Search Results - john+chute

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2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 7/19/2023 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2015-365 TARGETING PROTEIN TYROSINE PHOSPHATASE-SIGMA TO AUGMENT HEMATOPOIETIC RECONSTITUTION

Targeting Protein Tyrosine Phosphatase-Sigma to Augment Hematopoietic ReconstitutionSUMMARYUCLA researchers from the Department of Medicine have developed a novel technique for inducing increased hematopoietic recovery after HSC transplantation by targeting the protein tyrosine phosphatase-sigma (PTP-sigma) pathway.BACKGROUNDReceptor tyrosine kinases...

Published: 7/19/2023 | Inventor(s): John Chute

Keywords(s): Hematology, Life Science Research Tools, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Hematology

Targeted Inhibition of Human Multiple Myeloma

Case 2018-175UCLA researchers in the Department of Medicine have discovered a novel mechanism involving Eph receptor/ephrin ligand interaction, that regulates human multiple myeloma growth and repopulation in vivo.BACKGROUNDMultiple myeloma (MM) is a plasma cell malignancy often accompanied by bone osteolytic lesions. Despite standard care with high...

Published: 7/19/2023 | Inventor(s): John Chute, Joshua Sasine

Keywords(s): Hematology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Hematology