Search Results - life+science+research+tools+%3e+plasmids%2fvectors

7 Results

Sort By:

Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies

UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...

Published: 1/23/2024 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing

2021-070 SARS-COV-2 SPIKE GLYCOPROTEIN FOR VIRUS GENERATION AND PSEUDOTYPING

SUMMARYUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel lentiviral vector encapsulated/coated with the spike (S) glycoprotein from novel SARS-CoV-2 virus. The novel lentiviral vector not only maintains the high infectivity seen in the widely used d19 spike pseudotype – which removes the...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s):

Category(s): Life Science Research Tools > Plasmids/Vectors, Therapeutics > Infectious Diseases

2019-863 METHODS CONCERNING ONGOING TREATMENT FOR CANCER

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel biomarker detection method for circulating blood cell-free RNA. BACKGROUND: Approximately 39% of men and women will be diagnosed with cancer at some point during their lifetimes. Circulating tumor cell-free DNA (cfDNA) is being increasingly used...

Published: 7/19/2023 | Inventor(s): Matteo Pellegrini, Eri Srivatsan

Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Oncology

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Diagnostic Markers, Platforms > Drug Delivery > Nucleic Acids

2018-749 A METHOD TO DISTINGUISH DIFFERENT RETROVIRAL VECTORS DURING INTEGRATION SITE ANALYSIS

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel gene therapy vector identifying method, capable of screening toxicities of combination therapies.TITLE: A Method to Distinguish Different Retroviral Vectors During Integration Site Analysis BACKGROUND: Many diseases originate from defective...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Gajendra Suryawanshi, Sanggu Kim

Keywords(s): Gene Editing Systems, Gene Therapy, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Therapeutics, Therapeutics > Gene Therapy And Editing

A Codon-Optimized Lentiviral Vector For Stem Cell Reprogramming (UCLA Case No. 2014-014)

A Codon-Optimized Lentiviral Vector For Stem Cell ReprogrammingSUMMARYUCLA researchers in the Department of Medicine and the Department of Surgery have developed a novel lentiviral vector that expresses a codon-optimized sequence of a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 as well as a positron emission tomography (PET)...

Published: 2/14/2024 | Inventor(s): Antoni Ribas, Richard Koya, Thinle Chodon

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Immunotherapy, iPS/stem cells, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2018-862 GENERATION OF MINIMAL ENHANCER ELEMENTS USING MASSIVELY PARALLEL REPORTER ASSAYS

SummaryUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin.BackgroundSickle cell disease (SCD) is one of the...

Published: 7/19/2023 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan, Aaron Cooper

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing

Plod3-Targeted Anti-Cancer Treatment

UCLA Case No. 2019-281 Summary UCLA researchers in the department of Dentistry have developed a novel anti-cancer treatment that directly targets enzyme expression necessary to sustain cancer growth. Background The incidences of cancer diagnosis in the United States is reported to grow continually in the next decade. While there are a growing...

Published: 7/19/2023 | Inventor(s): Shen Hu, Li Cui

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology