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Soft Robotic Irrigation, Cleansing, Evacuating, and Drying Device for Use on Skin or Tissue (Case No. 2023-284)

Summary: UCLA researchers from the Department Medicine have developed a novel robotic system for tissue and skin irrigation and cleansing during medical procedures. Background: Inadequate or improper hygiene practices during medical procedures may result in an increased risk of infection and postoperative complications. Traditional cleaning methods...

Published: 4/1/2025 | Inventor(s): Henry Hoang, Matthew Carroll, Jennifer Kallini, Mahruq Siddiqui

Keywords(s): Medical Device, Medical Devices and Materials, Smart medical device, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Hospital Systems, Medical Devices > Surgical Tools

Mechanical Cutaneous Nerve Stimulation for Reducing Epileptic Seizures and Perceived Pain (Case No. 2016-686-3)

Summary: UCLA researchers have developed a novel, non-invasive pain management device that uses mechanical vibrations to activate cutaneous sensory fibers, reducing epileptic seizures, masking pain perception and alleviating associated symptoms. Background: Unexpected death due to epilepsy is a pressing concern, with an estimated incidence of 1.2...

Published: 4/1/2025 | Inventor(s): Ronald Harper, Eberhardt Sauerland, Christopher Degiorgio

Keywords(s): low-power device, Medical Device, Medical Devices and Materials, minimally invasive device, Neuropathology, Neurostimulation, non-invasive, Pain Treatment, sample-to-answer devices, Semiconductor Device, Smart medical device, Stroke, Transcutaneous Electrical Nerve Stimulation, Vibration monitoring, Vibration sensing, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > CNS and Neurology

KHK Inhibitors as Agents for the Treatment of Cancer and Metabolic Syndrome (UCLA Case No. 2021-222)

UCLA researchers in the Department of Chemistry and Biochemistry have synthesized novel KHK inhibitors that can result in anticancer drugs targeting cancer metabolism. BACKGROUND: Fructose is a naturally occurring sugar found in fruits and vegetables, and is an integral part of the human diet. In comparison to its functional isomer, glucose, which...

Published: 3/31/2025 | Inventor(s): Heather Christofk, Michael Jung

Keywords(s): Cancer, cancer metabolism, metabolism, Oncology (Small Molecules, Peptides and Antibodies), small molecules

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

Method for Non-invasive Assessment of Pressure and Cardiac Efficiency (Case No. 2024-258)

Summary: Researchers in the Department of Medicine and Radiological Sciences at UCLA have developed a novel computational model for estimating ventricular mechanical efficiency using routine clinical exam practices. Background: Congenital heart disease (CHD) involves complex heart defects that make it harder for the heart to pump blood effectively....

Published: 3/25/2025 | Inventor(s): Kim-Lien Nguyen, Sanjib Gurung, John Finn

Keywords(s): acute myocardial infarction, Blood Pressure, Catheterization, heart disease mitigation, heart failure, heart support, hemodynamic monitoring, ventricular system

Category(s): Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems, Therapeutics > Inflammation And Inflammatory Diseases, Medical Devices > Medical Imaging, Software & Algorithms > Bioinformatics

Aydogan Ozcan - Signal Processing Technology Portfolio

Diffractive Waveguides (Case No. 2025-012) Innovation: Professor Aydogan Ozcan and his team have developed diffractive waveguides designed for optimized transmission across spectral, spatial, and polarization-specific applications. These diffractive waveguides can be cascaded together to operate at any desired wavelength simultaneously. Additionally,...

Published: 3/24/2025 | Inventor(s):

Keywords(s):

Category(s): Electrical, Electrical > Signal Processing, Electrical > Electronics & Semiconductors, Electrical > Instrumentation, Optics & Photonics

Bone Depth Gauge Design and Deployable Mechanism (Case No. 2024-185)

Summary: Researchers in the Department of Head and Neck Surgery at UCLA have developed a novel bone depth gauge and deployable mechanism for orthopaedic screw insertion. Background: Orthopaedic screws are typically used in surgeries to treat fractures that may have been caused intentionally, such as for tumor resection or joint replacement, or...

Published: 3/24/2025 | Inventor(s): Ashley Kita, Eric Smith, Rhorie Kerr

Keywords(s): bone health, Invasiveness Of Surgical Procedures, Orthopaedics, Orthopedics and Prosthetics (O & P), Surgical Instrument, surgical tool

Category(s): Diagnostic Markers > Aging, Mechanical > Sensors, Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease, Therapeutics > Inflammation And Inflammatory Diseases

AI-Powered System for Objective Surgical Skill Assessment in Open Procedures (Case No. 2025-207)

Summary: UCLA researchers in the Department of Surgery have developed a deep-learning architecture to efficiently and accurately assess surgeon skill level for improved medical training. TITLE: AI-Powered System for Objective Surgical Skill Assessment in Open Procedures Background: Objectively assessing surgical trainee performance during open...

Published: 3/21/2025 | Inventor(s): Peyman Benharash, Armin Alipour

Keywords(s): AI, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, deep-learning analysis algorithms, Education technology, image-guided surgery, medical bias reduction, Quality Control, Surgery, Surgical Instrument, Surgical Tools, teaching

Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools > Research Methods, Medical Devices > Hospital Systems, Medical Devices > Monitoring And Recording Systems, Medical Devices > Surgical Tools, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Communication & Networking, Software & Algorithms > Digital Health

Saliva Anti-SSA/Ro IgA1 Differentiates Sjögren’s from Non-Sjögren’s Syndrome Patients (UCLA Case No. 2023-292)

UCLA researchers in the Department of Dentistry have developed a novel methodology to accurately differentiate patients with Sjögren’s Disease from non-Sjögren’s Disease patients by monitoring saliva IgA1 forms, enabling more accurate tracking of disease progression. BACKGROUND: The presence and detection of autoantibodies within...

Published: 3/14/2025 | Inventor(s): David Wong

Keywords(s):

Category(s): Therapeutics > Autoimmune, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Ophthalmology

A Data-Driven Approach to Quality Assurance for Imagers (Radiologists) Individually and Imaging Departments as a Whole (Case No. 2014-501)

Summary: UCLA researchers have developed innovative software that streamlines radiological data analysis to enhance patient outcomes, evaluate radiologist performance, and assess AI algorithms in a way that mirrors radiologist decision-making. Background: Radiological imaging is critical to disease diagnosis and treatment planning for a wide array...

Published: 3/7/2025 | Inventor(s): Dieter Enzmann, Corey Arnold, Alex Bui, William Hsu

Keywords(s): 3D tissue imaging, 3D ultrasound imaging, bioimaging, cell imaging, computational imaging, computational imaging task, Imaging, Magnetic Resonance Imaging, Magnetic Resonance Imaging Medical Physics, Magnetic Resonance Imaging Pathology, Magnetic Resonance Imaging Spin Polarization, Medical Imaging, Molecular Imaging, multi-contrast imaging, non-invasive imaging, Radiology, Radiology / Radiomitigation, three dimensional imaging

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Digital Health, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems

Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

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