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Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

Electrical Stimulation for Acute Stroke (Case No. 2020-787)

Summary: Researchers at the UCLA Department of Neurology have developed an individualized method of delivering non-invasive electrical stimulation to treat acute human ischemic stroke. Background: Stroke is a leading cause of mortality and morbidity across the world. Over 80% of strokes are ischemic due to blockage of blood vessels, causing a low...

Published: 2/14/2025 | Inventor(s): Mersedeh Bahr Hosseini, Jeffrey Saver, Marom Bikson

Keywords(s): Acute ischemic stroke, CNS Rehabilitation, Electrical, Electrical Engineering, Electrical stimulation, Neurocognitive, Neuroimaging, Neurointervention, neurological disorders, Neurology, Neuromodulation, Neuron, Neuropathology, Neuropsychological Test, neuroscience, Neurostimulation, Neurosurgery, soft electrical circuits, Stroke, Stroke Geriatrics Energy Accounting Local Area Network, stroke rehabilitation, stroke therapeutics, Transcutaneous Electrical Nerve Stimulation

Category(s): Electrical, Electrical > Flexible Electronics, Medical Devices, Medical Devices > Cardiac, Medical Devices > Hospital Systems

2020-839 Endovascular Transvascular (Transmural) Neuromodulation Technique

SUMMARY: UCLA researchers in the Department of Neurosurgery have developed an endovascular method to deliver pharmaceutical agents with various physical properties (e.g. liquids, gels, solids) across the wall of a vessel directly to the nervous system tissue. BACKGROUND: Portions of the nervous system, such as the autonomic ganglia and associated...

Published: 2/14/2025 | Inventor(s): Geoffrey Colby, Michael Dacey, Jeffrey Ardell

Keywords(s): Cardiovascular, Neurology, Neuromodulation, Neuron, Neurostimulation, Neurosurgery, Peripheral Vascular Disease

Category(s): Medical Devices > Neural Stimulation, Medical Devices > Surgical Tools