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Analoging and SAR-Based Chemical Approach to Improve the Therapeutic Potency of Small-Molecule Inhibitors of Metastasis (UCLA Case No. 2024-116)
UCLA researchers in the Department of Molecular and Medical Pharmacology have developed an analoging and SAR-based chemical approach to generate novel, safe, and effective small-molecule inhibitors for preventing and treating cancer metastasis. BACKGROUND: The limited understanding of the biological mechanisms underlying metastasis in clear cell renal...
Published: 5/14/2025
|
Inventor(s):
Lily Wu
,
Moe Ishihara
,
Robert Damoiseaux
,
Stuart Conway
Keywords(s):
Cancer
,
Metastasis
,
Oncology (Small Molecules, Peptides and Antibodies)
,
Small molecule therapeutics
,
small molecules
Category(s):
Therapeutics > Oncology
Mechanical Neural Network Driven by Flexure-Based, Meso-Scale, Bidirectional Thermal Actuators (Case No. 2024-235)
Summary: UCLA researchers in the Department of Mechanical Engineering have developed a novel bidirectional thermal linear transducer for active vibration dampening and high precision manufacturing equipment. Background: Metamaterials are engineered structures that demonstrate properties not commonly found in natural materials. To date, most...
Published: 5/14/2025
|
Inventor(s):
Jonathan Hopkins
,
Pietro Sainaghi
,
Michael Cullinan
,
Andrew Gray
Keywords(s):
Category(s):
Materials
,
Materials > Functional Materials
,
Materials > Fabrication Technologies
,
Materials > Construction Materials
,
Materials > Composite Materials
,
Mechanical
,
Mechanical > Aeronautics & Aerospace
,
Mechanical > Sensors
,
Mechanical > Micro-Electromechanical Systems (Mems)
,
Mechanical > Mechanical Systems
Batch Processing for Imaris Stitcher (Case No. 2025-089)
Summary: Researchers in UCLA’s Department of Neurobiology have developed a novel software tool that enhances the capabilities of Imaris Stitcher. The tool enables batch processing and automated execution of multiple image stitching jobs, significantly improving workflow efficiency and reducing hands-on time. This results in readily available,...
Published: 5/13/2025
|
Inventor(s):
Ian Bowman
,
Mitchell Rudd
,
Hong Wei Dong
Keywords(s):
3D tissue imaging
,
3D ultrasound imaging
,
Artifical Intelligence (Machine Learning, Data Mining)
,
Artificial Intelligence
,
artificial intelligence algorithms
,
artificial intelligence augmentation
,
artificial intelligence/machine learning models
,
artificial-intelligent materials
,
bioimaging
,
Cell Counting/Imaging
,
cell imaging
,
cell mapping
,
computational imaging
,
Data Acquisition
,
Data Aggregator
,
Data Analytics
,
Data Recovery
,
Data Structure
,
Fluorescence Microscope
,
histopathology images
,
Image Analysis
,
image restoration
,
image signal processing
,
Imaging
,
Magnetic Resonance Imaging
,
Medical artificial intelligence (AI)
,
Medical Imaging
,
Microscope
,
Microscopy
,
Microscopy And Imaging
,
Molecular Imaging
,
multi-contrast imaging
,
Neuroimaging
,
non-invasive imaging
,
pathology image analysis
,
Phase-Contrast Imaging
,
three dimensional imaging
,
volumetric image
Category(s):
Software & Algorithms
,
Software & Algorithms > AI Algorithms
,
Software & Algorithms > Digital Health
,
Software & Algorithms > Image Processing
Methods of Electrode Configurations and Montages to Achieve Spatial Selectivity of Nerve Stimulation (Case No. 2024-277)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel method for spatially selective electrical nerve stimulation. Background: Peripheral nerve stimulation (PNS) is a common form of treatment for various ailments, such as chronic pain. This approach offers a non-pharmacological and minimally invasive option....
Published: 5/13/2025
|
Inventor(s):
Jonathan Brand
,
Wentai Liu
Keywords(s):
Consumer Electronics
,
Digital Electronics
,
Electrode
,
Electrode 3D Printing
,
electrodes
,
Electroencephalography (EEG)
,
Flexible Electronics
,
Machine Learning Pain Management
,
Neuropsychological Test
,
Optoelectronics
,
Organic Electronics
,
Pain Treatment
,
Paint
,
Printed Electronics
,
Psychiatry / Mental Health
,
Psychology
,
Psych
other
apy
,
soft electronics
,
Stretchable electrodes
,
tissue-electronic interface
,
wearable electronics
Category(s):
Electrical
,
Electrical > Instrumentation
,
Electrical > Flexible Electronics
,
Medical Devices
,
Medical Devices > Neural Stimulation
,
Therapeutics
,
Therapeutics > Psychiatry And Mental Health
Methods for Building RNA Organelles in Vitro (UCLA Case No. 2023-286)
UCLA researchers from the Department of Bioengineering have developed artificial RNA sequences that can form condensates in vitro, allowing customization of cellular function in membrane-less organelles. BACKGROUND: RNA condensates are intracellular membrane-less compartments formed by phase separation, involving RNA and proteins. These RNA condensates...
Published: 5/12/2025
|
Inventor(s):
Elisa Franco
Keywords(s):
Nanotechnology
,
RNA
,
synthetic biology
Category(s):
Life Science Research Tools > Research Methods
,
Life Science Research Tools > Plasmids/Vectors
Encapsulation of Fire-Resistant Materials in Adhesive Polymeric Carriers for Fire Prevention (Case No. 2025-240)
Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel system for integrating fire-retardant compounds within an adhesive and sprayable material. Background: Fire management traditionally relies on the use of synthetic materials containing ammonium polyphosphate (APP), which are effective in fire suppression...
Published: 5/12/2025
|
Inventor(s):
Paul Weiss
,
Erika Lopez Lara
Keywords(s):
antimicrobial materials
,
Composite Materials
,
Construction Materials
,
fire
,
fire resistant materials
,
fire resistant materials and nanotechnology
,
fire retardant
,
fire tech nanomaterials
,
Functional Materials
,
intercalated materials
,
Materials
,
Medical Devices and Materials
,
meta materials
,
microarchitectured materials
,
Nanomaterials
,
nanostructured materials
,
palisades
,
phase change materials
,
phot
other
mal materials
,
safe materials
,
wildfire
,
wildfire prevention
Category(s):
Materials
,
Materials > Fabrication Technologies
,
Materials > Functional Materials
,
Energy & Environment
Efficient One-Step Chemical Conversion of MXene Into Quantum Dots (Case No. 2025-246)
Summary: UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel one-step method for producing MXene quantum dots with precise size control in an environmentally safe manner. Background: Quantum dots are widely used in bioimaging due to their tunable optical, electrical, and chemical properties. However, traditional...
Published: 5/6/2025
|
Inventor(s):
Paul Weiss
,
Haiyue Huang
,
Judy Cheng
Keywords(s):
Biochemistry
,
bioimaging
,
Biomaterial
,
Catalysts
,
Chemical
,
Chemical Manufacturing & Industrial/Bulk Chemicals
,
energy conversion
,
energy conversion applications
,
Functional Materials
,
labeling
,
material science
,
Materials
,
Nanomaterials
,
photoluminescence
,
Quantum Dot
Category(s):
Chemical
,
Chemical > Synthesis
,
Materials
,
Materials > Semiconducting Materials
Emissions-Free Olefin Synthesis via Concentrated Solar-Thermal Pyrolysis for Cleaner Plastics (Case No. 2025-008)
Summary: UCLA researchers in the department of mechanical and aerospace engineering have developed a novel technology that utilizes concentrated solar radiation to convert petroleum refinery hydrocarbons into light olefins with no CO2 emissions and generates a high-value graphitic carbon co-product. Title: Emissions-Free Olefin Synthesis via Concentrated...
Published: 5/6/2025
|
Inventor(s):
Anil Nair
,
Raymond Spearrin
,
Barathan Jeevaretanam
Keywords(s):
bulk material
,
clean material production
,
Composite Material
,
Composite Materials
,
Concentrated Solar Power
,
Concentrated Solar Power Chemical Engineering
,
concentrated solar radiation
,
Construction Materials
,
emission free materials
,
ethylene
,
fire resistant materials
,
Functional Materials
,
graphitic carbon
,
HDPE
,
high density polyethylene
,
intercalated materials
,
LDPE
,
light olefin
,
low density polyethylene
,
material characterization
,
Material for Enhanced Photoprotection
,
material science
,
Materials
,
Medical Devices and Materials
,
Nanomaterials
,
olefin
,
olefin synthesis
,
plastic
,
plastic fabrication
,
plastic production
,
plastics
,
polypropylene
,
propylene
,
pyrolysis
,
Raw materials supplier
,
safe materials
,
Smart Material
,
zero emissions
Category(s):
Materials
,
Materials > Functional Materials
,
Materials > Fabrication Technologies
,
Energy & Environment
Apparatus and Method for Low-Power EMG and EEG Devices for HMI (Case No. 2023-146)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed compact, low-power neural signal sensing solutions to enhance human-machine interfaces (HMI), including AR/VR systems. Background: Electrogram technologies, such as electroencephalogram (EEG) and electromyography (EMG), are widely used to capture biological...
Published: 5/14/2025
|
Inventor(s):
Aydin Babakhani
,
Sepideh Nouri
Keywords(s):
Antennas/Wireless
,
Augmented Reality
,
Biosensor
,
Brain computer interface
,
brain machine interface
,
Electroencephalography
,
Electroencephalography (EEG)
,
energy-efficient wireless communication
,
Extended reality
,
Human/Brain computer interfaces (BCI/HCI)
,
Microelectronics
,
motion detection
,
on-eyelid sensor
,
Radar / Antennae
,
real-time sensing/monitoring/tracking
,
Remote Sensing
,
self-powered wireless sensor solutions
,
smart sensing
,
Software & Algorithms
,
Virtual Reality
,
wearable electronics
,
wearable sensors
Category(s):
Electrical > Sensors
,
Electrical > Electronics & Semiconductors
,
Electrical
,
Software & Algorithms
,
Software & Algorithms > Ar/Vr
Charge Storage Device Architecture for Increased Energy and Power Density (Case No. 2009-392)
Summary: UCLA researchers have developed a novel electrochemical capacitive energy storage device with high energy and power density, addressing limitations in current energy storage technologies and meeting the demands of increasing electrification. Background: Current energy storage devices, such as lithium-ion batteries and electrochemical capacitors,...
Published: 4/28/2025
|
Inventor(s):
Bruce Dunn
,
George Gruner
,
John Wang
,
Sarah Tolbert
,
Torsten Brezesinski
Keywords(s):
battery-less
,
battery-less IoT
,
Capacitor
,
Charge Carrier
,
charge collection efficiency
,
charge extraction
,
charge sharing
,
charge summing
,
charge-transfer
,
clean energy
,
electric vehicle charging
,
energy conversion
,
Energy Density
,
Energy Efficiency
,
Energy Harvesting
,
energy management
,
Energy Management System
,
Energy positive
,
energy-efficient
,
grid energy
,
Lithium Battery
,
Lithium-Ion Battery
,
material characterization
,
Nanoelectronics
,
Nanomaterials
,
Nanoparticles
,
Nanostructure
,
nanostructured materials
,
Nanotechnology
,
Rechargeable Battery
,
Rechargeable Battery Thermal Conductivity
,
Renewable Energy
,
Renewable energy sources
,
Solar Energy
,
supercharger
,
Surface Charge
,
Thermal Energy Storage
,
wireless energy harvesting
Category(s):
Materials
,
Materials > Nanotechnology
,
Energy & Environment
,
Energy & Environment > Energy Efficiency
,
Energy & Environment > Energy Storage
,
Electrical
,
Electrical > Electronics & Semiconductors
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