Search Results - plasmids+%2f+vectors

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Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies

UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...

Published: 1/23/2024 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing

2019-880 ZIKA VIRUS-BASED ONCOLYTIC THERAPY FOR BRAIN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel zika virus-based oncolytic therapy to treat brain cancer.BACKGROUND: Glioma is a type of brain tumor that accounts for 80% of all primary malignant brain tumors. Standard therapy for high-grade glioma requires a combination of surgical resection, radiation...

Published: 9/12/2023 | Inventor(s): Vaithilingaraja Arumugaswami, David Nathanson

Keywords(s): Cns, Drug Delivery, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Oncology, Oncology Immunotherapy, Plasmids / Vectors, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Diagnostic Markers > Immunology, Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy

2018-749 A METHOD TO DISTINGUISH DIFFERENT RETROVIRAL VECTORS DURING INTEGRATION SITE ANALYSIS

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel gene therapy vector identifying method, capable of screening toxicities of combination therapies.TITLE: A Method to Distinguish Different Retroviral Vectors During Integration Site Analysis BACKGROUND: Many diseases originate from defective...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Gajendra Suryawanshi, Sanggu Kim

Keywords(s): Gene Editing Systems, Gene Therapy, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Therapeutics, Therapeutics > Gene Therapy And Editing

A Codon-Optimized Lentiviral Vector For Stem Cell Reprogramming (UCLA Case No. 2014-014)

A Codon-Optimized Lentiviral Vector For Stem Cell ReprogrammingSUMMARYUCLA researchers in the Department of Medicine and the Department of Surgery have developed a novel lentiviral vector that expresses a codon-optimized sequence of a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 as well as a positron emission tomography (PET)...

Published: 2/14/2024 | Inventor(s): Antoni Ribas, Richard Koya, Thinle Chodon

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Immunotherapy, iPS/stem cells, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2018-862 GENERATION OF MINIMAL ENHANCER ELEMENTS USING MASSIVELY PARALLEL REPORTER ASSAYS

SummaryUCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin.BackgroundSickle cell disease (SCD) is one of the...

Published: 7/19/2023 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan, Aaron Cooper

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing