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Core-Shell Hydrogel Particles With Tunable Porosity for Digital Nucleic Acid Assays (Case No. 2023-058)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel method to perform ultra-high sensitivity, low-cost nucleic acid amplification assays utilizing porous microdroplets. Background: Nucleic acid concentration measurement is essential in biological research and diagnostics. The 2020 pandemic underscored the importance...
Published: 8/30/2023
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Inventor(s):
Dino Di Carlo
,
Michael Thomas Alesse Bogumil
Keywords(s):
Diagnostic Markers & Platforms
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Diagnostic Test
,
Flow Cytometry
,
Medical diagnostics
Category(s):
Diagnostic Markers > Cancer
,
Diagnostic Markers > Targets And Assays
,
Chemical > Emulsions
,
Life Science Research Tools > Microfluidics And Mems
,
Life Science Research Tools > Research Methods
,
Platforms > Diagnostic Platform Technologies
2023-021 A Ferrobotic Swarm Technology for Accessible, Adaptable, and Automated Testing
Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed an automated, algorithm-driven nucleic acid amplification test (NAAT) method that is easy to manufacture, distribute, and yields accurate results with reduced demand of testing reagents. Background: Major epidemics over the last two decades have emerged...
Published: 8/8/2023
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Inventor(s):
Dino Di Carlo
,
Sam Emaminejad
,
Haisong Lin
,
Wenzhuo Yu
,
Kiarash AmirMozafariSabet
Keywords(s):
Algorithm
,
algorithm-based testing
,
automated testing
,
Automation
,
Cell Counting/Imaging
,
COVID-19
,
Ferrofluid
,
ferrorobotics
,
high throughput testing
,
Nanotechnology
,
nucleic acid amplification test (NAAT)
,
Nucleic Acid Platform Systems
,
Nucleic Acids
,
polymerase chain reaction (PCR)
,
pooling
,
Software & Algorithms
,
viral testing
Category(s):
Software & Algorithms
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Electrical > Electronics & Semiconductors
,
Diagnostic Markers
,
Life Science Research Tools > Cell Counting And Imaging
,
Platforms > Diagnostic Platform Technologies
Robot-On-A-Dish: Automating Cellular Sorting and Analysis via Robotic Motor-Driven Flow
Summary: UCLA researchers in the Department of Bioengineering have built a new cell sorting system that can handle and maintain linear flow control for a broad range of mesoscale particles in fluids. Background: The global market for drug discovery technologies was valued at $65.3 billion in 2019, and it is expected to grow at a CAGR of 9.6%....
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Reem Khojah
Keywords(s):
Cell Counting/Imaging
,
Content Analysis
,
Diagnostic Markers & Platforms
,
Drug Discovery
,
Flow Cytometry
,
Flow Device
,
High-Throughput Screening
,
mesoscale
,
mesoscale particles
,
Robotic liquid handling
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Chemical
,
Chemical > Instrumentation & Analysis
,
Life Science Research Tools > Lab Equipment
,
Life Science Research Tools > Cell Counting And Imaging
,
Life Science Research Tools > Microfluidics And Mems
Cellphone-Based Micro-Plate Reader for Point-Of-Care ELISA Testing & High-Throughput and Automated Diagnosis of Antimicrobial Resistance
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a cost-effective cellphone-based micro-plate reader to rapidly perform antimicrobial susceptibility testing (AST) with >99% accuracy. Background: Immunoassays are biochemical tests that are conducted to measure the presence and concentration of...
Published: 7/19/2023
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Inventor(s):
Aydogan Ozcan
,
Dino Di Carlo
,
Steve Feng
,
Bingen Cortazar Unzaga
,
Brandon Berg
,
Haydar Ozkan
,
Omai Garner
,
Kuochao Tseng
Keywords(s):
Antibacterial
,
Antibiotic Resistance
,
Antibody
,
Artificial Intelligence
,
Bacteria
,
Drug Resistance
,
ELISA
,
High-Throughput Screening
,
Immunoassay
,
Nanotechnology
,
Optics
,
Photonics
,
Point Of Care
,
Smartphone
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Antibodies
,
Diagnostic Markers
,
Optics & Photonics
,
Software & Algorithms > Artificial Intelligence & Machine Learning
2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME
SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Chueh-Yu Wu
Keywords(s):
Cell Counting/Imaging
,
Cytometry
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Flow Cytometry
,
Life Science Research Tools
,
Microfluidics
,
Microfluidics And Mem's
,
Targets And Assays
Category(s):
Life Science Research Tools > Research Methods
,
Diagnostic Markers > Targets And Assays
,
Life Science Research Tools > Cell Counting And Imaging
,
Life Science Research Tools > Microfluidics And Mems
,
Platforms > Diagnostic Platform Technologies
2021-313 METHODS OF ANALYZING NANOVIALS CONTAINING CELLS USING FLUORESCENCE ACTIVATED CELL SORTING
Summary: UCLA researchers in the Department of Bioengineering have developed a high throughput, single cell screening and sorting platform to facilitate single cell functional assays. Background: Biological assays are usually performed using microwell plates because of their ability to scale experiments and integrate with current lab automation...
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Joseph de Rutte
,
Robert Dimatteo
Keywords(s):
Assay
,
Biotechnology
,
Life Science Research Tools
,
Nanotechnology
,
Targets And Assays
Category(s):
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Research Methods
,
Materials > Functional Materials
,
Diagnostic Markers > Targets And Assays
,
Life Science Research Tools > Cell Counting And Imaging
,
Materials > Nanotechnology
2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS
Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Joseph de Rutte
,
Robert Dimatteo
,
Maani Archang
,
Robert Damoiseaux
,
Doyeon Koo
Keywords(s):
Antibody
,
B Cell
,
Bioassay
,
Cell Counting/Imaging
,
Cellular Differentiation
,
Cytometry
,
Flow Cytometry
,
Fluorescence
,
Hybridoma Technology
,
Secretory Component
,
T Cell
,
Targets And Assays
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Antibodies
,
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Research Methods
,
Life Science Research Tools > Other Reagents
,
Diagnostic Markers
,
Diagnostic Markers > Targets And Assays
,
Platforms > Diagnostic Platform Technologies
Biocompatible, Degradable Hollow Shell Particles for High-Throughput Screening and Sorting of Cells (Case No. 2021-026)
Summary: UCLA researchers in the Department of Bioengineering have developed a microfluidic technique that can encapsulate specific cells and separate them with fluorescence cell sorters. Background: The interest in cell-derived byproducts such as recombinant therapeutic proteins and antibody therapy has increased in the past years. Typically,...
Published: 7/31/2023
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Inventor(s):
Dino Di Carlo
,
Mark Van Zee
,
Joseph de Rutte
,
Sohyung Lee
Keywords(s):
Assay
,
Bioassay
,
Cell Growth
,
Fluorescence
,
Fluorescent Labelling
,
High-Content Screening
,
High-Throughput Screening
,
Nanotechnology
,
Screening Libraries
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Screening Libraries
,
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Cell Counting And Imaging
,
Materials > Nanotechnology
2021-002 System and Methods for Amplified Detection of Molecules on Microparticles
SUMMARYUCLA researchers in the Department of Bioengineering have developed a system to build immunocomplexes, generate and accumulate amplified signals, and perform the signal readout of a digital ELISA using standard benchtop instruments and techniques.BACKGROUNDDigital ELISA allows for the detection and measurement of protein biomarkers at a single-molecule...
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Yilian Wang
,
Vishwesh Nilesh Shah
Keywords(s):
Category(s):
Life Science Research Tools > Research Methods
,
Life Science Research Tools > Lab Equipment
,
Life Science Research Tools > Antibodies
,
Diagnostic Markers > Immunology
,
Diagnostic Markers > Targets And Assays
,
Platforms > Diagnostic Platform Technologies
2018-846 Nanoplasmonic Biosensing Platform Using Single Nanoparticle Colorimetry
SUMMARYUCLA researchers in the Department of Bioengineering have developed a plasmonic swarm biosensing platform for molecular detection based on single nanoparticle imaging to improve quantitative accuracy with simple instrumentation. BACKGROUNDLocalized surface plasmon resonance (LSPR) is a near-field phenomenon that is used to detect biomolecules....
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Mengxing Ouyang
Keywords(s):
Category(s):
Life Science Research Tools > Research Methods
,
Platforms > Diagnostic Platform Technologies
,
Materials > Nanotechnology
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