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Core-Shell Hydrogel Particles With Tunable Porosity for Digital Nucleic Acid Assays (Case No. 2023-058)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel method to perform ultra-high sensitivity, low-cost nucleic acid amplification assays utilizing porous microdroplets. Background: Nucleic acid concentration measurement is essential in biological research and diagnostics. The 2020 pandemic underscored the importance...

Published: 8/30/2023 | Inventor(s): Dino Di Carlo, Michael Thomas Alesse Bogumil

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Flow Cytometry, Medical diagnostics

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Chemical > Emulsions, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

Robot-On-A-Dish: Automating Cellular Sorting and Analysis via Robotic Motor-Driven Flow

Summary: UCLA researchers in the Department of Bioengineering have built a new cell sorting system that can handle and maintain linear flow control for a broad range of mesoscale particles in fluids. Background: The global market for drug discovery technologies was valued at $65.3 billion in 2019, and it is expected to grow at a CAGR of 9.6%....

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Reem Khojah

Keywords(s): Cell Counting/Imaging, Content Analysis, Diagnostic Markers & Platforms, Drug Discovery, Flow Cytometry, Flow Device, High-Throughput Screening, mesoscale, mesoscale particles, Robotic liquid handling

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Chemical, Chemical > Instrumentation & Analysis, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2021-118 RAPID RESPONSE MICROFLUIDIC CHIP FOR SCREENING THROMBOTIC RISK FROM S-SPIKE PROTEIN IN THE CONTEXT OF SARS-COV-2

SUMMARY: UCLA researchers in the Department of Medicine and Bioengineering have developed a novel microfluidic approach to study SARS-CoV-2 infection entry into blood cells of COVID-19 patients as a research tool to better understand the mechanisms that lead to blood clot formation. BACKGROUND: The World Health Organization estimates that there are...

Published: 9/5/2023 | Inventor(s): Tzung Hsiai, Angela Lai, Sandro Satta

Keywords(s):

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2020-908 LASER ACTUATED SUPERCRITICAL INJECTOR (LASI)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering developed a platform that applies high-speed fluidic jet injection of biomolecules into biological samples with the use of laser actuated supercritical injector (LASI). Background: Intracellular delivery of various biomolecules has been of great importance in biomedical...

Published: 7/19/2023 | Inventor(s): Pei Yu Chiou

Keywords(s):

Category(s): Life Science Research Tools > Microfluidics And Mems, Platforms > Drug Delivery, Optics & Photonics, Materials > Nanotechnology

2020-887 A Programmable Epidermal Microfluidic Valving System for Wearable Biofluid Management and Contextual Biomarker Analysis

SUMMARYResearchers in the UCLA Electrical and Computer Engineering Department have devised a programmable epidermal microfluid valving system for high frequency, real-time biofluid sampling, routing, and compartmentalization in wearable bioanalytical platforms.BACKGROUNDWearable biomarker sensing technologies allow for the frequent, longitudinal, and...

Published: 7/19/2023 | Inventor(s): Sam Emaminejad, Haisong Lin, Jiawei Tan

Keywords(s):

Category(s): Electrical > Electronics & Semiconductors, Electrical > Sensors, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies

2019-879 An Electronically-Controlled Digital Ferrofluidic Architecture for Scalable and Addressable Bioanalytical Operations

SUMMARYUCLA researchers in the Department of Electrical and Computer Engineering have developed a contactless digital ferrofluidic approach for small-volume droplet generation, manipulation and transport. BACKGROUND Automated microfluidic technologies can perform autonomous, accurate, and consistent fluidic operations. Current automated systems have...

Published: 7/19/2023 | Inventor(s): Sam Emaminejad, Dino Di Carlo

Keywords(s):

Category(s): Materials > Nanotechnology, Life Science Research Tools > Microfluidics And Mems, Materials > Fabrication Technologies, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nanoparticles, Chemical > Industrial & Bulk Chemicals

Nanoemulsion Technologies

Mason Group Website: http://www.chem.ucla.edu/dept/Faculty/Mason/BACKGROUNDNanoemulsions are oil-in-water (or vice versa) suspensions of nanoscale droplets that range in size from 15 to 100 nm and have a variety of applications including drug delivery, agriculture, personal care and food products. Nanoemulsions have many advantages over traditional...

Published: 7/19/2023 | Inventor(s): Thomas Mason

Keywords(s):

Category(s): Chemical > Instrumentation & Analysis, Chemical, Chemical > Emulsions, Chemical > Synthesis, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles, Chemical > Chemical Processing & Manufacturing, Materials > Nanotechnology

2011-819 No-Assembly Devices for Microfluidics Inside a Cavity

Summary UCLA researchers have developed a method to fabricate electrowetting microfluidic devices without assembly of their subcomponents. Background Current microfluidic devices having a cavity configuration with multiple electrodes must have their components separately fabricated and subsequently assembled (e.g., bonded, clamped) in order to form...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Microfluidics And Mems

2007-477 Cell Separation Device using High Electromagnetic Gradients through a Particle-based Microfluidic Approach

Summary A new fabrication method for a microfluidic cell separation device has been developed by UCLA investigators. The proposed design exerts significantly more magnetic force than conventional setups, while realizing low cost of production. Background Organizing and separating cells is a fundamental function in the research of biochemical systems....

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Microfluidics And Mems

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