Search Results - antibody+delivery+platforms

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Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)

UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...

Published: 2/26/2024 | Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh

Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy

2018-463 REAGENT TO LABEL PROTEINS VIA LYSINE ISOPEPTIDE BONDS

Reagent to Label Proteins via Lysine Isopeptide BondsSUMMARYResearchers in the UCLA Department of Chemistry and Biochemistry and the University of Texas-Medical Center, Houston Department of Microbiology and Molecular Genetics have modified the Corynebacterium diphtheriae (C. diphtheriae) sortase enzyme so that it can be used as a bioconjugation reagent...

Published: 9/12/2023 | Inventor(s): Robert Clubb, Brendan Amer, Hung Ton-That, Chungyu Chang, Janine Fu, Scott Mcconnell

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Therapeutics, Therapeutics > Infectious Diseases

Disulfide Bioconjugation

SummaryUCLA researchers in the Department of Chemistry and Biochemistry have proposed a one-step radical mechanism for disulfide bioconjugation that overcomes many concerns associated with the free cysteine residues that result from current bioconjugation techniques.BackgroundThe post-translational modification of proteins has a number of important...

Published: 7/19/2023 | Inventor(s): Ellen Sletten, Monica Pengshung

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

2017-645 HUMANIZED ANTIBODIES TO THE EXTRACELLULAR DOMAINS OF HUMAN N-CADHERIN

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed humanized antibody therapies for invasive prostate and bladder cancers that express N-cadherin.BACKGROUNDProstate cancer is the second leading cause of cancer death among men in the United States (National Cancer Institute). Unfortunately, systemic therapies such...

Published: 3/8/2024 | Inventor(s): Anna Wu, Robert Reiter, Kirstin Zettlitz

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Gastroenterology & Digestive Disease, Life Science Research Tools, Nucleic Acids, Therapeutics & Vaccines