Search Results - therapeutics+%3e+stem+cells+and+regenerative+medicine

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Identification of a Factor That Rescues Dysregulated Endocytosis in Cultured Human Hematopoietic Stem Cells (UCLA Case No. 2023-051)

UCLA researchers in the Departments of Molecular, Cell & Developmental Biology have developed a novel method to enhance the function of hematopoietic stem cells (HSCs) to improve the transplantability of ex vivo expanded human HSCs in clinical settings. BACKGROUND: Hematopoietic stem cells (HSCs), present in blood and bone marrow, can form mature...

Published: 10/3/2024 | Inventor(s): Hanna Mikkola, Julia Aguade Gorgorio

Keywords(s): bone marrow, bone marrow transplants, CRISPR, endocytosis, engraftment, environmental sensing, hematopoietic stem cells, leukemia, MLLT3, MYCT1, transplantability

Category(s): Therapeutics > Hematology, Life Science Research Tools, Therapeutics > Stem Cells And Regenerative Medicine

A Novel “Host-Guest”-Based Supramolecular Hydrogel for Dental Pulp Regeneration (Case No. 2023-154)

Summary: Researchers in the Department of Dentistry at UCLA have developed an innovative hydrogel for a vast array of biomedical and tissue engineering applications. Background: Hydrogels have emerged as powerful tools in biomedical engineering due to their ability to provide a supportive environment for cell growth, tissue repair, and drug delivery....

Published: 10/14/2024 | Inventor(s): Alireza Moshaverinia, Weihao Yuan

Keywords(s): anti-dehydration, Drug Delivery, dynamic identification, hydrogel, Stem Cells / Regenerative Medicine, Targeted Therapy, tissue regeneration

Category(s): Chemical, Materials > Functional Materials, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Cell Therapy, Therapeutics > Medication, Therapeutics > Stem Cells And Regenerative Medicine

Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)

Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...

Published: 7/11/2024 | Inventor(s): Michael Jung, Frank Pajonk

Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine

Method for Combined Conditioning and Chemoselection in a Single Cycle (UCLA Case No. 2011-478)

SUMMARY: Researchers at UCLA have developed a highly-efficient technique to engraft and select hematopoietic stem cells directly inside a patient. The invention will improve the fidelity of stem cell transplantations and reduce toxic side effects on patients. BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a mainstay of treatment for...

Published: 11/15/2024 | Inventor(s): Gay Crooks, Robert Schiestl, Katrin Hacke, Akos Szakmary

Keywords(s): blood cancers, Cancer stem cells, Hematopoietic stem cell transplantation, hematopoietic stem cells, lymphatic cancer, stem cell transplantations, Transplant

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Transplant

2021-182: COMBINING AUTOLOGOUS OR ALLOGENEIC TOTAL MONOCYTES OR CD16+ MONOCYTES TO PROTECT AND INCREASE THE EXPANSION AND FUNCTION OF STEM CELLS.

SUMMARY: UCLA researchers in the department of Dentistry have developed a novel approach to increase the successful transplantation and survival of stem cells into patients. BACKGROUND: The World Health Organization has recognized that transplantation of human cells saves and restores essential life functions to patients who are not presented with...

Published: 11/15/2024 | Inventor(s): Anahid Jewett

Keywords(s):

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2019-870 GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM CELLS (XHIM)

Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells. BACKGROUND:Hematopoietic stem cells (HSCs)—stem cells that give rise to...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s): Gene Editing Systems, Gene Therapy, Genetic Disease, Hematology, Immunotherapy, iPS/stem cells, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2020-443 A PATCH OF DETACHABLE HYBRID MICRONEEDLE DEPOT (D-HMND) FOR LOCALIZED DELIVERY OF MESENCHYMAL STEM CELLS IN REGENERATION THERAPY

UCLA researchers in the Department of Bioengineering have developed a novel detachable hybrid microneedle depot (d-HMND) for the targeted delivery of mesenchymal stem cells. BACKGROUND: Stem cell biology has been widely applied to the treatment of tissue damage, due to the ability of stem cells to form, repair, and maintain tissues and organs after...

Published: 7/19/2023 | Inventor(s): Ali Khademhosseini

Keywords(s): iPS/stem cells, Life Science Research Tools, Stem Cells / Regenerative Medicine, Therapeutics & Vaccines

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2018-850 IMMUNO MODULATORY MATERIAL FOR BRAIN REPAIR

SUMMARY: UCLA researchers in the department of chemical and biomolecular engineering have developed a novel material of hyaluronic hydrogel scaffold with heparin nanoparticles to promote brain regeneration and recovery after stroke.BACKGROUND: Stroke is the leading cause of disabilities in adults and more than 6 million Americans are living with...

Published: 7/19/2023 | Inventor(s): Tatiana Segura, Stanley Carmichael, Lina Nih

Keywords(s): Cns, Medical Devices and Materials, Therapeutics & Vaccines

Category(s): Materials > Membranes, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine

2018-465 ANTIBODY-FREE PROTOCOL FOR GENERATION OF HIGHLY EXPANDABLE, NON-FIBROADIPOGENIC MESODERMAL PRECURSORS FROMHUMAN PLURIPOTENT STEM CELLS FOR TREATMENT

Antibody-Free Protocol For Generation Of Highly Expandable, Non-Fibroadipogenic Mesodermal Precursors from Human Pluripotent Stem Cells For TreatmentTech ID: 30170 / UC Case 2018-465-0SUMMARYUCLA researchers in the Department of Orthopaedic Surgery have developed a novel method to generate mesodermal precursors from human pluripotent stem cells to treat...

Published: 7/19/2023 | Inventor(s): Ayelet Dar, Bruno Peault, Frank Petrigliano

Keywords(s): Musculoskeletal Disease, Stem Cells / Regenerative Medicine, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Musculoskeletal Disease

2007-347 USE OF PERIPHERAL BLOOD MONONUCLEAR CELLS TO TRIGGER DIFFERENTIATION OF MESENCHYMAL STEM CELLS AND OSTEOBLASTS

Use of Peripheral Blood Mononuclear Cells to Trigger Differentiation of Mesenchymal Stem Cells and OsteoblastsSUMMARYUCLA researchers have found that activated NK cells can lyse cancer stem cells, providing a promising approach to the prevention of disease establishment and progression.BACKGROUNDTaken as a whole, roughly half of patients receiving treatment...

Published: 7/19/2023 | Inventor(s): Anahid Jewett

Keywords(s):

Category(s): Therapeutics, Therapeutics > Stem Cells And Regenerative Medicine

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