Search Results - life+science+research+tools+%3e+research+methods

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Directed Differentiation Protocols to Derive Bone Fide Spinal Sensory Interneurons (UCLA Case No. 2022-224)

UCLA researchers from the Department of Neurobiology have developed innovative protocols to differentiate and expand spinal sensory interneurons for drug discovery and to utilize in cell replacement therapies to restore injured spinal cords. BACKGROUND: Spinal cord injuries (SCIs) can result in the loss of controlled movement and somatosensation, the...

Published: 10/10/2025 | Inventor(s): Samantha Butler

Keywords(s):

Category(s): Life Science Research Tools > Research Methods, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > CNS and Neurology

Interactive Systems and Methods for Identifying Target Proteins in Drug Discovery (Case No. 2025-098)

Summary: UCLA researchers from the Department of Electrical and Computer Engineering have developed a novel computational system for target protein identification, enabling integrative drug discovery. Background: Target identification (Target ID) in drug discovery involves the identification and evaluation of protein candidates that could interact...

Published: 10/1/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang, Ziwen Li, Jesus Campagna, Varghese John, Whitaker Cohn, Eunice Jun

Keywords(s): AI-driven drug discovery, Alzheimer’s disease target discovery, Bioinformatics software platform, Drug, Drug Discovery, Functional annotation of proteins, High-throughput docking, large language models (LLMs), Ligand-protein docking, Mechanism-of-action prediction, Molecular docking simulation, Multi-criteria decision support, Neurodegenerative disease therapeutics, Pathway-centric drug targeting, personalized medicine, PPI-Comparator, PPI-Explorer, Protein structure prediction, Protein-protein interaction (PPI) analysis, Rational drug design, Retrieval-augmented generation (RAG), Semantic similarity modeling, Small molecule screening, Systems biology interface, Target identification (Target ID), Therapeutic impact modeling, User-guided AI exploration

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms, Platforms > Drug Delivery

Pulsed Laser Triggered High Speed Microfluidic Switch and Applications in Flourescent Activated Cell Sorting (Case No. 2009-063)

Summary UCLA researchers have developed a pulsed-laser triggered microfluidic switching mechanism capable of sub-100 µs switching (e.g. ~70 µs), enabling ultrafast cell/particle sorting in a microfluidic fluorescence-activated cell sorting (µFACS) platform using cavitation bubbles rather than mechanical valves. Background Flow cytometry...

Published: 9/25/2025 | Inventor(s): Pei-Yu Chiou, Ting Hsiang Wu

Keywords(s):

Category(s): Optics & Photonics, Optics & Photonics > Lasers, Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods

Pulse Laser Driven High Speed, On-Demand, and Multiplexed Droplet Generator (Case No. 2013-184)

Summary UCLA researchers have developed a high-speed, on-demand microfluidic droplet platform that allows rapid and precise generation, manipulation, and merging of microdroplets for advanced lab-on-a-chip applications. The technology enables controlled droplet initiation and synchronized merging at high throughput, making it a versatile platform for...

Published: 9/24/2025 | Inventor(s): Pei-Yu Chiou, Michael Teitell, Ting Hsiang Wu, Yue Chen, Yu Chun Kung

Keywords(s):

Category(s): Optics & Photonics, Optics & Photonics > Lasers, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging

An Organometallic Chemistry Approach to Peptide Tricycles (UCLA Case No. 2025-99O)

Contact UCLA Technology Development Group to learn more. Preprint: Adhami N, Rebelo M, Jenkins R, Olivares E, Loo R, Qu S, et al. An Organometallic Chemistry Approach to Peptide Tricycles. ChemRxiv. 2025; doi:10.26434/chemrxiv-2025-mkz71

Published: 9/19/2025 | Inventor(s): Alexander Spokoyny

Keywords(s):

Category(s): Life Science Research Tools > Research Methods

Method for Scalable Spatially Resolved Molecular Recording (UCLA Case No. 2025-049)

Contact UCLA Technology Development Group to learn more. Keywords: spatially resolved omics technologies, transcriptomics, genomics, spatial molecular recording

Published: 9/17/2025 | Inventor(s): Amjad Askary

Keywords(s):

Category(s): Life Science Research Tools > Research Methods

Cohesive CLEM, TEM, FEBSEM System for MicroED and Cryo-EM Applications (Case No. 2025-010)

Summary UCLA researchers have developed a cohesive electron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...

Published: 9/12/2025 | Inventor(s): Tamir Gonen, Michael Martynowycz

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods, Medical Devices, Medical Devices > Medical Imaging, Platforms

Discrete Approximation of Permanent Magnet Arrays (Case No. 2025-203)

Summary UCLA researchers have developed Discrete-MAG, a discrete magnetic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...

Published: 10/8/2025 | Inventor(s): Tyler Clites, He Kai Lim, Will Flanagan, Cameron Taylor

Keywords(s):

Category(s): Materials, Materials > Functional Materials, Medical Devices, Mechanical, Mechanical > Robotics, Platforms, Platforms > Drug Delivery, Medical Devices > Medical Imaging, Life Science Research Tools, Life Science Research Tools > Research Methods

Methods for Automation and Compositional Analyses of MicroED Data (Case No. 2023-256)

Summary UCLA researchers have developed an automated Microcrystal Electron Diffraction (MicroED) microscopy system and method that autonomously identifies, images, and analyzes micro-crystals on an EM grid. The system captures low-magnification atlases, selects promising grid squares, acquires higher-magnification montages, sets focus, captures continuous-rotation...

Published: 9/11/2025 | Inventor(s): Tamir Gonen, Johan Unge

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods

Synthetic Notch Receptors for Use in Customized Spatial Control of Multiple Gene Expressions and Uses Thereof (UCLA Case No. 2023-261)

Researchers at UCLA and USC have developed a modular invention that enables customized spatial control of multiple gene expressions in living cells using synthetic Notch (synNotch) receptors, with broad applications in tissue engineering, synthetic morphogenesis, and regenerative medicine. BACKGROUND: Precise spatial control of gene expression is fundamental...

Published: 9/11/2025 | Inventor(s): Song Li

Keywords(s):

Category(s): Platforms, Life Science Research Tools > Research Methods

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