background: Perovskite Solar Cells (PSCs) are a rather new but growing technology for the efficient conversion of solar light to electricity. Most conventional silicon-based...
Published: 8/4/2023
|
Inventor(s):
Yang Yang
,
Shaun Tan
,
Tianyi Huang
Keywords(s):
Cell Surface Receptor
,
Compressed Air Energy Storage
,
Concentrated Solar Power
,
Concentrated Solar Power Chemical Engineering
,
Doping (Semiconductor)
,
Electronics & Semiconductors
,
Energy & Water
,
Energy Balance (Biology)
,
Energy Density
,
Energy Density Boiling Point
,
Energy Density Silicide
,
Energy Density Strong Interaction
,
Energy Efficiency
,
Energy Generation & Storage
,
Energy Generation, Transmission, or Storage
,
Energy Harvesting
,
Energy Harvesting Evaporation
,
Energy Management System
,
Energy Recycling
,
Energy Security
,
Exosome (Vesicle) Surface Enhanced Raman Spectroscopy
,
Fermi Energy
,
FÂorster Resonance Energy Transfer
,
Free Surface
,
Methods Of Detecting Extrasolar Planets
,
Microelectronics Semiconductor Device Fabrication
,
Organic Semiconductor
,
Organic Solar Cell
,
Perovskite Lead(II) Iodide
,
Polymer Solar Cell
,
Power Transmission
,
Renewable Energy
,
Semiconductor
,
Semiconductor Device
,
Semiconductor Device Fabrication
,
Semiconductor Ohmic Contact
,
Semiconductor Risk Assessment
,
Semiconductor Sapphire
,
Semiconductors
,
Silicon Working Electrode Perovskite (Structure)
,
Solar Cell
,
Solar Cell Metamaterial
,
Solar Cell Molecular Electronics
,
Solar Energy
,
Specific Surface Area
,
Stroke Geriatrics Energy Accounting Local Area Network
,
Surface Charge
,
Surface Conductivity
,
Surface Enhanced Raman Spectroscopy
,
Surface Micromachining
,
Surface Modification
,
Surface Plasmon Polaritons
,
Surface Plasmon Resonance
,
Surface Tension
,
Thermal Energy Storage
,
Thin Film Solar Cell
,
Vertical-Cavity Surface-Emitting Laser
,
Vertical-External-Cavity Surface-Emitting-Laser
,
zzenergy storage
,
zzsemiconducting materials
Category(s):
Electrical
,
Electrical > Electronics & Semiconductors
,
Materials
,
Materials > Semiconducting Materials
,
Energy & Environment > Energy Generation > Solar
2022-216 Electrode for Rechargeable Batteries that Resists Dendrite Growth
Summary: UCLA researchers in the Department of Material Science and Engineering have developed electrodes for rechargeable batteries which resist dendrite growth. Background: Rechargeable batteries have attracted attention due to their wide array of applications and environmental benefits. Rechargeable metal-ion batteries, such as lithium-ion batteries,...
Published: 7/19/2023
|
Inventor(s):
Yang Yang
,
Xiaochun Li
Keywords(s):
Alloy
,
Dendrite
,
Electrode
,
Lithium Battery
,
Lithium-Ion Battery
,
Nanoelectronics
,
Nanoparticle
,
Rechargeable Battery
,
Rechargeable Battery Thermal Conductivity
Category(s):
Materials > Semiconducting Materials
,
Energy & Environment > Energy Efficiency
,
Energy & Environment > Energy Storage
,
Electrical > Electronics & Semiconductors
,
Energy & Environment > Energy Storage > Batteries
2019-610 MONOAMINE OXIDASE BLOCKADE THERAPY FOR TREATING CANCER THROUGH REGULATING ANTITUMOR T CELL IMMUNITY and 2019-611 MONOAMINE OXIDASE BLOCKADE THERAPY FOR TREATING CANCER THROUGH REGULATING TUMOR ASSOCIATED MACROPHAGES (TAMS)
SUMMARY UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics identified MAO-A as a drug target and demonstrated repurposing an old antidepressant MAOI for use in combination with cancer immunotherapy methods. BACKGROUND: Monoamine Oxidase A (MAO-A) is a protein of myriad functions relating to neurotransmitter homeostasis...
Published: 9/5/2023
|
Inventor(s):
Lili Yang
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology (Small Molecules)
2019-611 MONOAMINE OXIDASE BLOCKADE THERAPY FOR TREATING CANCER THROUGH REGULATING TUMOR ASSOCIATED MACROPHAGES (TAMS)
SUMMARYMonoamine oxidase A (MAO-A) is postulated to play a critical role in regulating tumor associated macrophages (TAMs) polarization and TAM-induced/dependent immune response. Inhibition of MAO-A serves as a novel therapeutic target to prevent TAM polarization and -induce a robust antitumor immune response.BACKGROUNDTAMs are prominent metastasis...
Published: 9/5/2023
|
Inventor(s):
Lili Yang
Keywords(s):
Category(s):
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
2019-994 Targeted Drug Delivery with Near-IR Light
SUMMARY UCLA researchers in the Department of Materials Science and Engineering have developed a targeted drug delivery platform that can release drugs upon exposure to near-infrared light. BACKGROUND Stimuli-responsive delivery of drugs is an effective way to achieve spatially and temporally controlled drug release. Various stimuli-responsive...
Published: 7/19/2023
|
Inventor(s):
Yang Yang
,
Dong Meng
Keywords(s):
Category(s):
Electrical
,
Chemical
,
Medical Devices > Medical Imaging
,
Platforms > Drug Delivery
,
Medical Devices > Medical Imaging > Fluorescence
,
Chemical > Chemical Sensors
,
Optics & Photonics
Perovskite Technologies
Yang Yang Group Website: http://yylab.seas.ucla.edu/ UC Case Nos. 2015-556, 2018-019, 2022-209 ----- Modulating Heterointerface Energetics for Operationally Stable Perovskite Solar Cells (UCLA Case No. 2022-206) Researchers at UCLA have developed a novel fabrication approach that stabilizes the surface of perovskite solar cells without hindering...
Published: 8/31/2023
|
Inventor(s):
Yang Yang
Keywords(s):
Category(s):
Materials > Composite Materials
,
Materials > Functional Materials
,
Materials > Semiconducting Materials
,
Chemical > Polymers
,
Electrical > Electronics & Semiconductors
,
Electrical > Electronics & Semiconductors > Thermoelectrics
,
Energy & Environment > Energy Generation > Solar
,
Energy & Environment > Energy Storage
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