Search Results - glioblastoma

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Interferon Activation Score Is a Biomarker for Immunotherapy in Malignant Glioma Patients (UCLA Case No. 2024-043)

UCLA researchers from the Department of Neurosurgery have characterized immune responses in malignant glioma patients receiving immunotherapy to develop a robust biomarker that will allow prediction of clinical outcomes following treatment. BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults. No cures exist and most gliomas...

Published: 10/23/2024 | Inventor(s): Robert Prins

Keywords(s): adjuvant therapy, Biomarker, Chemotherapy, Clinical Trial, dendritic cell vaccination, Glioblastoma, Glioma, immune response, Immunotherapy, interferon, malignant glioma

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology, Therapeutics > CNS and Neurology

Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)

Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...

Published: 7/11/2024 | Inventor(s): Michael Jung, Frank Pajonk

Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine

Human Glioblastoma Model (UCLA Case No. 2023-273/2024-151)

UCLA researchers in the Department of Biological Chemistry have developed a novel method to study glioblastoma using human brain organoids. BACKGROUND: The National Institutes of Health defines glioblastoma as the most malignant and pervasive subtype of glioma, or glial-based cancer, and report that it is the most common primary brain tumor in adults....

Published: 6/18/2024 | Inventor(s): Aparna Bhaduri

Keywords(s): Brain cancer, Brain organoid, Brain Tumor, Cancer, Glioblastoma, Organoids

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Oncology

Synthetic Lethality of IR with ABBV-155 in Glioblastoma (GBM) (UCLA Case No. 2021-232)

UCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that irradiation therapy can be combined with an antibody drug conjugate to form a novel therapeutic strategy to treat and extend survival of glioblastoma patients. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain...

Published: 8/28/2024 | Inventor(s): David Nathanson

Keywords(s): Antibody-Drug Conjugate, Apoptosis, Brain cancer, Cancer, Glioblastoma, irradiation

Category(s): Therapeutics > Oncology

Integrated Molecular and Lipidomic Analysis of Glioma Tumors Identifies Therapeutic Vulnerabilities (UCLA Case No. 2023-210)

UCLA researchers in the Department of Molecular and Medical Pharmacology have uncovered a novel therapeutic target for Glioblastoma leveraging an extensive lipidomic and transcriptomic database. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain Tumor Society predicted that over 14,000 people in the United...

Published: 9/25/2024 | Inventor(s): David Nathanson

Keywords(s): Brain cancer, Brain Tumor, cancer target, cell death, ferroptosis, Glioblastoma, lipidomics

Category(s): Therapeutics > Oncology

Targeting the Intrinsic Apoptotic Machinery in Glioblastoma Multiforme (GBM) (UCLA Case No. 2020-446)

UCLA researchers in the Department of Molecular and Medical Pharmacology identified the mechanisms of apoptotic resistance in glioblastoma multiforme (GBM) and developed a novel therapy to treat GBM. BACKGROUND: Glioblastoma (GBM) is the most aggressive form of brain tumor. Therapeutic options for GBM are limited and suboptimal. Treatment usually...

Published: 2/16/2024 | Inventor(s): David Nathanson

Keywords(s): anti-apoptotic inhibitor, Anti-apoptotic pathway, Apoptosis, Brain Tumor, Glioblastoma, irradiation, p53, temozolomide

Category(s): Therapeutics > Oncology