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Compounds for Reversing the Adverse Effects of Early Life Adversity During Childhood (UCLA Case No. 2021-078)

Compositions and methods for diagnosing patients with a history of early-life adversity (ELA), and for preventing, treating, or reducing psychological distress in patients with a history of ELA. Contact UCLA Technology Development Group for more information.

Published: 11/25/2025 | Inventor(s): Arpana Church

Keywords(s):

Category(s): Therapeutics > Psychiatry And Mental Health

RSA-Wearable Alertness Detecting Device (Case No. 2025-245)

Summary: UCLA researchers from the Department of Medicine-Pulmonary Disease have developed a novel wearable device to detect alertness and predict the onset of sleep for improved safety. Background: Hypersomnia and excessive daytime sleepiness (EDS) are both symptoms of a broad class of sleeping disorders including obstructive sleep apnea (OSA),...

Published: 11/25/2025 | Inventor(s): Ravi Aysola

Keywords(s): Biomonitoring, Computer Monitor, continuous sleep monitoring, CPAP, Gene Block, non-invasive monitoring, patient outcome, Philips, public health monitoring, remote monitoring, remote patient analysis, remote patient monitoring (RPM), Remote Sensing, sleep apnea, sleep monitoring, sleep monitoring and health, wearable, wearable electronics, wearable medical device, wearable medical devices, wearable sensors, wearable sensors for health

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Hospital Systems, Electrical, Electrical > Sensors, Electrical > Flexible Electronics, Platforms, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Data Analytics

Thin Bilayer Paints to Enable Passive Daytime Radiative Cooling (Case No. 2026-014)

Intro Sentence: UCLA researchers in the Department of Materials Science and Engineering have formulated a novel bilayer coating that enables high-performance passive daytime radiative cooling. Background: Conventional technologies for cooling buildings are highly energy-intensive, consuming about 19% of U.S. residential electricity and contributing...

Published: 11/17/2025 | Inventor(s): Aaswath Raman, Aryan Zaveri, Justin Louie

Keywords(s): advanced thermal control materials, advanced thermal paint, alternative cooling, background radiation, concentrated solar radiation, energy conversion, energy conversion applications, Energy Efficiency, Energy Generation & Storage, Energy Generation, Transmission, or Storage, energy management, Energy Management System, energy-efficient cooling, heat dissipation, infrared (IR) radiation, infrared-reflectance, Paint, paint architecture, passive daytime radiative cooling (PDRC), photothermal materials, pigmented coating, real-time thermal management, Renewable Energy, Renewable energy sources, solar reflectance, thermal control, thermal control materials, Thermal Energy Storage, thermal management, thermal management systems, thermal metamaterials, thermal stability, ultraviolet reflectance, visible reflectance

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Energy & Environment, Energy & Environment > Energy Transmission, Energy & Environment > Energy Efficiency, Chemical, Chemical > Coatings, Adhesives & Inks, Chemical > Industrial & Bulk Chemicals, Energy & Environment > Thermal

Method and Apparatus for Improving the Signal-To-Noise Ratio in Multi-Dimensional Magnetic Resonance Imaging Data (Case No. 2025-204)

Summary: UCLA researchers have developed a software-based denoising method that makes cardiac MRI images clearer and more reliable, enabling more accurate heart function measurements without requiring longer scan times. Background: Cardiac MRI is a powerful imaging tool for assessing heart health because it can provide detailed pictures of how the...

Published: 11/13/2025 | Inventor(s): Xiaodong Zhong, Shu-Fu Shih, Holden Wu, Kim-Lien Nguyen

Category(s): Medical Devices > Cardiac, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Software & Algorithms > Image Processing, Software & Algorithms

B Cell-Based Assay to Expand Antigen-Specific T Cells (UCLA Case No. 2025-288)

UCLA researchers from the Department of Medicine have developed a novel B cell-based assay to expand antigen-specific T cells, allowing for an efficient, patient-specific platform to generate tumor antigen-specific T cells. BACKGROUND: Adoptive T cell therapies have emerged as a promising strategy for cancer immunotherapy, enabling the expansion of...

Published: 11/6/2025 | Inventor(s): Yuanyuan Tong, Willy Hugo, Maureen Su, Melissa Lechner, Robert Prins

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Aerodynamics-Informed Design Optimization of Vehicles with Machine Learning (Case No. 2025-083)

Intro Sentence: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a machine-learning–guided aerodynamic optimization framework that accelerates the design of electric vehicles by coupling high-fidelity simulations with data-driven shape prediction. Background: Electric vehicle (EV) technologies have...

Published: 11/5/2025 | Inventor(s): Kunihiko Taira, Jonathan Tran, Kai Fukami, Daisuke Umehara, Kenta Inada, Yoshimichi Ono, Kenta Ogawa

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Materials, Materials > Functional Materials, Energy & Environment

Silyl Ether Enables Chemoproteomic Interaction and Target Engagement (SEE-CITE) (UCLA Case No. 2024-194)

UCLA researchers from the Department of Biological Chemistry have developed a chemoproteomic platform for high-coverage, site-specific mapping of small-molecule–protein interactions using a cleavable silyl ether–based photoaffinity probe design. BACKGROUND: Small molecule drugs rely on specific and selective interactions with protein targets...

Published: 11/4/2025 | Inventor(s): Keriann Backus

Keywords(s):

Category(s): Life Science Research Tools > Mass Spectrometry, Life Science Research Tools > Research Methods, Therapeutics > Oncology

Pancreas Cancer Immunotherapy using Cationic Lipid and Polymer Nanocarriers for co-delivery of KRAS Neoantigens and STING or other immunomodulators to boost the Cancer Immunity Cycle and Treat Liver Metastasis (UCLA Case No. 2024-076)

UCLA researchers have developed a translational immunotherapy platform that leverages nanoparticle-based delivery of tumor-associated signals and immune-stimulatory molecules to drive localized immune activation in metastatic pancreatic cancer. This approach is designed to initiate de novo immune priming and recondition the tumor microenvironment in...

Published: 10/29/2025 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Vaccines, Platforms > Drug Delivery

Histone H1 as a Therapeutic Target for Fibrosis (UCLA Case No. 2023-148)

UCLA researchers from the David Geffen School of Medicine have identified linker histone H1 as a critical regulator of pathologic gene expression and cellular mechanics, establishing its potential role as a therapeutic target for the treatment of fibrosis. BACKGROUND: Heart failure affects ~6 million Americans and has a 5-year survival rate of ~50%...

Published: 10/29/2025 | Inventor(s): Thomas Vondriska

Keywords(s):

Category(s): Therapeutics > Cardiovascular

Mucus Targeting Particles (MTPs) Technology for Sustained Drug Delivery Applications (UCLA Case No. 2020-809)

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a robust nanoparticle technology for effective, sustained-release ocular drug delivery. BACKGROUND: Topically applied therapeutics are the common mode of delivery for treating ocular diseases, ranging from chronic conditions like glaucoma to acute inflammation...

Published: 10/24/2025 | Inventor(s): Nasim Annabi, Shima Gholizadeh, Reza Dana

Keywords(s):

Category(s): Therapeutics > Ophthalmology, Materials > Nanotechnology, Platforms > Drug Delivery

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