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A Wearable On-Eyelid Sensor Network for Vestibular-Ocular Reflex Assessment (Case No. 2023-166)

Summary: UCLA researchers in the Department of Bioengineering have developed an ultra-thin, self-powered, waterproof, biocompatible, and sensitive on-eyelid sensor network for wireless eye movement detection, enhancing vestibular diagnostics. Background: The human balance system relies on the interaction of the vestibular system with the visual and...

Published: 4/19/2024 | Inventor(s): Jun Chen, Jing Xu

Keywords(s): diseases of the eye, eye motion, eye movement disorders, eye tracking, gaze fixation, magnetoelastic effect, magnetoelastic sensor, on-eyelid sensor, peripheral vestibular disorders, vestibular pathology assessment, Vestibular-Ocular Reflex (VOR)

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics, Electrical, Electrical > Signal Processing, Electrical > Sensors

Field-Effect Transistor Biosensors Integrated With Porous Media (Case No. 2023-093)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering in collaboration with the University of Chicago have developed a new diagnostic biosensor by combining field-effect transistors with porous media. Background: Point-of-care (POC) and self-testing tools rely on the real-time monitoring of biomarkers in bodily fluids....

Published: 4/1/2024 | Inventor(s): Aydogan Ozcan, Hyou-Arm Joung, Hyun-June Jang, Junhong Chen

Keywords(s): Biomarker, biomarkers, Biomaterial, Biosensor, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Electrical, Electrical Engineering, electrically-mediated sensing, electrochemical sensors, enzyme functionalization, Medical diagnostics, multiplexed analysis, Point Of Care, point-of-care, porous media, sample matrix effects, transistors

Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms, Platforms > Diagnostic Platform Technologies

Novel Anti-mesothelin CAR for Use in Engineered Cell Therapies (UCLA Case No. 2023-281)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a nanobody-based CAR T cell platform with increased stability and cross-immunogenicity between human and mouse antigens. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered T cells to target and clear cancer cells....

Published: 3/6/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer, CAR-T cell platform, CAR-T cell therapy, cell engineering, Immunotherapy, Mesothelin, nanobody, Nanoparticle

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Synaptic Circuits Made From Transistors and Memory Capacitors (UCLA Case No. 2023-092)

Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel circuit architecture that emulates neural synapses for concurrent parallel computing. Background: Almost all modern computer chips consist of computing and learning processes that are implemented sequentially. To improve computing power,...

Published: 12/19/2023 | Inventor(s): Yong Chen, Zixuan Rong

Keywords(s): Application-Specific Integrated Circuit, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, Artificial Neural Network Artificial Neuron, artificial-intelligent materials, autonomous control, computational efficiency, edge computing, Electronics & Semiconductors, Energy Efficiency, energy management, Integrated Circuit, Medical artificial intelligence (AI), Neuromorphic circuits, parallel processing, parallel signal processing, processor design, Semiconductor, semiconductor chip foundries, Semiconductor Device, Semiconductors, synaptic resistor (synstor)

Category(s): Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Materials, Materials > Semiconducting Materials, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning

Ion-Solvent-Polymer Interactions for Preparing Polymer Networks and Composites of Tunable Structures and Properties (UCLA Case No. 2023-147)

Summary: Researchers in UCLA's Department of Materials Science and Engineering have developed a solution-based synthesis platform capable of generating micro and nanostructured gels, polymers, and composites with simultaneously improved safety, mechanical and ionic conductivity/transport properties. Background: Pore structure engineering holds...

Published: 11/20/2023 | Inventor(s): Ximin He

Keywords(s):

Category(s): Chemical, Chemical > Polymers, Chemical > Synthesis, Energy & Environment, Energy & Environment > Energy Storage, Materials, Materials > Fabrication Technologies, Materials > Functional Materials, Materials > Composite Materials

A Process for Identifying Health Modifying Interventions Through Epigenetic Prediction (Case No. 2023-107)

Summary: UCLA researchers in the Department of Neurology have developed a novel method that leverages epigenetic markers to identify recommended and necessary health interventions. Background: Disease risk prediction and intervention involves identifying individuals or populations with a higher likelihood of developing a particular condition based...

Published: 3/22/2024 | Inventor(s): Noah Zaitlen, Eran Halperin, Elior Rahmani, Michael Thompson, Zeyuan (Johnson) Chen

Keywords(s): Clinical decision support system, clinical outcome, Clinical Trial, disease outcome, Epigenetics, health risk assessment, outcome probability, patient outcome, prognostic, Public Health, public health monitoring, Risk Assessment, risk reduction, risk score, Simulation & Modeling, statistical modeling, treatment efficacy

Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health, Software & Algorithms > Statistical Models, Medical Devices, Medical Devices > Monitoring And Recording Systems

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an AI-guided, smart histopathological image viewer to aid clinicians in the identification of regions of interest. Background: Digital pathology has transformed traditional glass histology slides into high-resolution digital slide images, priming the...

Published: 10/25/2023 | Inventor(s): Xiang Chen, Hongyan Gu, Mohammad Haeri, Shino Magaki

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Neural Network, Clinical decision support system, Computer-Aided Diagnosis, Digital Health, Digital Pathology, Histopathological image analysis, Histopathology, histopathology images, Human-AI collaboration, Human-AI interaction, Medical artificial intelligence (AI), Medical Imaging, pathology image analysis

Category(s): Electrical, Electrical > Imaging, Medical Devices, Medical Devices > Medical Imaging, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel software tool that leverages artificial intelligence to assist with a user’s expressive writing process. Background: With the recent rise in mental health diagnoses and awareness, there is a higher demand for mental health services which...

Published: 12/20/2023 | Inventor(s): Xiang Chen, Ruolin Wang

Keywords(s): active learning, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, clinical mental health, design software, expressive writing, human-centered computing, intervention, Machine Learning, Mental health, Software, Software & Algorithms, Software Development Tools, talk therapy, therapy

Category(s): Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning

Interactive Reporting of Histopathological Image Analysis Performed by Artificial Intelligence (UCLA Case No. 2023-090)

Summary: Researchers from UCLA's Departments of Electrical and Computer Engineering and Pathology and Laboratory Medicine, along with a researcher from KUMC's Department of Pathology and Laboratory Medicine, have developed an innovative workflow for pathology, integrating artificial intelligence (AI) diagnostics with interactive reporting. Background: The...

Published: 11/28/2023 | Inventor(s): Xiang Chen, Hongyan Gu, Mohammad Haeri, Shino Magaki

Keywords(s): 2. Medical science computing, algorithmic cancer detection, Cancer, cancer detection, Computer Aided Learning, Digital Health, Digital Holography, Digital immunohistology, Digital Pathology, Histology, Histopathological image analysis, Histopathology, Immunohistochemistry

Category(s): Medical Devices, Medical Devices > Medical Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing

2022-190 Pharmacological Modulation of Chimeric Antigen Receptor (CAR)-T Cell Signaling Pathways to Improve Tumor-Killing Efficacy

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel chimeric antigen receptor (CAR)-T cell manufacturing process to prevent premature CAR-T cell dysfunction and enhance CAR-T cell durability and potency. BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy is an emerging pillar...

Published: 8/20/2023 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

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