Search Results - ali+khademhosseini

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2022-086: NANOTECHNOLOGY FOR CHEMOTHERAPY DRUG CAPTURE

SUMMARY: UCLA researchers in the Departments of Chemical Engineering and Bioengineering and Radiological Sciences have developed a cellulose-based nanomaterial for removing excess chemotherapy drugs from the body to reduce the side-effects of cancer therapy. BACKGROUND: Cancer is one of the leading causes of death worldwide, affecting millions of...

Published: 11/15/2024 | Inventor(s): Amir Sheikhi, Ali Khademhosseini

Keywords(s):

Category(s): Materials > Nanotechnology, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

2021-030 BIODEGRADABLE MICRONEEDLE PATCH FOR TRANSDERMAL GENE DELIVERY

UCLA researchers in the Department of Bioengineering have developed a novel microneedle patch that effectively delivers nucleic acids across the skin for use as a delivery platform for gene therapies.BACKGROUNDGene therapies work by delivering designed corrective nucleic acid sequences to cells expressing mutant disease-causing forms of genes. For gene...

Published: 9/5/2023 | Inventor(s): Ali Khademhosseini, Wujin Sun

Keywords(s): Gene Therapy

Category(s): Therapeutics > Gene Therapy And Editing

2021-046 SOFT BIOSENSORS BASED ON BIODEGRADABLE GELATIN METHACRYLOYL (GELMA)

UCLA researchers in the department of Bioengineering have developed a soft biodegradable hydrogel that is capable of functioning in biocompatible biosensors.BACKGROUNDBiosensors are physical devices that combine a physiochemical detector with a biological component. The use of biosensors has revolutionized a number of industries including the medical...

Published: 9/5/2023 | Inventor(s): Ali Khademhosseini, Shiming Zhang, Zhikang Li

Keywords(s): Biosensor

Category(s): Medical Devices

2021-100 HIGH-THROUGHPUT DISEASE BIOMARKER SCREENING WITH HIGH-TRANSCONDUCTANCE ORGANIC ELECTROCHEMICAL TRANSISTOR ARRAYS

Researchers in UCLA’s Department of Bioengineering have developed a transistor-based biosensor for high-throughput disease biomarker screening applications: this minimally invasive sensor features high sensitivity and robustness to competing biomarkers, potentially enabling a next-generation mobile point of care (POC) device.BACKGROUNDMolecular...

Published: 7/19/2023 | Inventor(s): Shiming Zhang, Ali Khademhosseini

Keywords(s): Biomarker

Category(s): Medical Devices

2019-866 METHODS FOR IMPROVING THE TISSUE SEALING PROPERTIES OF HYDROGELS AND THE USE THEREOF

UCLA researchers in the Department of Bioengineering have optimized the sealing properties of naturally derived biopolymers, without altering their other attractive abilities like biodegradation.BACKGROUND: A significant number of emergency room cases consist of wound-related injuries. While the body is particularly adapted to treat various types of...

Published: 11/15/2024 | Inventor(s): Ali Khademhosseini, Nasim Annabi, Amir Sheikhi

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Structures

Category(s): Chemical > Industrial & Bulk Chemicals

Wound Closure Devices 2019-816, 2020-867

BACKGROUNDWound closure devices for internal luminal repair have historically been limited to staples (nondegradable, commonly titanium), sutures, and/or adhesives. The urinary tract in particular is an area in which sutured repairs with bioabsorbable sutures remain the standard closure mechanism due to the risk of stones and UTIs with staples and the...

Published: 7/19/2023 | Inventor(s): Renea Sturm, George Aninwene, Peyton Tebon, Mohammad Ali Darabi, Ali Khademhosseini

Keywords(s):

Category(s): Medical Devices > Surgical Tools

2020-443 A PATCH OF DETACHABLE HYBRID MICRONEEDLE DEPOT (D-HMND) FOR LOCALIZED DELIVERY OF MESENCHYMAL STEM CELLS IN REGENERATION THERAPY

UCLA researchers in the Department of Bioengineering have developed a novel detachable hybrid microneedle depot (d-HMND) for the targeted delivery of mesenchymal stem cells. BACKGROUND: Stem cell biology has been widely applied to the treatment of tissue damage, due to the ability of stem cells to form, repair, and maintain tissues and organs after...

Published: 7/19/2023 | Inventor(s): Ali Khademhosseini

Keywords(s): iPS/stem cells, Life Science Research Tools, Stem Cells / Regenerative Medicine, Therapeutics & Vaccines

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2020-407 TOUGH TISSUE SEALANTS AND THE USE THEREOF

Researchers in the UCLA Departments of Chemical Engineering, Bioengineering, and Radiological Sciences and the Pennsylvania State University Department of Chemical Engineering have developed a novel tissue adhesive hydrogel material for use in sealing wounds in stretchable tissues. BACKGROUND:Surgical sealants may be used as an alternative to sutures,...

Published: 11/15/2024 | Inventor(s): Amir Sheikhi, Maryam Tavafoghi, Ali Khademhosseini

Keywords(s): Medical Devices and Materials, Other, Surgical Tools

Category(s): Medical Devices > Surgical Tools

2018-709 AN INTEGRATED ORGAN-ON-A-CHIP PLATFORM FOR AUTOMATED CARDIOTOXICITY SCREENING OF CHEMOTHERAPEUTIC DRUGS

INTRODUCTION: UCLA researchers in the Departments of Bioengineering and Cardiology have developed a novel organ-on-a-chip platform using patient specific iPSC-derived cardiomyocytes and hepatocytes, for the general toxicity screening of drugs. BACKGROUND:Clinical trials are required to evaluate the effect of drugs on human patients, following preclinical...

Published: 7/19/2023 | Inventor(s): Ali Khademhosseini, Reza Ardehali

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Microfluidics And Mem's

Category(s): Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2017-109 High-Throughput Microfluidic Gene-Editing Via Cell Deformability within Microchannels

High-Throughput Microfluidic Gene-Editing via Cell Deformability within MicrochannelsSUMMARYUCLA researchers in the Departments of Pediatrics and Chemistry & Biochemistry have developed a microfluidic device for delivery of biomolecules into living cells using mechanical deformation, without the fouling issues in current systems.BACKGROUNDGene therapy...

Published: 7/19/2023 | Inventor(s): Steven Jonas, Paul Weiss, Ali Khademhosseini, Joanna Aizenberg, Xu Hou

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Microfluidics And Mem's, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing

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