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Label-Free Optical Mapping for Large-Area Biomechanical Dynamics of Multicellular Systems (Case No. 2023-290)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel label-free optical mapping method for profiling real-time biomechanical dynamics over larger areas with high spatiotemporal resolution. Background: Mapping biomechanical dynamics often involves the use of various advanced technologies to measure...

Published: 12/20/2023 | Inventor(s): Pei Yu Chiou, Yen-Ju Lin

Keywords(s): bioimaging, Biomechanics, cell imaging, Confocal Microscopy, dye, Fluorescence Microscope, labeling, Microscopy, Microscopy And Imaging, resolution, traction force microscopy

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Cell Counting And Imaging, Medical Devices, Medical Devices > Medical Imaging, Platforms, Platforms > Diagnostic Platform Technologies

2022-258 Deep Learning-Enabled Detection and Classification of Bacterial Colonies Using a Thin Film Transistor (TFT) Image Sensor

Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed a thin-film transistor-based image sensor that can quantify and identify bacterial colony forming units (CFUs) with high accuracy using a deep-learning algorithm. Background: Bacterial infections are a leading cause of death every year in both developed...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Yuzhu Li, Tairan Liu

Keywords(s): Antibacterial, Artificial Neural Network, Bacteria, Holography, Machine Learning, Magnetic Resonance Imaging Carotid Artery Stenosis, Thin-Film Transistor, Transistor

Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Screening Libraries, Materials, Materials > Nanotechnology, Materials > Semiconducting Materials, Life Science Research Tools > Cell Counting And Imaging

2023-021 A Ferrobotic Swarm Technology for Accessible, Adaptable, and Automated Testing

Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed an automated, algorithm-driven nucleic acid amplification test (NAAT) method that is easy to manufacture, distribute, and yields accurate results with reduced demand of testing reagents. Background: Major epidemics over the last two decades have emerged...

Published: 8/8/2023 | Inventor(s): Dino Di Carlo, Sam Emaminejad, Haisong Lin, Wenzhuo Yu, Kiarash AmirMozafariSabet

Keywords(s): Algorithm, algorithm-based testing, automated testing, Automation, Cell Counting/Imaging, COVID-19, Ferrofluid, ferrorobotics, high throughput testing, Nanotechnology, nucleic acid amplification test (NAAT), Nucleic Acid Platform Systems, Nucleic Acids, polymerase chain reaction (PCR), pooling, Software & Algorithms, viral testing

Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Research Methods, Electrical > Electronics & Semiconductors, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies

2012-341 Quantum Dot Enabled Detection of Escherichia Coli using a Cell-Phone

Summary: UCLA researchers in the Department of Electrical Engineering have developed a platform that can detect E. coli using a cell phone. Background: Water and food-associated diseases still pose considerable public health threat even in highly industrialized parts of the world, causing significant amount of hospitalizations and deaths every year....

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Hongying Zhu

Keywords(s): Cell Counting/Imaging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Image Processing, Infectious Diseases, Photonics

Category(s): Software & Algorithms > Image Processing, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies, Therapeutics > Infectious Diseases, Optics & Photonics

Robot-On-A-Dish: Automating Cellular Sorting and Analysis via Robotic Motor-Driven Flow

Summary: UCLA researchers in the Department of Bioengineering have built a new cell sorting system that can handle and maintain linear flow control for a broad range of mesoscale particles in fluids. Background: The global market for drug discovery technologies was valued at $65.3 billion in 2019, and it is expected to grow at a CAGR of 9.6%....

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Reem Khojah

Keywords(s): Cell Counting/Imaging, Content Analysis, Diagnostic Markers & Platforms, Drug Discovery, Flow Cytometry, Flow Device, High-Throughput Screening, mesoscale, mesoscale particles, Robotic liquid handling

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Chemical, Chemical > Instrumentation & Analysis, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2021-313 METHODS OF ANALYZING NANOVIALS CONTAINING CELLS USING FLUORESCENCE ACTIVATED CELL SORTING

Summary: UCLA researchers in the Department of Bioengineering have developed a high throughput, single cell screening and sorting platform to facilitate single cell functional assays. Background: Biological assays are usually performed using microwell plates because of their ability to scale experiments and integrate with current lab automation...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo

Keywords(s): Assay, Biotechnology, Life Science Research Tools, Nanotechnology, Targets And Assays

Category(s): Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Materials > Functional Materials, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Materials > Nanotechnology

2021-355 Magnetically Activated Individual Cell Sorting Using Spin Orbit Torque

SUMMARY: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a magnetically activated cell sorting method with high throughput and low-cost operation. BACKGROUND: The use of cell sorting techniques has become indispensable for many applications in biology and biomedicine. Cell sorting is particularly important...

Published: 7/19/2023 | Inventor(s): Abdon Sepulveda, Victor Estrada, Ruoda Zheng, Yilian Wang

Keywords(s): Cancer Immunotherapy, Chemical, Diagnostic Markers & Platforms, High-Throughput Screening, Imaging, Magnetic Field, Materials, Nanomaterials, Nanotechnology, T Cell

Category(s): Life Science Research Tools > Microscopy And Imaging, Materials > Nanotechnology, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging, Medical Devices > Medical Imaging

Biocompatible, Degradable Hollow Shell Particles for High-Throughput Screening and Sorting of Cells (Case No. 2021-026)

Summary: UCLA researchers in the Department of Bioengineering have developed a microfluidic technique that can encapsulate specific cells and separate them with fluorescence cell sorters. Background: The interest in cell-derived byproducts such as recombinant therapeutic proteins and antibody therapy has increased in the past years. Typically,...

Published: 7/31/2023 | Inventor(s): Dino Di Carlo, Mark Van Zee, Joseph de Rutte, Sohyung Lee

Keywords(s): Assay, Bioassay, Cell Growth, Fluorescence, Fluorescent Labelling, High-Content Screening, High-Throughput Screening, Nanotechnology, Screening Libraries

Category(s): Life Science Research Tools, Life Science Research Tools > Screening Libraries, Life Science Research Tools > Cell Lines, Life Science Research Tools > Cell Counting And Imaging, Materials > Nanotechnology

2018-718 Transverse Sheet Illumination Microscopy (TranSIM)

SUMMARYUCLA researchers in the Department of Physics and Astronomy and at the California NanoSystems Institute have developed a highly customizable single objective microscopy technique which exhibits micron resolution in three dimensions, near millisecond temporal resolution (5 ms) and gentle illumination, allowing for the simultaneous imaging of multiple...

Published: 7/19/2023 | Inventor(s): Katsushi Arisaka, Javier Carmona Jr., Laurent Bentolila, Blake Madruga

Keywords(s):

Category(s): Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Animal Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Cell Counting And Imaging, Optics & Photonics

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