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2019-772: A Single Chain Antibody That Binds Tau Oligomers and Inhibits Seeding by Pathological Extracts From Alzheimer’s Disease

SUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed a method for efficiently producing tau oligomers and a single-chain antibody against oligomeric tau protein with potential for theranostic utility in the treatment of Alzheimer’s and other tauopathies.BACKGROUND:Alzheimer’s disease (AD) is the most prevalent...

Published: 9/5/2023 | Inventor(s): David Eisenberg

Keywords(s): Amyloid, Antibodies, Central Nervous System, Genetic Disease, Life Science Research Tools, Neurodegeneration Alzheimer's Disease Predictive Testing, Tau Protein

Category(s): Life Science Research Tools > Antibodies, Therapeutics > CNS and Neurology

2015-341 COMBINATIONS OF CHECKPOINT INHIBITORS AND DENDRITIC CELL VACCINES TO TREAT BRAIN CANCER

UCLA researchers in the Departments of Neurosurgery and Molecular and Medical Pharmacology have developed an autologous dendritic cell (DC) vaccine in combination with checkpoint inhibitors for the treatment of malignant brain tumors.BACKGROUND: Checkpoint inhibitor therapies, which unblock an existing immune response, or unblock the initiation of an...

Published: 7/19/2023 | Inventor(s): Robert Prins, Linda Liau

Keywords(s): Antibodies, Drug Delivery, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Oncology Immunotherapy, Therapeutics & Vaccines, Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

2014-255 Monoclonal Antibodies Against GPIHBP1

Monoclonal Antibodies Against GPIHBP1INNOVATIONResearchers at UCLA have developed monoclonal antibodies that recognize mouse and human glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1). - Rat monoclonal antibody, 11A12, against mouse GPIHBP1 - Mouse monoclonal antibody against human GPIHBP1BACKGROUNDDietary...

Published: 7/19/2023 | Inventor(s): Loren Fong, Stephen Young

Keywords(s): Antibodies, Life Science Research Tools

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools

2018-463 REAGENT TO LABEL PROTEINS VIA LYSINE ISOPEPTIDE BONDS

Reagent to Label Proteins via Lysine Isopeptide BondsSUMMARYResearchers in the UCLA Department of Chemistry and Biochemistry and the University of Texas-Medical Center, Houston Department of Microbiology and Molecular Genetics have modified the Corynebacterium diphtheriae (C. diphtheriae) sortase enzyme so that it can be used as a bioconjugation reagent...

Published: 9/12/2023 | Inventor(s): Robert Clubb, Brendan Amer, Hung Ton-That, Chungyu Chang, Janine Fu, Scott Mcconnell

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Therapeutics, Therapeutics > Infectious Diseases

Disulfide Bioconjugation

SummaryUCLA researchers in the Department of Chemistry and Biochemistry have proposed a one-step radical mechanism for disulfide bioconjugation that overcomes many concerns associated with the free cysteine residues that result from current bioconjugation techniques.BackgroundThe post-translational modification of proteins has a number of important...

Published: 7/19/2023 | Inventor(s): Ellen Sletten, Monica Pengshung

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

2014-845 ANTI-PSA IGG

Anti-PSA IgGSUMMARYResearchers at UCLA have developed chimeric IgG specific for prostate-specific antigen (PSA) in human and mouse cells.BACKGROUNDProstate-specific antigen (PSA) is a substance made by cells in the prostate gland. Physicians use high PSA levels (above 4 nanograms per milliliter) as a blood biomarker for prostate cancer. Given this,...

Published: 7/19/2023 | Inventor(s): Manuel Penichet, Tracy Wells, Gustavo Helguera

Keywords(s): Antibodies, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Oncology

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology

Hybrid IgA/IgG Polymeric Antibodies

Case 1998-610BACKGROUNDIgA is a polymeric effector molecule of the immune system that mainly acts at mucosal surfaces and is highly resistant to extreme pH conditions, whereas IgG is monomeric and acts in the blood at a narrower pH range. IgG is known for its potent complement activation and, in contrast, IgA is unable to fix complement. Combining the...

Published: 7/19/2023 | Inventor(s): Sherie Morrison, Koteswara Chintalacharuvu, Maria Coloma, Kham (Ryan) Trinh, Esther Yoo

Keywords(s): Antibodies, Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Immunology And Immunotherapy

Peptide Epitopes as Biomarkers for Prostate Cancer

Case 2009-047UCLA researchers have discovered several peptide epitopes that are potentially useful biomarkers for prostate cancer. Tests utilizing these peptides may provide more specific prostate cancer diagnosis, improved observation of progression of the disease and response to treatments.BACKGROUNDProstate cancer is the most common cancer in men...

Published: 7/19/2023 | Inventor(s): Gang Zeng

Keywords(s): Antibodies, Diagnostic Markers & Platforms, Life Science Research Tools, Oncology

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Therapeutics > Oncology

2017-645 HUMANIZED ANTIBODIES TO THE EXTRACELLULAR DOMAINS OF HUMAN N-CADHERIN

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed humanized antibody therapies for invasive prostate and bladder cancers that express N-cadherin.BACKGROUNDProstate cancer is the second leading cause of cancer death among men in the United States (National Cancer Institute). Unfortunately, systemic therapies such...

Published: 3/8/2024 | Inventor(s): Anna Wu, Robert Reiter, Kirstin Zettlitz

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Gastroenterology & Digestive Disease, Life Science Research Tools, Nucleic Acids, Therapeutics & Vaccines

Antibody Therapy for Inhibiting Bladder Cancer and Prostate Cancer Metastasis

Case 2005-098UCLA has a robust intellectual property position on antibody-based diagnostics and therapeutics against N-cadherin for the treatment and detection of prostate and bladder cancers. The research and development leading to this promising technology has been conducted by Dr. Robert Reiter, Professor of Urology and Director of UCLA’s Prostate...

Published: 7/19/2023 | Inventor(s): Robert Reiter

Keywords(s): Antibodies, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Life Science Research Tools > Antibodies, Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

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