Search Results - therapeutics+%3e+immunology+and+immunotherapy

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Nanobody-Based Chimeric Antigen Receptors Targeting Prostate-Specific Membrane Antigen (PSMA) in Prostate Cancer (UCLA Case No. 2025-125)

UCLA researchers from the Department of Medicine have developed and optimized nanobody-based chimeric antigen receptors that effectively target prostate cancer cells in in vitro and in vivo prostate cancer models. BACKGROUND: Prostate cancer is the second leading cause of cancer-related death in American men. Prostate-specific membrane antigen (PSMA),...

Published: 9/30/2026 | Inventor(s): John Lee

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

A Chimeric Antigen Receptor Design with T Cell Receptor-Like Signaling (UCLA Case No. 2026-226)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have designed a novel chimeric antigen receptor (CAR) construct with T-cell receptor-like signaling that has improved expression and similar or superior viral suppression compared to existing CAR constructs. BACKGROUND: Chimeric antigen receptor (CAR) gene therapy...

Published: 9/11/2026 | Inventor(s): Otto Yang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology

Harnessing Embryonic Factors to Modulate the Tumor Microenvironment and Bypass Therapeutic Resistance (UCLA Case No. 2026-099, Kitai Kim)

Contact UCLA Technology Development Group (TDG) for more information on this technology.

Published: 9/24/2026 | Inventor(s): Kitai Kim

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Active Electromagnetic Interference Suppression for Magnetic Resonance Imaging-Guided Interventions (Case No. 2026-217)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a software-based active electromagnetic interference suppression solution for real-time MRI-guided interventions. Background: Microwave ablation (MWA) has emerged as the preferred thermal ablation modality for treating non-surgical patients with primary and metastatic...

Published: 7/23/2026 | Inventor(s): Holden Wu, Qing Dai

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Lab Equipment, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Mechanical, Mechanical > Instrumentation, Mechanical > Sensors, Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Electrical > Instrumentation, Electrical > Imaging

Enhanced Therapeutic Effect of Armored CAR-T Cells for the Treatment of Glioblastoma (UCLA Case No. 2024-066)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have engineered chimeric antigen receptor (CAR)-T cells that co-express defined immunostimulatory cytokines to enhance therapeutic efficiency against glioblastoma (GBM). BACKGROUND: Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor...

Published: 9/26/2026 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > CNS and Neurology

Microbial Regulation of Immune Tolerance and Risk for Cancer (UCLA Case No. 2026-153)

UCLA researchers in the Department of Integrative Biology and Physiology have identified a microbiome-driven signaling pathway that increases serotonin production and colorectal cancer (CRC) risk which may serve as a valuable therapeutic target for CRC. BACKGROUND: The gut microbiome plays a central role in regulating host physiology through interactions...

Published: 7/20/2026 | Inventor(s): Elaine Hsiao, Lewis Yu

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Gastroenterology, Therapeutics > Immunology And Immunotherapy, Diagnostic Markers > Cancer

Partial Transcription Factor Reprogramming to Rejuvenate Exhausted Tumor-Specific T Cells into Stem-Like Memory T Cells (UCLA Case No. 2024-240)

UCLA researchers from the Department of Surgery have developed a novel approach to partially reprogram exhausted tumor-infiltrating T cells into stem-like memory T cells capable of durable tumor elimination. BACKGROUND: Adoptive cell therapies, such as tumor-infiltrating lymphocyte (TIL) therapy involve isolating T cells from a patient’s tumor,...

Published: 7/20/2026 | Inventor(s): Tyler McCaw, Joseph Crompton

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Life Science Research Tools > Research Methods

Compositions and Methods to Modulate MAVS-Mediated Immunity (UCLA Case No. 2026-096)

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed methods to target TOM70, a mitochondrial outer membrane protein, to selectively modulate innate immune signaling and control pathological or protective immune responses across a range of clinical conditions. BACKGROUND: Innate immune detection of viral...

Published: 7/20/2026 | Inventor(s): Lena Pernas

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Autoimmune, Therapeutics > Vaccines

Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)

UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. BACKGROUND: Adoptive cell therapy has vastly expanded in the past years...

Published: 8/11/2026 | Inventor(s): Gay Crooks, Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases

Enhancing T Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)

UCLA researchers from the Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. BACKGROUND: T cell immunotherapy is a widely utilized treatment that leverages a patient’s own T cells to combat diseases such as cancer or viral infections. Adoptive...

Published: 8/11/2026 | Inventor(s): Gay Crooks, Christopher Seet

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

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