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Analoging and SAR-Based Chemical Approach to Improve the Therapeutic Potency of Small-Molecule Inhibitors of Metastasis (UCLA Case No. 2024-116)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed an analoging and SAR-based chemical approach to generate novel, safe, and effective small-molecule inhibitors for preventing and treating cancer metastasis. BACKGROUND: The limited understanding of the biological mechanisms underlying metastasis in clear cell renal...

Published: 5/14/2025 | Inventor(s): Lily Wu, Moe Ishihara, Robert Damoiseaux, Stuart Conway

Keywords(s): Cancer, Metastasis, Oncology (Small Molecules, Peptides and Antibodies), Small molecule therapeutics, small molecules

Category(s): Therapeutics > Oncology

Mechanical Neural Network Driven by Flexure-Based, Meso-Scale, Bidirectional Thermal Actuators (Case No. 2024-235)

Summary: UCLA researchers in the Department of Mechanical Engineering have developed a novel bidirectional thermal linear transducer for active vibration dampening and high precision manufacturing equipment. Background: Metamaterials are engineered structures that demonstrate properties not commonly found in natural materials. To date, most...

Published: 5/14/2025 | Inventor(s): Jonathan Hopkins, Pietro Sainaghi, Michael Cullinan, Andrew Gray

Keywords(s):

Category(s): Materials, Materials > Functional Materials, Materials > Fabrication Technologies, Materials > Construction Materials, Materials > Composite Materials, Mechanical, Mechanical > Aeronautics & Aerospace, Mechanical > Sensors, Mechanical > Micro-Electromechanical Systems (Mems), Mechanical > Mechanical Systems

Batch Processing for Imaris Stitcher (Case No. 2025-089)

Summary: Researchers in UCLA’s Department of Neurobiology have developed a novel software tool that enhances the capabilities of Imaris Stitcher. The tool enables batch processing and automated execution of multiple image stitching jobs, significantly improving workflow efficiency and reducing hands-on time. This results in readily available,...

Published: 5/13/2025 | Inventor(s): Ian Bowman, Mitchell Rudd, Hong Wei Dong

Keywords(s): 3D tissue imaging, 3D ultrasound imaging, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, artificial-intelligent materials, bioimaging, Cell Counting/Imaging, cell imaging, cell mapping, computational imaging, Data Acquisition, Data Aggregator, Data Analytics, Data Recovery, Data Structure, Fluorescence Microscope, histopathology images, Image Analysis, image restoration, image signal processing, Imaging, Magnetic Resonance Imaging, Medical artificial intelligence (AI), Medical Imaging, Microscope, Microscopy, Microscopy And Imaging, Molecular Imaging, multi-contrast imaging, Neuroimaging, non-invasive imaging, pathology image analysis, Phase-Contrast Imaging, three dimensional imaging, volumetric image

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing

Methods of Electrode Configurations and Montages to Achieve Spatial Selectivity of Nerve Stimulation (Case No. 2024-277)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel method for spatially selective electrical nerve stimulation. Background: Peripheral nerve stimulation (PNS) is a common form of treatment for various ailments, such as chronic pain. This approach offers a non-pharmacological and minimally invasive option....

Published: 5/13/2025 | Inventor(s): Jonathan Brand, Wentai Liu

Keywords(s): Consumer Electronics, Digital Electronics, Electrode, Electrode 3D Printing, electrodes, Electroencephalography (EEG), Flexible Electronics, Machine Learning Pain Management, Neuropsychological Test, Optoelectronics, Organic Electronics, Pain Treatment, Paint, Printed Electronics, Psychiatry / Mental Health, Psychology, Psychotherapy, soft electronics, Stretchable electrodes, tissue-electronic interface, wearable electronics

Category(s): Electrical, Electrical > Instrumentation, Electrical > Flexible Electronics, Medical Devices, Medical Devices > Neural Stimulation, Therapeutics, Therapeutics > Psychiatry And Mental Health

Methods for Building RNA Organelles in Vitro (UCLA Case No. 2023-286)

UCLA researchers from the Department of Bioengineering have developed artificial RNA sequences that can form condensates in vitro, allowing customization of cellular function in membrane-less organelles. BACKGROUND: RNA condensates are intracellular membrane-less compartments formed by phase separation, involving RNA and proteins. These RNA condensates...

Published: 5/12/2025 | Inventor(s): Elisa Franco

Keywords(s): Nanotechnology, RNA, synthetic biology

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Plasmids/Vectors

Encapsulation of Fire-Resistant Materials in Adhesive Polymeric Carriers for Fire Prevention (Case No. 2025-240)

Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel system for integrating fire-retardant compounds within an adhesive and sprayable material. Background: Fire management traditionally relies on the use of synthetic materials containing ammonium polyphosphate (APP), which are effective in fire suppression...

Published: 5/12/2025 | Inventor(s): Paul Weiss, Erika Lopez Lara

Keywords(s): antimicrobial materials, Composite Materials, Construction Materials, fire, fire resistant materials, fire resistant materials and nanotechnology, fire retardant, fire tech nanomaterials, Functional Materials, intercalated materials, Materials, Medical Devices and Materials, meta materials, microarchitectured materials, Nanomaterials, nanostructured materials, palisades, phase change materials, photothermal materials, safe materials, wildfire, wildfire prevention

Category(s): Materials, Materials > Fabrication Technologies, Materials > Functional Materials, Energy & Environment

Efficient One-Step Chemical Conversion of MXene Into Quantum Dots (Case No. 2025-246)

Summary: UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel one-step method for producing MXene quantum dots with precise size control in an environmentally safe manner. Background: Quantum dots are widely used in bioimaging due to their tunable optical, electrical, and chemical properties. However, traditional...

Published: 5/6/2025 | Inventor(s): Paul Weiss, Haiyue Huang, Judy Cheng

Keywords(s): Biochemistry, bioimaging, Biomaterial, Catalysts, Chemical, Chemical Manufacturing & Industrial/Bulk Chemicals, energy conversion, energy conversion applications, Functional Materials, labeling, material science, Materials, Nanomaterials, photoluminescence, Quantum Dot

Category(s): Chemical, Chemical > Synthesis, Materials, Materials > Semiconducting Materials

Emissions-Free Olefin Synthesis via Concentrated Solar-Thermal Pyrolysis for Cleaner Plastics (Case No. 2025-008)

Summary: UCLA researchers in the department of mechanical and aerospace engineering have developed a novel technology that utilizes concentrated solar radiation to convert petroleum refinery hydrocarbons into light olefins with no CO2 emissions and generates a high-value graphitic carbon co-product. Title: Emissions-Free Olefin Synthesis via Concentrated...

Published: 5/6/2025 | Inventor(s): Anil Nair, Raymond Spearrin, Barathan Jeevaretanam

Keywords(s): bulk material, clean material production, Composite Material, Composite Materials, Concentrated Solar Power, Concentrated Solar Power Chemical Engineering, concentrated solar radiation, Construction Materials, emission free materials, ethylene, fire resistant materials, Functional Materials, graphitic carbon, HDPE, high density polyethylene, intercalated materials, LDPE, light olefin, low density polyethylene, material characterization, Material for Enhanced Photoprotection, material science, Materials, Medical Devices and Materials, Nanomaterials, olefin, olefin synthesis, plastic, plastic fabrication, plastic production, plastics, polypropylene, propylene, pyrolysis, Raw materials supplier, safe materials, Smart Material, zero emissions

Category(s): Materials, Materials > Functional Materials, Materials > Fabrication Technologies, Energy & Environment

Apparatus and Method for Low-Power EMG and EEG Devices for HMI (Case No. 2023-146)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed compact, low-power neural signal sensing solutions to enhance human-machine interfaces (HMI), including AR/VR systems. Background: Electrogram technologies, such as electroencephalogram (EEG) and electromyography (EMG), are widely used to capture biological...

Published: 5/14/2025 | Inventor(s): Aydin Babakhani, Sepideh Nouri

Keywords(s): Antennas/Wireless, Augmented Reality, Biosensor, Brain computer interface, brain machine interface, Electroencephalography, Electroencephalography (EEG), energy-efficient wireless communication, Extended reality, Human/Brain computer interfaces (BCI/HCI), Microelectronics, motion detection, on-eyelid sensor, Radar / Antennae, real-time sensing/monitoring/tracking, Remote Sensing, self-powered wireless sensor solutions, smart sensing, Software & Algorithms, Virtual Reality, wearable electronics, wearable sensors

Category(s): Electrical > Sensors, Electrical > Electronics & Semiconductors, Electrical, Software & Algorithms, Software & Algorithms > Ar/Vr

Charge Storage Device Architecture for Increased Energy and Power Density (Case No. 2009-392)

Summary: UCLA researchers have developed a novel electrochemical capacitive energy storage device with high energy and power density, addressing limitations in current energy storage technologies and meeting the demands of increasing electrification. Background: Current energy storage devices, such as lithium-ion batteries and electrochemical capacitors,...

Published: 4/28/2025 | Inventor(s): Bruce Dunn, George Gruner, John Wang, Sarah Tolbert, Torsten Brezesinski

Keywords(s): battery-less, battery-less IoT, Capacitor, Charge Carrier, charge collection efficiency, charge extraction, charge sharing, charge summing, charge-transfer, clean energy, electric vehicle charging, energy conversion, Energy Density, Energy Efficiency, Energy Harvesting, energy management, Energy Management System, Energy positive, energy-efficient, grid energy, Lithium Battery, Lithium-Ion Battery, material characterization, Nanoelectronics, Nanomaterials, Nanoparticles, Nanostructure, nanostructured materials, Nanotechnology, Rechargeable Battery, Rechargeable Battery Thermal Conductivity, Renewable Energy, Renewable energy sources, Solar Energy, supercharger, Surface Charge, Thermal Energy Storage, wireless energy harvesting

Category(s): Materials, Materials > Nanotechnology, Energy & Environment, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Electrical, Electrical > Electronics & Semiconductors

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