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Brain Repair in Vascular Dementia and Stroke with A3AR (UCLA Case No. 2024-220)

UCLA researchers from the Department of Neurology have discovered and validated intercellular signaling pathways that can be therapeutically targeted to drive repair and functional recovery in vascular dementia. BACKGROUND: Vascular dementia (VaD) is the second leading cause of dementia and is driven by ischemic injury to cerebral white matter, producing...

Published: 10/14/2025 | Inventor(s): Stanley Carmichael

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular, Life Science Research Tools > Animal Models

Directed Differentiation Protocols to Derive Bone Fide Spinal Sensory Interneurons (UCLA Case No. 2022-224)

UCLA researchers from the Department of Neurobiology have developed innovative protocols to differentiate and expand spinal sensory interneurons for drug discovery and to utilize in cell replacement therapies to restore injured spinal cords. BACKGROUND: Spinal cord injuries (SCIs) can result in the loss of controlled movement and somatosensation, the...

Published: 10/10/2025 | Inventor(s): Samantha Butler

Keywords(s):

Category(s): Life Science Research Tools > Research Methods, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > CNS and Neurology

Syndrome Sphere Decoding of Linearly Expurgated Tail-Biting Convolutional Codes (Case No. 2025-285)

Summary: UCLA researchers have developed Syndrome Sphere Decoding (SSD), a breakthrough algorithm that delivers near-optimal error correction for tail-biting convolutional codes (TBCCs) with dramatically reduced decoding complexity. By eliminating the need for large list decoders, SSD enables faster, low-power, and reliable communication across wireless,...

Published: 10/10/2025 | Inventor(s): Richard Wesel, Wenhui Sui, Bruce Qu

Keywords(s): Convolutional codes, design software, Low-Density Parity-Check Code, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, tail-biting convolutional codes

Category(s): Electrical, Electrical > Signal Processing, Electrical > Wireless, Software & Algorithms > Communication & Networking, Software & Algorithms > Security & Privacy

Miniaturized Batteryless and Wireless Biopotential Recorder with Dynamic Bandwidth and Data Rate Update for Power Optimization (Case No. 2026-015)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a miniaturized, batteryless biopotential recorder with adaptive bandwidth, low power consumption, and synchronized data acquisition for next-generation implantable medical devices. Background: Biopotential signals—including electrocardiograms,...

Published: 10/9/2025 | Inventor(s): Aydin Babakhani, Roshan Mathews

Keywords(s): Bandwidth (Signal Processing), Bandwidth (Signal Processing) RF Transmitters, Clock Signal, Computer-Aided Diagnosis, Data Acquisition, Data Recovery, Electrical, Electrical Engineering, high-data-rate links, Integrated Circuit, low-power architecture, low-power device, Mixed-Signal Integrated Circuit, Monitoring And Recording Systems, Printed Circuit Board, Signal Processing, System On A Chip, Wireless, wireless communication, wireless connectivity

Category(s): Electrical, Electrical > Signal Processing, Electrical > Wireless, Electrical > Electronics & Semiconductors > Circuits, Medical Devices > Monitoring And Recording Systems, Medical Devices

Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)

Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...

Published: 10/9/2025 | Inventor(s): Andrew Leuchter, Juliana Corlier, Thomas Valles

Keywords(s): Bioelectromagnetics, Brain, Deep Brain Stimulation, Electrical Brain Stimulation, energy-efficient, frequency modulation, Magnetic Field, Medical Device, medication efficacy, neural information, neural network, neural networks, neural signals, neural stimulation, neurobehavioral impairment, Neurocognitive, neurological disorders, Neuromodulation, Neuron, neurons, neuroscience, Neurostimulation, pulsed load modulation, therapy, treatment efficacy

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Life Science Research Tools, Therapeutics > CNS and Neurology, Therapeutics

Combination Metabolic-Epigenetic Treatment for Early Lung Cancer (UCLA Case No. 2022-247)

UCLA researchers in the Division of Pulmonary Medicine at the School of Medicine uncovered a novel mechanism by which cancer cells adapt to glucose restriction and develop treatment resistance, and have in response developed a novel combination therapy to delay lung adenocarcinoma development while circumventing the development of aggressive behavior...

Published: 10/8/2025 | Inventor(s): Claudio Scafoglio

Keywords(s):

Category(s): Therapeutics > Respiratory And Pulmonary, Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

Doping of Thorium-229 Into High Bandgap Metal Sulfate Material (Case No. 2025-99Y)

Summary: A UCLA researcher in the Department of Physics has developed a novel method for creating high-bandgap materials doped with thorium-229, enabling the development of advanced nuclear clocks. Background: Thorium-229 is the only known isotope with a nuclear transition low enough to be measured using conventional optical techniques. The combination...

Published: 10/9/2025 | Inventor(s): Eric Hudson

Keywords(s): Clock Signal, high-powered laser systems, Laser, laser alignment, Laser Diode, lasers

Category(s): Materials, Materials > Functional Materials, Optics & Photonics, Optics & Photonics > Lasers, Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Electrical > Sensors, Electrical > Instrumentation, Electrical > Quantum Computing, Energy & Environment, Energy & Environment > Thermal, Materials > Nanotechnology, Materials > Fabrication Technologies, Materials > Semiconducting Materials

Method and Apparatus for Acceleration of Dense MR Data Acquisition (Case No. 2025-226)

Summary: UCLA researchers from the Department of Radiological Sciences have developed a novel acquisition and reconstruction strategy that accelerates Displacement Encoding with Stimulated Echoes (DENSE) MRI, enabling faster and clinically feasible cardiac strain measurement. Background: Myocardial strain is an important biomarker for assessing how...

Published: 10/8/2025 | Inventor(s): Xiaodong Zhong, Shu-Fu Shih

Keywords(s):

Category(s): Electrical > Imaging, Electrical > Signal Processing, Medical Devices > Cardiac, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Platforms > Diagnostic Platform Technologies, Software & Algorithms > Data Analytics, Software & Algorithms, Software & Algorithms > Image Processing

Compliant Mechanisms That Perform Mathematical Operations via Analog Computing (Case No. 2025-230)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a fully compliant mechanism that performs mathematical operations using analog computing. Background: Mechanical computers rely on the relative motion of physical bodies to perform computations, rather than electronic signals, as electrical computers...

Published: 10/7/2025 | Inventor(s): Jonathan Hopkins, Pietro Sainaghi, Alexander Tsao, Zhidi Yang

Keywords(s): Advanced Computing / AI, Aerospace, Aerospace Engineering, analog computing, analog optical computing, computational efficiency, feature space, low latency computing, space compatible inks, Space Shuttle, Spacecraft

Category(s): Mechanical, Mechanical > Aeronautics & Aerospace, Mechanical > Instrumentation, Mechanical > Mechanical Systems, Mechanical > Micro-Electromechanical Systems (Mems), Mechanical > Sensors, Materials, Materials > Functional Materials

Combination of Insulin-like Growth Factor-1 Receptor (IGF1R) or Insulin Receptor Inhibitors with Immune Checkpoint Inhibitors in Management of Triple-Negative Breast Cancer (UCLA Case No. 2020-872)

UCLA researchers in the Department Joe C. Wen School of Nursing have developed a novel targeted therapy for triple-negative breast cancer with a potential synergy with immunotherapy. BACKGROUND: Triple-negative breast cancer (TNBC) accounts for about 10-15% of women with breast cancer (BC), but its mortality rate is disproportionally high, causing...

Published: 10/6/2025 | Inventor(s): Nalo Hamilton

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Metabolism And Endocrinology, Diagnostic Markers > Cancer

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