Search Results - david+nathanson

6 Results

Sort By:

Synthetic Lethality of IR with ABBV-155 in Glioblastoma (GBM) (UCLA Case No. 2021-232)

UCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that irradiation therapy can be combined with an antibody drug conjugate to form a novel therapeutic strategy to treat and extend survival of glioblastoma patients. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain...

Published: 8/28/2024 | Inventor(s): David Nathanson

Keywords(s): Antibody-Drug Conjugate, Apoptosis, Brain cancer, Cancer, Glioblastoma, irradiation

Category(s): Therapeutics > Oncology

Integrated Molecular and Lipidomic Analysis of Glioma Tumors Identifies Therapeutic Vulnerabilities (UCLA Case No. 2023-210)

UCLA researchers in the Department of Molecular and Medical Pharmacology have uncovered a novel therapeutic target for Glioblastoma leveraging an extensive lipidomic and transcriptomic database. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain Tumor Society predicted that over 14,000 people in the United...

Published: 9/25/2024 | Inventor(s): David Nathanson

Keywords(s): Brain cancer, Brain Tumor, cancer target, cell death, ferroptosis, Glioblastoma, lipidomics

Category(s): Therapeutics > Oncology

Targeting the Intrinsic Apoptotic Machinery in Glioblastoma Multiforme (GBM) (UCLA Case No. 2020-446)

UCLA researchers in the Department of Molecular and Medical Pharmacology identified the mechanisms of apoptotic resistance in glioblastoma multiforme (GBM) and developed a novel therapy to treat GBM. BACKGROUND: Glioblastoma (GBM) is the most aggressive form of brain tumor. Therapeutic options for GBM are limited and suboptimal. Treatment usually...

Published: 2/16/2024 | Inventor(s): David Nathanson

Keywords(s): anti-apoptotic inhibitor, Anti-apoptotic pathway, Apoptosis, Brain Tumor, Glioblastoma, irradiation, p53, temozolomide

Category(s): Therapeutics > Oncology

Identification of a Platform to Identify Tumor-Specific T Cell Receptors (UCLA Case No. 2022-082)

SUMMARY: Researchers from UCLA’s Department of Neurosurgery and Pharmacology have developed a rapid discovery platform for the identification of tumor-specific T cell receptors to aid in more personalized and potent immunotherapy for glioblastoma. BACKGROUND: Over the past several years, immunotherapy, or therapies that enlist and strengthen...

Published: 5/20/2024 | Inventor(s): Robert Prins, Alexander Lee, Lu Sun, David Nathanson

Keywords(s):

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

Targeted Neoantigen Vaccination in H3G34R/V Glioma (UCLA Case No. 2021-008)

UCLA researchers in the Departments of Neurosurgery and Microbiology, Immunology, and Molecular Genetics have developed an immunotherapy treatment methodology for H3G34R/V high-grade glioma, providing an ability to be adapted toward a wide range of similar tumors.BACKGROUND:Over 3000 gliomas and other forms of brain cancer are diagnosed in children...

Published: 5/4/2024 | Inventor(s): Anthony Wang, Geoffrey Owens, Yi Xing, Robert Prins, Linda Liau, David Nathanson

Keywords(s): Immunotherapy, Oncology, Oncology Immunotherapy

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

2019-880 ZIKA VIRUS-BASED ONCOLYTIC THERAPY FOR BRAIN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel zika virus-based oncolytic therapy to treat brain cancer.BACKGROUND: Glioma is a type of brain tumor that accounts for 80% of all primary malignant brain tumors. Standard therapy for high-grade glioma requires a combination of surgical resection, radiation...

Published: 9/12/2023 | Inventor(s): Vaithilingaraja Arumugaswami, David Nathanson

Keywords(s): Cns, Drug Delivery, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Oncology, Oncology Immunotherapy, Plasmids / Vectors, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Diagnostic Markers > Immunology, Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy