Search Results - life+science+research+tools+%3e+research+methods

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Methods for Generating Spatially Resolved Genomic Profiles From Tissues (UCLA Case No. 2022-112)

UCLA researchers in the Department of Human Genetics have developed a scalable, high-precision in situ spatial barcoding method, enabling spatially-resolved single-cell and subcellular genomic profiling, including transcriptomics and epigenomics, with targeted cell selection guided by immunofluorescence. BACKGROUND: Recent advancements in spatial transcriptomics...

Published: 7/17/2025 | Inventor(s): Chongyuan Luo

Keywords(s):

Category(s): Life Science Research Tools > Research Methods

Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)

Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...

Published: 8/19/2025 | Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell

Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics

Targeting the Bile Acid Pathway to Treat Cardiometabolic Disease (UCLA Case No. 2024-146)

UCLA researchers from the Department of Medicine and Division of Cardiology have identified target enzymes involved in bile acid synthesis and developed methods to improve disease outcomes in fatty liver and atherosclerosis. BACKGROUND: Dietary fat is an essential, energy-dense nutrient necessary for survival. To support this, the intestinal system...

Published: 7/17/2025 | Inventor(s): Thomas Vallim

Keywords(s):

Category(s): Life Science Research Tools > Screening Libraries, Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology, Life Science Research Tools > Research Methods, Therapeutics > Cardiovascular

Methods for Building RNA Organelles in Vitro (UCLA Case No. 2023-286)

UCLA researchers from the Department of Bioengineering have developed artificial RNA sequences that can form condensates in vitro, allowing customization of cellular function in membrane-less organelles. BACKGROUND: RNA condensates are intracellular membrane-less compartments formed by phase separation, involving RNA and proteins. These RNA condensates...

Published: 7/17/2025 | Inventor(s): Elisa Franco

Keywords(s): Nanotechnology, RNA, synthetic biology

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Plasmids/Vectors

AI-Powered System for Objective Surgical Skill Assessment in Open Procedures (Case No. 2025-207)

Summary: UCLA researchers in the Department of Surgery have developed a deep-learning architecture to efficiently and accurately assess surgeon skill level for improved medical training. Background: Objectively assessing surgical trainee performance during open procedures remains a significant challenge in medical education. Traditional evaluations...

Published: 8/13/2025 | Inventor(s): Peyman Benharash, Armin Alipour

Keywords(s): AI, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, deep-learning analysis algorithms, Education technology, image-guided surgery, medical bias reduction, Quality Control, Surgery, Surgical Instrument, Surgical Tools, teaching

Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools > Research Methods, Medical Devices > Hospital Systems, Medical Devices > Monitoring And Recording Systems, Medical Devices > Surgical Tools, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Communication & Networking, Software & Algorithms > Digital Health

A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)

Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...

Published: 7/28/2025 | Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen

Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer

Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors

Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)

Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...

Published: 3/3/2025 | Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman

Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy

Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)

Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...

Published: 7/17/2025 | Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment

Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)

UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...

Published: 7/17/2025 | Inventor(s): David Wong

Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)

Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

Cell Type Scanner (UCLA Case No. 2021-115)

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel technology for spatial cell-type mapping in 2D and 3D tissue samples. BACKGROUND: Cell type mapping has become an integral component for many biomedical research studies and diagnostic technologies. However, a major challenge in single cell data is accurately...

Published: 7/17/2025 | Inventor(s): Roy Wollman

Keywords(s): 3D tissue imaging, cell mapping, Principal component analysis, RNA imaging, single cell analysis, Single cell data

Category(s): Life Science Research Tools > Research Methods, Software & Algorithms > Data Analytics

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