Search Results - donald+kohn

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Augmentations to Lentiviral Vectors to Increase Expression (UCLA Case No. 2019-616)

UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. BACKGROUND: Sickle cell disease (SCD) is one of the...

Published: 8/14/2024 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Life Science Research Tools, Therapeutics > Genetic Diseases

2020-889 293T PACKAGING CELLS WITH TARGETED GENE KNOCKOUTS THAT IMPROVE LENTIVIRAL VECTOR TITERS

INTRODUCTIONUCLA researchers in the Department of Microbiology, Immunology, & Molecular Genetics have found that the knockout of four host cell antiviral factors could increase lentiviral titers, allowing the potential to reduce common off target toxicities of gene therapy while lowering the cost of treatment manufacturing. BACKGROUNDGene therapy...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Cell Lines, Therapeutics, Therapeutics > Gene Therapy And Editing

Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies

UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...

Published: 1/23/2024 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing

2021-070 SARS-COV-2 SPIKE GLYCOPROTEIN FOR VIRUS GENERATION AND PSEUDOTYPING

SUMMARYUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel lentiviral vector encapsulated/coated with the spike (S) glycoprotein from novel SARS-CoV-2 virus. The novel lentiviral vector not only maintains the high infectivity seen in the widely used d19 spike pseudotype – which removes the...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s):

Category(s): Life Science Research Tools > Plasmids/Vectors, Therapeutics > Infectious Diseases

2019-870 GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM CELLS (XHIM)

Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells. BACKGROUND:Hematopoietic stem cells (HSCs)—stem cells that give rise to...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s): Gene Editing Systems, Gene Therapy, Genetic Disease, Hematology, Immunotherapy, iPS/stem cells, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2016-290 TRANSIENT EXPRESSION OF BCL-2 TO AMELIORATE CYTOTOXICITY OF GENE MODIFICATION REAGENTS IN STEM CELLS.

Transient Expression Of BCL-2 To Ameliorate Cytotoxicity Of Gene Modification Reagents In Stem CellsSUMMARYResearchers at the UCLA Department of Microbiology, Immunology and Molecular Genetics have developed methods for efficient gene editing in stem cells by increasing the level of apoptosis regulator BCL-2.BACKGROUNDEngineered nucleases, such as zinc...

Published: 7/19/2023 | Inventor(s): Donald Kohn, Carmen Bjurstroem

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing

2018-862 GENERATION OF MINIMAL ENHANCER ELEMENTS USING MASSIVELY PARALLEL REPORTER ASSAYS

SummaryUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin.BackgroundSickle cell disease (SCD) is one of the...

Published: 7/19/2023 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan, Aaron Cooper

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing