Search Results - cancer+immunotherapy

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Methods to Improve Chimeric Antigen Receptor (CAR)-T Cell Efficacy Through Rational Sequence and Structural Modifications (UCLA Case No. 2020-497)

UCLA researchers in the Department of Microbiology, Immunology & Molecular Genetics have developed novel engineering methodologies for CAR molecules that overcome the tonic signaling process that leads to T cell exhaustion and poor therapy efficacy. Background: Immunotherapy has become a highly effective method to combat cancer that enhances a...

Published: 9/30/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer Immunotherapy

Category(s): Therapeutics > Oncology > Oncology Immunotherapy

Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)

Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...

Published: 10/8/2024 | Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao

Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy

Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy

Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)

UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...

Published: 6/27/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer, Cancer Immunotherapy, CAR-T cell therapy, immunosuppression, Immunosuppressive Drug, Immunotherapy, solid tumors, Tumor microenvironment, tumor vasculature, VEGF

Category(s): Therapeutics > Oncology

Strategies to Detect, Prevent and Reverse Acquired Resistance to Immune Checkpoint Blockade Therapy (UCLA Case No. 2024-085)

UCLA researchers in the Department of Medicine have uncovered novel mechanism of acquired resistance against immune checkpoint blockade therapy in melanoma patients. BACKGROUND: Immune checkpoint blockade (ICB) therapy is a type of cancer immunotherapy that targets immune system components in order to reactivate immune cells to combat tumor cells....

Published: 5/8/2024 | Inventor(s): Roger Lo

Keywords(s): acquired resistance, Apoptosis, Cancer, Cancer Immunotherapy, Immune checkpoint blockade, Immunotherapy, Melanoma, T Cell

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Full Spectrum Computer Vision for Photon Counting CT (Case No. 2024-058)

Summary: Researchers in the Department of Radiological Sciences have developed a machine learning algorithm that processes multispectral photon counting CT data for accurate medical imaging. Background: Photon counting computed tomography (PCCT) is a tremendous engineering advancement, enabling high resolution spectral imaging with myriad applications....

Published: 9/20/2024 | Inventor(s): Matthew Brown, Dieter Enzmann, John Hoffman, Michael Mcnitt-Gray

Keywords(s): AI algorithms, Algorithm, Algorithm Optical Coherence Tomography, algorithmic cancer detection, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, Artificial Neural Network Artificial Neuron, artificial-intelligent materials, Big Data, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, Cancer stem cells, cancer target, Computed tomography, CT, Deep Learning, design software, Digital Pathology, generative artificial intelligence, Genetic Algorithm, Histopathological image analysis, Histopathology, histopathology images, hyperparameter optimization, Image Analysis, Image Processing, lympathic cancers, lymphatic cancer, Medical artificial intelligence (AI), Mesenchymal Stem Cell Derived Cancer Cells, Orthotopic cancer models, Pancreatic cancer, pathology image analysis, Photon counting computed tomography (PCCT), prostate cancer, Radiology, Radiology / Radiomitigation, Software, Software & Algorithms, Software Development Tools, Software-enabled learning

Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics

Syringe Stabilization Device for Ultrasound-Guided Procedures (UCLA Case No. 2023-045)

Summary: UCLA researchers in the Department of Surgery have developed a novel, minimally invasive ultra-sounded guided metastatic mouse model and device enabling more secure and precise usage of in-plane ultrasound imaging of needles. Background: Cancer is the second leading cause of death globally and in the United States. Pancreatic cancer remains...

Published: 11/8/2023 | Inventor(s): Amanda Labora

Keywords(s): Breast Cancer, Cancer, cancer detection, Cancer Immunotherapy, Catheterization, In-plane ultrasound, Intratumoral drug delivery, Metastasis, metastatic mouse model, Mouse model, Orthotopic cancer models, Pancreatic cancer, Preclinical model development, Preclinical surgical innovation

Category(s): Life Science Research Tools, Life Science Research Tools > Animal Imaging, Life Science Research Tools > Animal Models, Medical Devices > Medical Imaging, Therapeutics, Therapeutics > Oncology, Medical Devices > Medical Imaging > Ultrasound

Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues (Case No. 2022-067)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a simple, innovative method for growing 3D cell cultures with improved organoid differentiation and reduced hypoxia-induced cell death. TITLE: Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues Background: 3D tissue culture,...

Published: 10/23/2024 | Inventor(s): Neil Lin, Marie Payne

Keywords(s): 3D Printing, Biofilm, Biomaterial 3D Printing, Biomedical Engineering, Cancer, cancer detection, Cancer Immunotherapy, Cell and tissue culture, Cell Culture, Cellular agriculture, Cultured meat, iPS/stem cells, Laminar flow, Microwell plates, organogenesis, Organoids, Personalized Pharmacotherapy, Pharmaceutical testing, Stem Cells / Regenerative Medicine, Tissue (Biology), tissue detection, Tissue Engineering, Tissue sedimentation

Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Oncology

2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning

SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...

Published: 4/9/2024 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics

2021-355 Magnetically Activated Individual Cell Sorting Using Spin Orbit Torque

SUMMARY: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a magnetically activated cell sorting method with high throughput and low-cost operation. BACKGROUND: The use of cell sorting techniques has become indispensable for many applications in biology and biomedicine. Cell sorting is particularly important...

Published: 10/4/2024 | Inventor(s): Abdon Sepulveda, Victor Estrada, Ruoda Zheng, Yilian Wang

Keywords(s): Cancer Immunotherapy, Chemical, Diagnostic Markers & Platforms, High-Throughput Screening, Imaging, Magnetic Field, Materials, Nanomaterials, Nanotechnology, T Cell

Category(s): Life Science Research Tools > Microscopy And Imaging, Materials > Nanotechnology, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging, Medical Devices > Medical Imaging