Search Results - cardiovascular+disease

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Method and Apparatus for Segmentation of Dense MR Images Using Deep Learning with Domain Adaptation (Case No. 2025-208)

Summary: UCLA researchers from the Department of Radiological Sciences have developed a deep learning-based segmentation framework that enables fully automated and reproducible analysis of left ventricular (LV) function in Displacement Encoding with Stimulated Echoes (DENSE) MRI. Background: Myocardial strain is a key metric for analyzing how much...

Published: 8/18/2025 | Inventor(s): Xiaodong Zhong, Siyue Li, Kim-Lien Nguyen

Keywords(s): acute myocardial infarction, adjustable mount, aneurysm drainage, automatic leveling, bedside decisions, blood pressure monitoring, cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, Cardiac MRI, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular monitoring, cerebrospinal fluid (CSF) drainage, Cine MRI, clamp, critical-care, CSF drainage, Deep learning MRI, DENSE MRI, laser alignment, Left ventricular segmentation, lumbar drains, Motion analysis, MRI, multiparametric MRI (mpMRI), Myocardial strain, non-invasive cardiac monitoring, operator variability, passive reflective target, phlebostatic axis measurement, Pseudo-labeling, radial MRI, Segment Anything Model (SAM), self-leveling system, transducer alignment, Unsupervised domain adaptation (UDA)

Category(s): Medical Devices > Cardiac, Electrical > Imaging, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging

Synchronized Biventricular Heart Pacing Using Wirelessly Powered Leadless Pacemakers (Cases 2019-237 & 2020-401)

Summary: UCLA researchers in the department of electrical and computer engineering have developed a device for synchronized biventricular pacing. Background: Many patients with impaired cardiac function suffer from ventricular desynchrony, a condition that involves a lack of synchronization between the contractions of the left and right ventricles...

Published: 7/17/2025 | Inventor(s): Aydin Babakhani, Hongming Lyu, Medhi Razavi, Mathews John, Allison Post

Keywords(s): acute myocardial infarction, cardiac cycle, Cardiac failure, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular modeling, cardiovascular monitoring, cardiovascular prediction, cardiovascular therapeutic solution, medical device cardiac monitoring, non-invasive cardiac monitoring, tachycardia

Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems

Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)

UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...

Published: 7/17/2025 | Inventor(s): Varghese John

Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular

Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)

Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo

Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays

Detection of Dicrotic Notch in Arterial Pressure and Photoplethysmography Signals Using Iterative Envelope Mean Filter (Case No. 2024-034)

Summary: UCLA Researchers in the Department of Anesthesiology have developed an iterative envelope mean (IEM) method for the detection of specific features in arterial pressure monitoring applications. Background: The cardiac cycle consists of the distinct systolic and diastolic phases. The transition from the contracted, systolic phase to the...

Published: 3/26/2025 | Inventor(s): Maxime Cannesson, Ravi Pal, Akos Rudas, Jeffrey Chiang, Sungsoo Kim

Keywords(s): arrhythmia, arterial blood pressure (ABP), cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, diastolic, diastolic phase peak, dicrotic notch, feature extraction tool, iterative envelope method (IEM), Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, non-invasive cardiac monitoring, photoplethysmography (PPG), Smart medical device, systolic, tachycardia, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Software & Algorithms, Diagnostic Markers > Targets And Assays, Diagnostic Markers

Method for Determining the Time Constant for Oxygen Uptake Kinetics (UCLA Case No. 2022-253)

Summary: UCLA researchers in the Department of Medicine have developed a novel geometric model for the determination of the time constant in variable oxygen uptake kinetic systems. Background: The kinetic response of oxygen uptake adjustment to moderate-intensity exercise is a main factor of the aerobic function. Aerobic function is an indicator...

Published: 2/14/2025 | Inventor(s): Christopher Cooper

Keywords(s): breath-by-breath variability, Cardiovascular Disease, cardiovascular modeling, Exercise, exercise physiology, geometric method, kinetics, metabolic measurement, Oxygen, Oxygen kinetics, Oxygen Saturation, Oxygen uptake kinetics, single exercise protocol, time constant

Category(s): Medical Devices > Monitoring And Recording Systems, Software & Algorithms > Digital Health

A Self-Powered Bioelectronic Stent Sensor for Postoperative Blood Flow Rate Monitoring (UCLA Case No. 2022-276)

Summary: UCLA researchers in the Department of Bioengineering have developed a miniaturized bioelectronic stent sensor that provides continuous, real-time, and reliable hemodynamic monitoring. Background: Diseases caused by arterial atherosclerosis are the leading cause of death and disability in the United States, affecting over 4.6 million...

Published: 7/17/2025 | Inventor(s): Jun Chen, Geoffrey Colby, Guorui Chen

Keywords(s): Atherosclerosis, Biomaterial 3D Printing, Biomedical Engineering, Cardiovascular, Cardiovascular Disease, Heart Rate , Medical Device, Medical Devices and Materials, Medical Physics , Nanotechnology, Sensors, Smart medical device, Stent, wearable medical device

Category(s): Mechanical, Materials, Materials > Functional Materials, Materials > Nanotechnology, Medical Devices, Electrical > Mems

2022-267 Enhanced Interpretation of Cardiopulmonary Exercise Test Data

Summary: UCLA researchers in the Department of Medicine have developed a novel software that is capable of analyzing and interpreting standardized cardiopulmonary exercise data and facilitating pattern recognition and data visualization, providing users key insights from raw data. Background: A wide array of exercises exist to evaluate cardiopulmonary...

Published: 2/14/2025 | Inventor(s): Christopher Cooper, Apurva Shah

Keywords(s): Big Data, Cardiovascular, Cardiovascular Disease, Medical Device, Respiratory & Pulmonary, Software, Virtual Reality Occupational Therapy Exercise Machine

Category(s): Software & Algorithms, Software & Algorithms > Digital Health, Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics > Cardiovascular, Software & Algorithms > Data Analytics

2021-275-A TEXTILE MAGNETOELASTIC GENERATOR

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a textile magnetoelastic generator (MEG) that can be used for biomechanical-to-electrical energy conversion. BACKGROUND: The magnetoelastic effect has traditionally been found in rigid metal alloys, but recent research has identified the effect in more flexible materials....

Published: 2/14/2025 | Inventor(s):

Keywords(s): Biosensor, Cardiovascular Disease, Electrical Engineering, Glucose, Magnetoresistive , Materials, Nanomaterials

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Electrical > Sensors