Search Results - manish+butte

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Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/26/2024 | Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

Cellobiose as an Alternative Fuel for T Cells (UCLA Case No. 2021-057)

SUMMARY: UCLA researchers in the Department of Pediatrics have developed a means of utilizing the a biorthogonal sugar called cellobiose as a carbon source for T cells and other mammalian cells for widespread use including as an improved cell therapy platform. BACKGROUND: Cancerous tumors are well characterized to be highly metabolically active as they...

Published: 4/9/2024 | Inventor(s): Manish Butte, Matthew Miller

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

Immunoactive Microparticles and Uses Thereof (UCLA Case No. 2020-200)

SUMMARY: UCLA Researchers from the division of Immunology in the David Geffen School of Medicine have developed an improved method of stimulating anti-tumor T-cells for use in cancer immunotherapy. BACKGROUND: Cancer immunotherapy, a therapeutic strategy whereby a patient’s own immune system is reequipped to attack cancer cells, promises more...

Published: 4/9/2024 | Inventor(s): Manish Butte, Mohammad Hasani-Sadrabadi, Fatemeh Sadat Majedi, Song Li

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Materials > Nanotechnology

2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS

UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...

Published: 9/5/2023 | Inventor(s): Manish Butte, Fatemeh Sadat Majedi

Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy

2020-192 NANOMANUFACTURING PARTICLES

UCLA researchers in the Department of Bioengineering have developed a treatment to introduce local immunomodulation factors, that overcome the side effects associated with systemic cancer immunology treatments. BACKGROUND: When the body’s immune system encounters foreign pathogens, proteins called antibodies are produced to fight infection. Through...

Published: 7/19/2023 | Inventor(s): Manish Butte, Mahdi Hasani

Keywords(s): Drug Delivery, Nanoparticles

Category(s): Platforms > Drug Delivery > Nanoparticles