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Targeting Plasma Extracellular Vesicles as Therapy for Severe Bacterial Pneumonia (UCLA Case No. 2025-274)

UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have identified a novel method of targeting plasma extracellular vesicles to help suppress inflammation and infection during severe bacterial pneumonia. BACKGROUND: Direct and indirect lung injury such as through pneumonia or following abdominal infections can lead to...

Published: 6/27/2025 | Inventor(s): Jae Woo Lee

Keywords(s):

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary

Use of Endogenous Plasma Extracellular Vesicles as an Adjuvant Therapeutic for Pneumonia (UCLA Case No. 2025-236)

UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have developed a novel therapeutic approach using human extracellular vesicles (EVs) to block harmful effects of bacterial outer membrane vesicles (OMVs) in Pseudomonas aeruginosa pneumonia. This strategy aims to reduce inflammation, disrupt bacterial communication, and...

Published: 6/27/2025 | Inventor(s): Jae Woo Lee

Keywords(s):

Category(s): Therapeutics > Respiratory And Pulmonary, Therapeutics > Infectious Diseases

Ingestible Device for Medical Interaction With the Gastrointestinal Tract and Surrounding Tissues (Case No. 2024-226)

Summary: UCLA researchers have conceptualized an ingestible, self-powered, and wireless capsule that can be used to effectively diagnose and treat gastrointestinal disorders. Background: Gastrointestinal (GI) disorders, including conditions like irritable bowel syndrome, Crohn’s disease, and gastroparesis, impact millions of people worldwide...

Published: 6/27/2025 | Inventor(s): Wentai Liu, Ryan Kochis, Brian Arianpour, Alejandro Miron Jabalera

Keywords(s): Biosensor, brain-gut microbiome, Gastroenterology, Gastroenterology & Digestive Disease, gastrointestinal (GI) tract diseases, gut inflammation, Human Gastrointestinal Tract, minimally invasive device, Neuromodulation, wireless capsule endoscopy

Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Gastroenterology, Software & Algorithms > Digital Health, Medical Devices > Monitoring And Recording Systems, Mechanical > Sensors, Chemical > Chemical Sensors, Life Science Research Tools > Screening Libraries

Monitoring Structural Health Using Diffractive Optical Processors (Case No. 2025-201)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel structural health monitoring system that is highly accurate and cost effective, addressing limitations in current infrastructure and civil health monitoring and a rise in public safety concerns. Background: The need for structural health monitoring...

Published: 6/25/2025 | Inventor(s): Aydogan Ozcan, Ertugrul Taciroglu, Yuntian Wang, Yuhang Li

Keywords(s): 3D structures, Adaptive Optics, AI-generated images and content, all-optical diffractive computing, all-optical transformation, analog computing, analog optical computing, Analogue Electronics, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, artificial-intelligent materials, civil engineering, civil infrastructure, civil monitoring, computational imaging, computational imaging task, Construction, deep diffractive network, Diffraction, diffractive design, diffractive image reconstruction, diffractive network, diffractive processor, diffractive surface, digital image reconstruction, electromagnetic spectrum, Electro-Optics, Image Analysis, Image Processing, Image Resolution, image restoration, image signal processing, Imaging, Infrastructure, Lens (Optics), linear optics, Nanostructure, optical processor, optically-guided structural monitoring, Optics, passive light-matter interactions, security imaging, Signal Reconstruction, Structural health monitoring, structural health monitoring (SHM), structure monitoring, Structures

Category(s): Electrical, Electrical > Signal Processing, Electrical > Imaging, Materials, Materials > Construction Materials, Electrical > Visual Computing, Electrical > Computing Hardware, Electrical > Instrumentation, Energy & Environment, Energy & Environment > Energy Efficiency, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Software & Algorithms > Programs

Gut Bacterial Detoxification of Methylmercury (UCLA Case No. 2023-188)

UCLA researchers from the Department of Integrative Biology and Physiology have developed a microbiome-based therapy for methylmercury detoxification, leveraging a genetically engineered probiotic that neutralizes methlymercury in the gut prior to systemic absorption with potential applications in acute detoxification, preventative healthcare, and environmental...

Published: 6/24/2025 | Inventor(s): Elaine Hsiao

Keywords(s):

Category(s): Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology

Multi-Sightline Photonic Spectroscopic Unit for Sensing (Case No. 2025-164)

Summary: UCLA researchers from the Department of Physics & Astronomy have developed a compact, low-cost, energy-efficient, and high-resolution photonic spectrograph platform that enables quantitative sensing of atmospheric gases such as methane across multiple lines of sight. Background: Accurate, high-resolution monitoring of methane emissions...

Published: 6/24/2025 | Inventor(s): Pradip Gatkine

Keywords(s):

Category(s): Chemical > Chemical Sensors, Chemical, Electrical > Electronics & Semiconductors, Electrical > Instrumentation, Electrical > Sensors, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Transmission, Optics & Photonics > Spectroscopy

Fish Oil Plus Diet for Prostate Health (UCLA Case No. 2024-092)

UCLA researchers from the Department of Urology have identified a dietary intervention that may slow prostate cancer progression, offering a promising accessible, safe, and non-invasive approach to managing prostate health. BACKGROUND: Prostate cancer is the second most commonly diagnosed cancer in the United States and the fifth leading cause of death...

Published: 6/20/2025 | Inventor(s): William Aronson

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

Vectors Combining Anti-Sickling Beta-AS3-Globin with Anti BCL11A ShRNAmir to Treat Beta-Hemoglobinopathies (UCLA Case No. 2021-190)

UCLA researchers from the Department of Microbiology, Immunology and Molecular Genetics and Pediatrics have developed a potent bi-functional lentiviral expression vector to treat sickle cell disease and beta-thalassemia. BACKGROUND: Beta-hemoglobinopathies, such as sickle cell disease and beta-thalassemia, are genetic disorders characterized by dysfunctional...

Published: 6/20/2025 | Inventor(s): Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Stem Cells And Regenerative Medicine

A Diagnostic Epigenetic Score for Determining the Effect of Biomarkers for Asthma Drug Response (UCLA Case No. 2024-106)

UCLA researchers in the Department of Computational Medicine have developed a novel machine learning algorithm to generate an accurate molecular score for determining asthma drug response. BACKGROUND: Asthma is a globally prevalent, high-burden disease marked by substantial clinical heterogeneity and variable treatment response. This heterogeneity...

Published: 6/19/2025 | Inventor(s): Elior Rahmani

Keywords(s):

Category(s): Platforms > Diagnostic Platform Technologies, Diagnostic Markers > Targets And Assays, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Therapeutics > Inflammation And Inflammatory Diseases

Reverse Engineering Vaccine Antigens (UCLA Case No. 2025-074)

UCLA researchers from the Department of Pediatrics-Allergy/Immunology have developed a novel platform to reverse engineer vaccine antigens for the prevention and treatment of infectious disease and cancer. BACKGROUND: Vaccines function by introducing antigens into a host to stimulate an immune response, providing protection against pathogens and certain...

Published: 6/19/2025 | Inventor(s): Manish Butte

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Vaccines

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