Search Results - life+science+research+tools+%3e+microfluidics+and+mems

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Synthetic Exosomes (SE) for CNS Delivery of CRISPR for Gene Editing in Brain Disorders (UCLA Case No. 2021-363)

UCLA researchers from the Department of Neurology have developed synthetic exosomes, a novel delivery technology capable of transporting gene-editing tools and therapeutics across the blood-brain barrier, with successful applications in repairing Alzheimer’s-related mutations and delivering proteins, antibodies, and drugs. BACKGROUND: The emergence...

Published: 2/18/2025 | Inventor(s): Varghese John

Keywords(s): Alzheimers disease, CRISPR, delivery system, exosome, Nanotechnology, nanovesicles, synthetic biology

Category(s): Life Science Research Tools > Microfluidics And Mems, Materials > Nanotechnology, Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Therapeutics > CNS and Neurology

A Fabrication Method for High-Precision, Large-Area Acoustic Single-Cell Trapping Devices (Case No. 2025-115)

Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel fabrication method for single-cell trapping devices. Background: Single-cell analysis is critical to personalized medicine, diagnostics, and biomedical research, as it allows researchers to identify, isolate, and expand desired cell subpopulations....

Published: 3/20/2025 | Inventor(s): Pei-Yu Chiou, Jacob Smith

Keywords(s): acoustic manipulation, acoustics, air cavity formation, cell sorting, compliant membrane acoustic patterning (CMAP), Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, high-throughput analysis, large-area arrays, MEMS, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared (NIR) pulsed laser, PDMS, PDMS membranes, single cell analysis, Single cell data, single-cell resolution, single-cell trapping

Category(s): Materials, Materials > Membranes, Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Cell Counting And Imaging, Platforms

High-Throughput Cargo Delivery Into Live Cells Using Photothermal Platforms (Case No. 2013-158)

Summary: UCLA researchers in the Department of Mechanical Engineering have developed a photothermal platform for precisely opening a cell membrane to deliver cargo into cells. Title: High-Throughput Cargo Delivery Into Live Cells Using Photothermal Platforms Background: Transferring cargo like proteins, nucleotides and particles into cells is valuable...

Published: 2/14/2025 | Inventor(s): Pei-Yu Chiou, Michael Teitell, Ting Hsiang Wu, Yi-Chien Wu

Keywords(s): cell engineering, cellular, delivery system, Gene delivery, Laser, Microbiology, Micropump

Category(s): Electrical > Mems, Life Science Research Tools > Microfluidics And Mems

Core-Shell Hydrogel Particles With Tunable Porosity for Digital Nucleic Acid Assays (Case No. 2023-058)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel method to perform ultra-high sensitivity, low-cost nucleic acid amplification assays utilizing porous microdroplets. Background: Nucleic acid concentration measurement is essential in biological research and diagnostics. The 2020 pandemic underscored the importance...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Michael Bogumil

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Flow Cytometry, Medical diagnostics

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Chemical > Emulsions, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

Robot-On-A-Dish: Automating Cellular Sorting and Analysis via Robotic Motor-Driven Flow (Case No. 2023-002)

Summary: UCLA researchers in the Department of Bioengineering have built a new cell sorting system that can handle and maintain linear flow control for a broad range of mesoscale particles in fluids. Background: The global market for drug discovery technologies was valued at $65.3 billion in 2019, and it is expected to grow at a CAGR of 9.6%....

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Reem Khojah

Keywords(s): Cell Counting/Imaging, Content Analysis, Diagnostic Markers & Platforms, Drug Discovery, Flow Cytometry, Flow Device, High-Throughput Screening, mesoscale, mesoscale particles, Robotic liquid handling

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Chemical, Chemical > Instrumentation & Analysis, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2021-118 RAPID RESPONSE MICROFLUIDIC CHIP FOR SCREENING THROMBOTIC RISK FROM S-SPIKE PROTEIN IN THE CONTEXT OF SARS-COV-2

SUMMARY: UCLA researchers in the Department of Medicine and Bioengineering have developed a novel microfluidic approach to study SARS-CoV-2 infection entry into blood cells of COVID-19 patients as a research tool to better understand the mechanisms that lead to blood clot formation. BACKGROUND: The World Health Organization estimates that there are...

Published: 2/14/2025 | Inventor(s): Tzung Hsiai, Angela Lai, Sandro Satta

Keywords(s):

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2020-908 LASER ACTUATED SUPERCRITICAL INJECTOR (LASI)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering developed a platform that applies high-speed fluidic jet injection of biomolecules into biological samples with the use of laser actuated supercritical injector (LASI). Background: Intracellular delivery of various biomolecules has been of great importance in biomedical...

Published: 2/14/2025 | Inventor(s): Pei-Yu Chiou

Keywords(s):

Category(s): Life Science Research Tools > Microfluidics And Mems, Platforms > Drug Delivery, Optics & Photonics, Materials > Nanotechnology

2020-887 A Programmable Epidermal Microfluidic Valving System for Wearable Biofluid Management and Contextual Biomarker Analysis

SUMMARYResearchers in the UCLA Electrical and Computer Engineering Department have devised a programmable epidermal microfluid valving system for high frequency, real-time biofluid sampling, routing, and compartmentalization in wearable bioanalytical platforms.BACKGROUNDWearable biomarker sensing technologies allow for the frequent, longitudinal, and...

Published: 2/14/2025 | Inventor(s): Sam Emaminejad, Haisong Lin, Jiawei Tan

Keywords(s):

Category(s): Electrical > Electronics & Semiconductors, Electrical > Sensors, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies

2019-879 An Electronically-Controlled Digital Ferrofluidic Architecture for Scalable and Addressable Bioanalytical Operations

SUMMARYUCLA researchers in the Department of Electrical and Computer Engineering have developed a contactless digital ferrofluidic approach for small-volume droplet generation, manipulation and transport. BACKGROUND Automated microfluidic technologies can perform autonomous, accurate, and consistent fluidic operations. Current automated systems have...

Published: 2/14/2025 | Inventor(s): Sam Emaminejad, Dino Di Carlo

Keywords(s):

Category(s): Materials > Nanotechnology, Life Science Research Tools > Microfluidics And Mems, Materials > Fabrication Technologies, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nanoparticles, Chemical > Industrial & Bulk Chemicals

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