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An Acoustic Device for Large Area Single Cell Trapping and Selective Release (Case No. 2025-047)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an acoustic microfluidic platform that offers a cost-effective and practical approach for handling individual cells at the microscale. Background: Single-cell manipulation is essential for understanding cellular behavior, disease progression, and therapeutic...

Published: 1/13/2026 | Inventor(s): Pei-Yu Chiou, Xiang Zhang

Keywords(s): acoustic microfluidics, acoustic potential wells, acoustics, cell proliferation, cell viability, Diagnostic Platform Technologies (E.G. Microfluidics), diagnostic platforms, Digital Microfluidics, disposable microfluidic platforms, high throughput, high throughput assays, high throughput testing, High-Content Screening, high-throughput cell handling, low-cost fabrication, MEMS, MEMS metasurface, micro-electromechanical systems (MEMS), Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared laser, photolithography-free fabrication, research instrumentation, scalable platform, single cell analysis, single cell analysis and testing, Single cell data, single-cell handling, single-cell manipulation, single-cell resolution, single-cell trapping

Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Mechanical, Mechanical > Instrumentation, Platforms, Platforms > Diagnostic Platform Technologies

Peri-Operative Cancer Therapy to Preserve Anti-Tumor Immune Surveillance (UCLA Case No. 2025-257)

UCLA Researchers from the Department of Surgery have developed a novel approach to preserve anti-tumor immunity in the peri-operative period through modulation of clinically relevant molecular and cellular targets. BACKGROUND: Surgical resection with curative intent is a mainstay of treatment for many solid tumors. However, even when the tumor is macroscopically...

Published: 1/12/2026 | Inventor(s): Tyler McCaw

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Oral-Gut-Brain Axis Virome/Microbiome for Periodontitis, Irritable Bowel Disease and Alzheimer’s Disease Diagnostics (UCLA Case No. 2024-222)

UCLA researchers in the School of Dentistry and section of Biosystems and Function have developed a novel diagnostic protocol to accurately categorize both the virome and microbiome of the oral-gut-brain axis for periodontitis, irritable bowel disease, and Alzheimer’s disease pathologies. BACKGROUND: Humans are host to a large and diverse set...

Published: 1/7/2026 | Inventor(s): Yvonne Kapila

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

Custom Isobaric Tandem Mass Spectrometry Quantitative Chemoproteomics Enabled by Dialkoxydiphenylsilane (DADPS) Capture Reagents (UCLA Case No. 2023-113)

UCLA researchers in the Department of Biological Chemistry have developed a chemoproteomics-based method for improved and efficient protein and drug studies. BACKGROUND: Quantitative proteomics is a method scientists use to find out how much of each protein is in a sample. It is used to compare protein levels in different situations. This information...

Published: 1/7/2026 | Inventor(s): Keriann Backus

Keywords(s):

Category(s): Life Science Research Tools > Mass Spectrometry

A Solid-Phase Compatible Dialkoxydiphenylsilane (DADPS) Reagent for Chemoproteomics (UCLA Case No. 2023-017)

UCLA researchers in the Department of Biological Chemistry have developed two novel fluorenylmethyl carbamate functionalized dialkoxydiphenylsilane (FMOC-DADPS) reagents that provide unprecedented compatibility with solid-phase chemistry, enabling higher yield and purity in the synthesis of DADPS-based chemoproteomics capture reagents. BACKGROUND:...

Published: 1/7/2026 | Inventor(s): Keriann Backus

Keywords(s):

Category(s): Life Science Research Tools > Other Reagents, Life Science Research Tools > Research Methods

Immobilized Peptides for Rare Earth Element Separation (Case No. 2026-031)

Summary: UCLA researchers in the Department of Materials Science and Engineering have developed a bead-based chromatography platform that employs immobilized peptides for improved rare earth element separation and recovery. Background: Rare earth elements (REEs) are critical inputs for renewable energy technologies, electric vehicles, advanced electronics,...

Published: 1/5/2026 | Inventor(s): Aaron Moment, Zihang Su

Keywords(s): bulk material, clean material production, Composite Material, Composite Materials, Construction Materials, Functional Materials, material characterization, material science, Materials, meta materials, Nanomaterials, Peptide, Peptide Base, peptides, rare earth element separation, Raw materials supplier, safe materials, Smart Material, sustainable rare earth recovery

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Energy & Environment, Materials > Metals

Generation of Therapeutic Human Anti-Trop-2 Extracellular Domain Antibodies (UCLA Case No. 2026-026)

UCLA researchers from the Department of Molecular and Medical Pharmacology and the Department of Microbiology, Immunology and Molecular Genetics have developed a panel of human antibodies and chimeric antigen receptors targeting Trop-2, providing diagnostic and therapeutic resources for targeting Trop2-driven cancer. BACKGROUND: Trophoblast cell surface...

Published: 12/23/2025 | Inventor(s): Tanya Stoyanova, Owen Witte

Keywords(s):

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Antibodies, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Combinatorial RNA-LNP Immunotherapy for Enhanced Pattern Recognition Receptor (PRR) Engagement, Targeted Dendritic Cell (DC) Activation, and Versatile (UCLA Case No. 2025-237)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a cancer immunotherapy platform that uses lipid nanoparticle (LNP) delivery of modified RNA constructs to activate dendritic cells, enhance CD8+ T-cell priming, and drive potent anti-tumor immunity. BACKGROUND: Effective cancer immunotherapy requires robust activation...

Published: 12/23/2025 | Inventor(s): Caius Radu

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Vaccines, Therapeutics > Infectious Diseases

Phenotyping Single Ventricle Physiology Using Electronic Health Records (Case Nos. 2025-322 and 2025-323)

Summary: UCLA researchers have created a cutting-edge, automated phenotyping tool that harnesses electronic health records to enable rapid and precise identification of single ventricle physiology (SVP), especially in neonatal and pediatric populations. Background: Single ventricle physiology (SVP) is a rare heart condition that develops before birth...

Published: 1/6/2026 | Inventor(s): Kim-Lien Nguyen, William Hsu, Hang Xu

Keywords(s): Algorithm, cardiac cycle, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular monitoring, cardiovascular prediction, Computer-Aided Diagnosis, heart disease mitigation, heart support, medical automation technology, Medical Device, medical device cardiac monitoring, Medical diagnostics, Medical Guideline, non-invasive cardiac monitoring, Smart medical device, Software, Software & Algorithms, Software Development Tools

Category(s): Diagnostic Markers, Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems

Mental Health Functional Movement Scale (MH-FMS) (Case No. 2025-021)

Summary: UCLA researchers in the Department of Psychiatry and Behavioral Sciences have created a novel assessment platform that objectively measures how the brain, body, and autonomic nervous system respond to stress and regulate emotion during real-time movement. By integrating a shear-stress–based neurovascular framework with a polyvagal-informed...

Published: 12/17/2025 | Inventor(s): Naser Ahmadi, Mike Ramirez, Julien Pineau

Keywords(s): blood flow management, Cardiovascular, cellular, clinical care methodology, clinical decision support, Clinical decision support system, clinical mental health, Clinical tool, exercise physiology, Hemodynamics, Mental health, neurobehavioral impairment, Neurocognitive, Neurocognitive Scientific Method, neurodevelopment, neurological disorders, Neuropsychological Test, neuroscience, Neurostimulation, Psychiatry / Mental Health

Category(s): Diagnostic Markers, Life Science Research Tools, Medical Devices, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > Psychiatry And Mental Health

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