Search Results - diagnostic+markers+%3e+immunology

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2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning

SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...

Published: 4/9/2024 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics

2021-260: THE INNATE IMMUNE HEALTH SCORE

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a strategy to quantitatively assess the functionality of macrophages, a key player of the innate immune system, using a paired experimental and computational strategy. BACKGROUND: The immune system is formed by two major inter-related components,...

Published: 9/5/2023 | Inventor(s): Alexander Hoffmann

Keywords(s):

Category(s): Software & Algorithms > Bioinformatics, Diagnostic Markers > Immunology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

2021-108 PRECISION CONTROL OF TACROLIMUS SERUM LEVEL FOR IMMUNOSUPRESSION OF POST ORGAN TRANSPLANT PATIENTS

Researchers from UCLA’s Department of Mechanical and Aerospace Engineering and the Department of Psychology have created a new approach for the precise management of tacrolimus, improving patient outcomes following organ transplants. This method proved successful in a 60 patient clinical trial compared to controls and can be applied to other similar...

Published: 11/13/2023 | Inventor(s): Chih-Ming Ho, Jeffrey Huy Khong, Megan Lee, Ali Zarrinpar, Un Bi (Viki) Kim

Keywords(s): Organ Transplant

Category(s): Diagnostic Markers > Immunology

2021-007 Point of Care Electrochemical Immunosensor for the Detection of COVID-19

SUMMARYUCLA researchers in the Department of Electrical and Computer Engineering have developed a wireless, sensitive, and disposable Point of Care (PoC) electrochemical immunosensor for the detection of COVID-19 antibodies. BACKGROUNDCOVID-19 is detected using two main methods: nucleic acid testing and the serological testing. Point-of-Care (POC) devices...

Published: 7/19/2023 | Inventor(s): Aydin Babakhani

Keywords(s):

Category(s): Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies, Therapeutics > Infectious Diseases > COVID

2021-002 System and Methods for Amplified Detection of Molecules on Microparticles

SUMMARYUCLA researchers in the Department of Bioengineering have developed a system to build immunocomplexes, generate and accumulate amplified signals, and perform the signal readout of a digital ELISA using standard benchtop instruments and techniques.BACKGROUNDDigital ELISA allows for the detection and measurement of protein biomarkers at a single-molecule...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Yilian Wang, Vishwesh Nilesh Shah

Keywords(s):

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Antibodies, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS

UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...

Published: 9/5/2023 | Inventor(s): Manish Butte, Fatemeh Sadat Majedi

Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy

2019-880 ZIKA VIRUS-BASED ONCOLYTIC THERAPY FOR BRAIN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel zika virus-based oncolytic therapy to treat brain cancer.BACKGROUND: Glioma is a type of brain tumor that accounts for 80% of all primary malignant brain tumors. Standard therapy for high-grade glioma requires a combination of surgical resection, radiation...

Published: 9/12/2023 | Inventor(s): Vaithilingaraja Arumugaswami, David Nathanson

Keywords(s): Cns, Drug Delivery, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Oncology, Oncology Immunotherapy, Plasmids / Vectors, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Diagnostic Markers > Immunology, Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy

IRIS: Isoform Peptides from RNA Sequencing for Immunotherapy Targets Screening

UCLA Case No. 2018-916SUMMARYResearchers led by Dr. Xing from the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed a big data approach to identify targets for personalized cancer immunotherapy. BACKGROUNDImmunotherapies aim to use the patient’s own immune system to fight cancerous cells, but to be...

Published: 7/19/2023 | Inventor(s): Yi Xing, Yang Pan, Taegyun Yang, Yuanyuan Wang

Keywords(s):

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Data Analytics

Computational Cytometer Based on Magnetically-Modulated Coherent Imaging and Deep Learning

UC Case No. 2019-950 SUMMARY: UCLA researchers in the Department of Electrical & Computer Engineering have designed and built a computational cytometer capable of detecting rare cells at low concentration in whole blood samples. This technique and instrumentation can be used for cancer metastasis detection, immune response characterization and...

Published: 2/16/2024 | Inventor(s): Aydogan Ozcan, Aniruddha Ray, Yibo Zhang, Dino Di Carlo

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Immunology, Life Science Research Tools, Oncology, Software

Category(s): Life Science Research Tools > Lab Equipment, Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Programs

Identification of a Factor that Promotes Human HSC Self-Renewal

Case 2016-990The Mikkola group at UCLA has discovered a novel regulator of hematopoietic stem cell self-renewal. The overexpression of this regulator increases the yield of ex vivo stem cell expansion and could thereby improve the efficiency of stem cell therapies. BACKGROUNDBlood cells are responsible for the maintenance and immune protection of nearly...

Published: 7/19/2023 | Inventor(s): Hanna Mikkola, Vincenzo Calvanese, Andrew Nguyen

Keywords(s): Diagnostic Markers & Platforms, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Life Science Research Tools, Oncology, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Immunology, Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing

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