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Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)

UCLA researchers in Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...

Published: 2/5/2026 | Inventor(s): Aldons Lusis, Yang Cao

Keywords(s):

Category(s): Therapeutics > Cardiovascular

Coagulation Factor XI (FXI) Functional Roles and Regulation for Treatment of Heart Failure (UCLA Case No. 2022-141)

UCLA researchers from the Department of Medicine have discovered a novel therapeutic target (between the interaction of the heart and liver) to treat heart failure with preserved ejection fraction (HFpEF), which afflicts approximately half of all patients with heart failure. Contact UCLA Technology Development Group for more information. Related papers...

Published: 2/5/2026 | Inventor(s): Aldons Lusis

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

Microfluidic Lab-on-Chip Device, Small Molecules and Three-Dimensional Spheroids for Cell Reprogramming (UCLA Case No. 2020-881)

UCLA researchers in the Department of Bioengineering at David Geffen School of Medicine developed a microfluidic device that can significantly promote cell reprogramming and direct induced neuronal reprogramming with high specificity. This invention is important for basic science, disease modeling, therapeutic testing, functionalizing knowledge for...

Published: 2/5/2026 | Inventor(s): Song Li, Yang Song

Keywords(s):

Category(s): Life Science Research Tools > Microfluidics And Mems

Highly Miniaturized Closed-Loop Biosensing and Drug Delivery (Case No. 2025-276)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an implantable closed-loop system that integrates electrochemical biosensing, wireless signal transmission, and programmable drug release. Background: Conventional disease management systems rely on single-point measurements and discrete interval drug...

Published: 2/5/2026 | Inventor(s): Aydin Babakhani, Iman Habibagahi, Hamid Jafarisharemi, Roshan Mathews

Keywords(s): biomedical implantation, biomedical sensors, Drug Delivery, Drug monitoring, Implant (Medicine), implantable sensors, Medical Device, minimally invasive drug delivery systems, on-demand drug delivery, personalized dose assessment, Smart medical device, Therapeutics, wearable, wearable electronics, wearable medical device, wearable medical devices, wearable sensors, wearable sensors for health, Wireless, wireless communication

Category(s): Life Science Research Tools, Electrical, Medical Devices, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery, Platforms

A Wearable Magnetoelastic Patch for Cervical Spines Care (Case No. 2026-076)

Summary: UCLA researchers have developed a soft, wearable magnetoelastic patch designed for real-time, non-invasive monitoring of cervical spine pressure and motion, enabling early detection and personalized care for infants with potential neck or spine disorders. Background: Infant cervical spine injuries present a significant diagnostic challenge...

Published: 2/4/2026 | Inventor(s): Jun Chen

Keywords(s): Neurosurgery/Spine

Category(s): Diagnostic Markers > Pediatrics, Electrical > Electronics & Semiconductors, Electrical > Flexible Electronics, Electrical > Sensors, Materials > Fabrication Technologies, Mechanical > Sensors, Medical Devices > Monitoring And Recording Systems, Software & Algorithms > AI Algorithms, Therapeutics

Lesion Estimation with Geometric Object Measurement (LE-GEOM) (Case No. 2025-077)

Summary: UCLA researchers in the Department of Radiology have developed a novel, automated approach for tumor assessment by determining RANO-compliant tumor diameters from tumor segmentation data. Background: MRI tumor measurements are critical in both clinical trials and clinical practice. Traditionally, radiologists manually assessed tumors by...

Published: 1/29/2026 | Inventor(s): Benjamin Ellingson, Francesco Sanvito, Catalina Raymond

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Medical Devices, Medical Devices > Medical Imaging, Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Bioinformatics

Misalignment Resilient Diffractive Optical Networks (Case No. 2020-885)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed and experimentally validated a comprehensive training scheme that greatly enhances the robustness of diffractive networks to 3D misalignments and fabrication tolerances in their physical implementation. Background: As an optical machine learning framework,...

Published: 1/28/2026 | Inventor(s): Aydogan Ozcan

Keywords(s): Optical Communication , Optical computing, optical implementation, Optical networks, optical processor

Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Optics & Photonics

Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)

UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.

Published: 1/27/2026 | Inventor(s): Gay Crooks, Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases

Enhancing T Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)

UCLA researchers from the Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. Contact UCLA Technology Development Group for more information.

Published: 1/27/2026 | Inventor(s): Gay Crooks, Christopher Seet

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

A Selenium Buffer Method for Making Van Der Waals Contact on CDTE Wafers With High Surface Roughness (Case No. 2025-173)

Summary: UCLA researchers in the Department of Chemistry & Biochemistry have developed a novel method for implementation of Van der Waals contact on commercial CdTe wafers for improved photovoltaic and solar panel production. Background: Cadmium Telluride (CdTe) is a common absorber used for thin-film optoelectronics and photovoltaics, including...

Published: 1/28/2026 | Inventor(s): Yu Huang, Xiangfeng Duan, Bangyao Hu

Keywords(s):

Category(s): Electrical, Electrical > Electronics & Semiconductors, Electrical > Electronics & Semiconductors > Waferscale Computing, Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Electrical > Sensors, Energy & Environment, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Generation, Materials, Materials > Semiconducting Materials

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