Search Results - platforms+%3e+drug+delivery+%3e+nucleic+acid+platform+systems

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2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have designed and developed a protein cage which can be easily tailored to sense other proteins, opening in response, and thus delivering enclosed biological compounds across a wide variety of applications, including biosensing, molecular diagnostics, and targeted drug delivery....

Published: 9/5/2023 | Inventor(s): Todd Yeates

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Drug Delivery

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Nucleic Acids

2018-438 A DNA CONSTRUCT FOR TARGETING THERAPEUTIC MOLECULES TO DISEASED TISSUE BY IMMUNE CELLS

INTRODUCTION:UCLA researchers in the Departments of Integrative Biology & Physiology and Pathology & Laboratory Medicine have developed a novel construct for targeting therapeutic biological molecules specifically to diseased tissue, using immune cells as a delivery system. BACKGROUND:Drug delivery is the process of administering a pharmaceutical...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nucleic Acids

IRIS: Isoform Peptides from RNA Sequencing for Immunotherapy Targets Screening

UCLA Case No. 2018-916SUMMARYResearchers led by Dr. Xing from the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed a big data approach to identify targets for personalized cancer immunotherapy. BACKGROUNDImmunotherapies aim to use the patient’s own immune system to fight cancerous cells, but to be...

Published: 7/19/2023 | Inventor(s): Yi Xing, Yang Pan, Taegyun Yang, Yuanyuan Wang

Keywords(s):

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Data Analytics

Small Molecules to Facilitate Therapeutic Exon Skipping (UCLA Case No. 2009-381)

Summary Investigators at UCLA have discovered a series of small molecules to facilitate therapeutic exon skipping. The use of these identified molecules may enhance the effectiveness of antisense oligonucleotide agents currently in clinical development. Background A number of antisense oligonucleotide agents are currently in clinical trials for a wide...

Published: 2/10/2024 | Inventor(s):

Keywords(s):

Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems

2015-826 SATELLITE/HELPER VIRUS-LIKE SYSTEMS FOR AMPLIFYING RNA

Case No. 2015-826SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.BACKGROUNDThe RNA therapeutics industry is growing at a CAGR of 12% and is expected to reach $1.2 billion by 2020. These are a novel class of therapeutics,...

Published: 7/19/2023 | Inventor(s): William Gelbart, Charles Knobler, Devin Brandt, Adam Biddlecome, Richard Sportsman, Rees Garmann

Keywords(s): Drug Delivery, Life Science Research Tools, Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics

SHARPR-MPRA (Systematic High-Resolution Activation and Repression Profiling with Reporter-Tiling Massively Parallel Reporter Assay) - UCLA Case No. 2017-224

SHARPR-MPRA (Systematic High-Resolution Activation And Repression Profiling With Reporter-Tiling Massively Parallel Reporter Assay)SUMMARYUCLA researchers in the Department of Biological Chemistry have developed a method to screen hundreds to thousands of genes to identify their regulatory functions.BACKGROUNDGenetic reporter assays are used to uncover...

Published: 8/13/2024 | Inventor(s): Jason Ernst, Manolis Kellis

Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Research Methods

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools, Platforms > Drug Delivery > Nucleic Acids, Platforms > Drug Delivery > Nucleic Acid Platform Systems

DARTS: Deep Learning Augmented RNA-seq Analysis of Transcript Splicing

SummaryResearchers led by Yi Xing have developed a novel deep learning algorithm to detect alternative splicing patterns in RNA-seq dataBackgroundDevelopment of genetic sequencing tools like RNA-seq has ushered in an age of big data in genomics and transcriptomics. Collective efforts like ENCODE and the Roadmap Epigenomics Project (REP) have accelerated...

Published: 7/19/2023 | Inventor(s): Yi Xing, Zijun Zhang

Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Research Methods, Software, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Software & Algorithms > Programs

2017-773 Optimizing B Cell Epitope-Based Autoantibody Detection in Cancer Patients

Optimizing B Cell Epitope-Based Autoantibody Detection In Cancer PatientsSUMMARYUCLA researchers from the Department of Urology have invented a new approach to optimize detection of autoantibody response using Luminex microbead-based multiplex assay. This approach bypasses the difficult process of purifying whole proteins by using select combinations...

Published: 7/19/2023 | Inventor(s): Gang Zeng

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Immunotherapy, Life Science Research Tools, Nucleic Acid Platform Systems, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Therapeutics > Immunology And Immunotherapy

Improvement To Retroviral Vectors Containing The Human Ubiquitin C Promoter

SummaryUCLA researchers in the Department of Molecular Biology have developed a lentiviral vector, “pCCLc-roUBC”, containing the cellular promoter from the human ubiquitin C gene (UBC), to improve transgene expression in retroviral vectors.BackgroundGene delivery into human cells is a promising way to correct or protect against genetic alterations...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery > Nucleic Acids