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3D Scaffold for T Cell Delivery and Suppression of Tregs for Solid Tumors (UCLA Case No. 2020-193)

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a small and biodegradable implant that when placed adjacent to solid tumors, enhances immune response to cancer cells. BACKGROUND: The body’s immune system uses proteins called antibodies to train the immune response to foreign pathogens. This mechanism can combat...

Published: 12/3/2024 | Inventor(s): Manish Butte

Keywords(s): cytokines, Drug Delivery, Immunotherapy, Nanoparticles, scaffolds, solid tumors, T-cell activation, t-cells

Category(s): Platforms > Drug Delivery > Nanoparticles

VEViD: Vision Enhancement via Virtual Diffraction and Coherent Detection (Case No. 2023-083)

Summary: UCLA researchers in the Department of Electrical Engineering have developed an innovative approach to improve image quality when lighting conditions are suboptimal, that can be readily integrated with different machine learning techniques for more accurate object and face recognition. Background: The computer vision market size was valued...

Published: 12/2/2024 | Inventor(s): Bahram Jalali, Callen MacPhee

Keywords(s):

Category(s): Electrical, Electrical > Signal Processing, Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Security & Privacy, Optics & Photonics, Electrical > Displays, Electrical > Imaging, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Software & Algorithms > Artificial Intelligence & Machine Learning

Free Silicone Aspirator (Case No. 2020-490)

Summary: Researchers in the Department of Plastic Surgery at UCLA have developed a new and improved drainage system for the removal of silicone from ruptured breast implants. Background: The removal of ruptured silicone breast implants has become increasingly common. Free silicone, a sticky and gelatinous substance, tends to adhere to tissue, making...

Published: 11/21/2024 | Inventor(s): Jaco Festekjian

Keywords(s): Aesthetic Medicine, Biological nutrient removal, biomedical implantation, Implant (Medicine), Silicon

Category(s): Therapeutics > Aesthetic Medicine, Medical Devices > Surgical Tools, Medical Devices > Prosthetics, Mechanical > Manufacturing

Electrolyzer Column (Case No. 2025-032)

Summary: UCLA researchers in the Department of Chemical Engineering have developed a novel system for efficiently converting carbon dioxide to liquid fuel for sustainable energy storage and utilization. Background: The conversion of carbon dioxide (CO2) into high-energy-density liquid fuel presents a promising pathway for sustainable energy storage...

Published: 11/20/2024 | Inventor(s): Carlos Morales Guio, Philippe Sautet

Keywords(s): Carbon Dioxide, clean energy, conversion efficiency photoelectric, Electrocatalyst, energy conversion, Energy Generation & Storage, power conversion efficiency, Power Electronics, Renewable Energy, renewable fuel

Category(s): Energy & Environment > Energy Storage > Fuel Cells, Energy & Environment > Energy Efficiency

CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)

UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...

Published: 11/22/2024 | Inventor(s): Wenlin Zhang, Anthony Aldave

Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing

In-Situ Stochastic Computing in Memory (Case No. 2024-121)

Summary: Researchers in the UCLA Department of Electrical and Computer Engineering have developed a data-converter-free in-memory computing circuit that greatly reduces data processing latencies. Background: Low latency and low power computing circuitry is in high demand for artificial intelligence (AI) / machine learning (ML) applications. Compute...

Published: 11/19/2024 | Inventor(s): Sudhakar Pamarti, Jiyue Yang

Keywords(s):

Category(s): Electrical, Electrical > Computing Hardware, Electrical > Electronics & Semiconductors, Software & Algorithms > Artificial Intelligence & Machine Learning

Interleaved Radial Amine CEST and Sodium (INTERLACED) NMR Pulse Sequence (Case No. 2024-069)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a novel MRI modality that simultaneously utilizes multiple nuclei to enhance scanning capabilities while reducing scanning times. Background: Magnetic Resonance Imaging (MRI) is a major tool in medical diagnostics and monitoring, as well as the primary clinical research...

Published: 11/19/2024 | Inventor(s): Benjamin Ellingson, Alfredo Kolkovsky

Keywords(s): diagnostic radionuclides, Functional Magnetic Resonance Imaging, Magnetic Resonance Imaging, MRI, multiparametric MRI (mpMRI)

Category(s): Medical Devices, Medical Devices > Medical Imaging

Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)

UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...

Published: 11/18/2024 | Inventor(s): Arpana Church

Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity

Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

Compounds for Improved Psychological and Resilience Measures Associated with Physical Activity (UCLA Case No. 2022-272)

UCLA researchers from the Department of Medicine have identified microbiome and metabolic markers associated with high physical activity in an obese population, leading to possible therapies that may provide the positive effects of physical activity. BACKGROUND: It is known that physical activity has a multitude of beneficial effects on health. On...

Published: 11/18/2024 | Inventor(s): Arpana Church

Keywords(s): Bacteria, Exercise, Gastroenterology & Digestive Disease, gut-brain axis, Human Gastrointestinal Tract, metabolomics, microbiome, MRI, Nutraceuticals / Probiotics, obesity, physical activity, prebiotics, Psychology

Category(s): Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health, Therapeutics > Metabolism And Endocrinology

Novel Strategy to Produce Bi-specific Chimeric Antigen Receptors (UCLA Case No. 2024-169)

Researchers in the Department of Medicine and the Department of Microbiology, Immunology and Molecular Genetics have created novel bi-specific chimeric antigen receptors. BACKGROUND: Chimeric antigen receptors (CARs) are synthetic receptors engineered to redirect T cells towards specific targets on other cells, typically using a single chain antibody....

Published: 11/15/2024 | Inventor(s): Otto Yang

Keywords(s):

Category(s): Therapeutics > Oncology

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