Search Results - therapeutics+%3e+ophthalmology

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Intrastromal Lamellar Keratoprosthesis (Artificial Cornea) (Case No. 2025-177)

Summary: UCLA researchers in the Department of Ophthalmology have developed an intrastromal artificial cornea implant designed to enhance biointegration and effectively restore vision. Background: Corneal opacities are among the top five causes of blindness worldwide. For patients who are not candidates for conventional corneal transplantation, keratoprosthesis...

Published: 6/16/2025 | Inventor(s): Seyed Reza Ghaffari Dehkharghani, Anthony Aldave

Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, biomedical sensors, diseases of the eye, eye disease, eye motion, eye movement disorders, Eye Surgery, eye tracking, Glaucoma, macular corneal dystrophy, Macular Degeneration, Medical Device, Medical Imaging Eyepiece, on-eyelid sensor, Ophthalmic antibiotics, Ophthalmology, Other Polymers, Polymers, Prosthetics, Transplant, Transplant Rejection, transplant surgery

Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Ophthalmology

Saliva Anti-SSA/Ro IgA1 Differentiates Sjögren’s from Non-Sjögren’s Syndrome Patients (UCLA Case No. 2023-292)

UCLA researchers in the Department of Dentistry have developed a novel methodology to accurately differentiate patients with Sjögren’s Disease from non-Sjögren’s Disease patients by monitoring saliva IgA1 forms, enabling more accurate tracking of disease progression. BACKGROUND: The presence and detection of autoantibodies within...

Published: 3/14/2025 | Inventor(s): David Wong

Keywords(s):

Category(s): Therapeutics > Autoimmune, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Ophthalmology

Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

Recombinant Adeno-Associated Virus 8 Human Solute Carrier Family 4 Member 11 (AAV8-hSLC4A11) for Congenital Hereditary Endothelial Dystrophy (CHED) (UCLA Case No. 2025-096)

UCLA researchers from the Department of Ophthalmology have developed a novel gene therapy method to treat Congenital Hereditary Endothelial Dystrophy. BACKGROUND: Congenital Hereditary Endothelial Dystrophy (CHED) is a rare autosomal recessive disease that affects corneal endothelial cells, which can lead to blindness if left untreated. CHED is more...

Published: 2/25/2025 | Inventor(s): Anthony Aldave

Keywords(s): Gene Therapy

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing

Intravitreal Injection Device (Case No. 2024-136)

Summary: Researchers in the Department of Ophthalmology at UCLA have developed an intravitreal injection device for safer and more precise injections. Background: Intravitreal injections are vital for treating sight-threatening retinal conditions like age-related macular degeneration and diabetic macular edema. These conditions rely heavily on accurate...

Published: 2/28/2025 | Inventor(s): Taras Gout, Robert Goldberg

Keywords(s): diseases of the eye, Eye Surgery, Macular Degeneration, Ophthalmic antibiotics, Ophthalmology

Category(s): Medical Devices > Surgical Tools, Therapeutics > Ophthalmology, Medical Devices > Hospital Systems

CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)

UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...

Published: 2/14/2025 | Inventor(s): Wenlin Zhang, Anthony Aldave

Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing

Anti-Inflammatory Drug Eluting Patches for Treatment of Ocular Injuries (UCLA Case No. 2022-156)

UCLA researchers in Department of Chemical and Biomolecular Engineering developed a visible light crosslinkable hydrogel-based drug delivery platform that can achieve sustainable release of anti-inflammatory drug molecules to address unmet need of drug bioavailability in ocular injury treatment. BACKGROUND: The Centers for Disease Control and Prevention...

Published: 2/14/2025 | Inventor(s): Nasim Annabi

Keywords(s): eye disease, gelpatch, hyaluronic acid, micelles, Nanoparticles, ocular, ocular inflammation, Ophthalmic antibiotics, Ophthalmology

Category(s): Therapeutics > Ophthalmology

System and Methods for Fluidic Control in Ophthalmic Procedures (Case No. 2024-229)

Summary: Researchers in the Mechanical Engineering Department at UCLA developed an innovative mechatronic system that can perform fast and accurate pressure regulation during cataract surgeries. Background: Despite being generally safe and successful, cataract surgery has a complication rate of about 6%, which is concerning given the high volume...

Published: 2/14/2025 | Inventor(s): Tsu-Chin Tsao, Yuting Lai, Aya Barzelay Wollman

Keywords(s): biomedical sensors, Intraocular Lens , Ophthalmology, Robotic Surgery

Category(s): Mechanical > Instrumentation, Medical Devices > Hospital Systems, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology

Assistive Device to Aid in Identification and Use of Medications (UCLA Case No. 2022-213)

Summary: Researchers in the UCLA Stein Eye Institute have developed a medication assistive device to aid in distinguishing medication bottles and administering medications on the correct schedules for patients, especially those with visual impairment. Background: Many ophthalmic conditions are treated with eye drop medications. These treatments...

Published: 2/14/2025 | Inventor(s): Edmund Tsui, Jie Deng, Holly Huang, Jeff Li, Hyeongtaek Nam, Brian Wu

Keywords(s): 3D Printing, Hospital Systems And Devices, Medical Devices and Materials, Monitoring And Recording Systems, Ophthalmology, Therapeutics & Vaccines

Category(s): Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology

In Vivo Biomarkers of Human Limbal Stem Cell Function (UCLA Case No. 2022-153)

SUMMARY: UCLA researchers in the Department of Ophthalmology have identified novel in vivo biomarkers of limbal stem cell function to accurately diagnose and stage limbal stem cell deficiency. BACKGROUND: The cornea, which is the main part of the eye that is responsible for the production of clear vision, is protected from microbes and fluids by the...

Published: 7/2/2025 | Inventor(s): Sophie Deng

Keywords(s):

Category(s): Diagnostic Markers, Therapeutics > Ophthalmology

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