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2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have designed and developed a protein cage which can be easily tailored to sense other proteins, opening in response, and thus delivering enclosed biological compounds across a wide variety of applications, including biosensing, molecular diagnostics, and targeted drug delivery....

Published: 9/5/2023 | Inventor(s): Todd Yeates

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Drug Delivery

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Nucleic Acids

2018-438 A DNA CONSTRUCT FOR TARGETING THERAPEUTIC MOLECULES TO DISEASED TISSUE BY IMMUNE CELLS

INTRODUCTION:UCLA researchers in the Departments of Integrative Biology & Physiology and Pathology & Laboratory Medicine have developed a novel construct for targeting therapeutic biological molecules specifically to diseased tissue, using immune cells as a delivery system. BACKGROUND:Drug delivery is the process of administering a pharmaceutical...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nucleic Acids

2019-863 METHODS CONCERNING ONGOING TREATMENT FOR CANCER

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel biomarker detection method for circulating blood cell-free RNA. BACKGROUND: Approximately 39% of men and women will be diagnosed with cancer at some point during their lifetimes. Circulating tumor cell-free DNA (cfDNA) is being increasingly used...

Published: 7/19/2023 | Inventor(s): Matteo Pellegrini, Eri Srivatsan

Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Oncology

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Diagnostic Markers, Platforms > Drug Delivery > Nucleic Acids

2019-260 IN VITRO RECONSTITUTED ENVELOPED VIRUS-LIKE PARTICLES (EVLPS) FOR RNA GENE DELIVERY

INTRO SENTENCE:UCLA researchers in the Department of Chemistry & Biochemistry have developed novel enveloped virus-like particles for the delivery of cancer vaccines, viral vaccines, and chemically-modified mRNA. TITLE: In Vitro Reconstituted Enveloped Virus-Like Particles (EVLPs) For RNA Gene DeliveryBACKGROUND:Virus-like particles (VLPs)...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Platforms > Drug Delivery > Nucleic Acids

2017-224 SHARPR-MPRA (Systematic High-Resolution Activation and Repression Profiling with Reporter-Tiling Massively Parallel Reporter Assay)

SHARPR-MPRA (Systematic High-Resolution Activation And Repression Profiling With Reporter-Tiling Massively Parallel Reporter Assay)SUMMARYUCLA researchers in the Department of Biological Chemistry have developed a method to screen hundreds to thousands of genes to identify their regulatory functions.BACKGROUNDGenetic reporter assays are used to uncover...

Published: 9/20/2023 | Inventor(s): Jason Ernst, Manolis Kellis

Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Research Methods

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools, Platforms > Drug Delivery > Nucleic Acids, Platforms > Drug Delivery > Nucleic Acid Platform Systems

2018-437 SCALABLE LIPID BILAYER MICROFLUIDICS FOR HIGH-THROUGHPUT GENE EDITING

Scalable Lipid Bilayer Microfluidics for High-Throughput Gene EditingSUMMARYResearchers led by Paul Weiss from the Department of Chemistry and Pediatrics at UCLA have created a new microfluidic device for high-throughput gene editing of cells.BACKGROUNDGene editing has many potential applications, allowing for the modification of immune cells to target...

Published: 7/19/2023 | Inventor(s): Jason Belling, Paul Weiss, Steven Jonas, Joshua Jackman, Nam-Joon Cho

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, General Device Coatings, Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Nucleic Acids, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Medical Devices > Coatings, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery > Nucleic Acids

Improvement To Retroviral Vectors Containing The Human Ubiquitin C Promoter

SummaryUCLA researchers in the Department of Molecular Biology have developed a lentiviral vector, “pCCLc-roUBC”, containing the cellular promoter from the human ubiquitin C gene (UBC), to improve transgene expression in retroviral vectors.BackgroundGene delivery into human cells is a promising way to correct or protect against genetic alterations...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery > Nucleic Acids

Amphiphilic Derivatives Of Thioether Containing Block Copolypeptides

SummaryUCLA researchers in the Department of Bioengineering have developed a new method to generate amphiphilic block copolypeptides.BackgroundBlock copolymers with amphiphilic character can self-assemble into a variety of micellar structures, including spherical micelles, rodlike micelles, or vesicles. These structures have utility in drug delivery,...

Published: 7/19/2023 | Inventor(s): Timothy Deming, Jessica Kramer, April Rodriguez

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Drug Delivery, Nucleic Acids, Other Polymers

Category(s): Diagnostic Markers, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acids, Platforms > Drug Delivery > Other Polymers

2017-645 HUMANIZED ANTIBODIES TO THE EXTRACELLULAR DOMAINS OF HUMAN N-CADHERIN

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed humanized antibody therapies for invasive prostate and bladder cancers that express N-cadherin.BACKGROUNDProstate cancer is the second leading cause of cancer death among men in the United States (National Cancer Institute). Unfortunately, systemic therapies such...

Published: 3/8/2024 | Inventor(s): Anna Wu, Robert Reiter, Kirstin Zettlitz

Keywords(s): Antibodies, Antibody Delivery Platforms, Diagnostic Markers & Platforms, Drug Delivery, Gastroenterology & Digestive Disease, Life Science Research Tools, Nucleic Acids, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Therapeutics, Therapeutics > Gastroenterology, Platforms > Drug Delivery > Nucleic Acids