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Synthetic Viscoelastic Activating Cells (SynVACs) for T cell engineering (UCLA Case No. 2023-190)
UCLA researchers in the Department of Bioengineering have developed a novel microfluidic device that produces synthetic viscoelastic cells for efficacious therapeutic T cell activation. BACKGROUND: T cell-based therapies, such as the chimeric antigen receptor (CAR) T cell therapy, represents a significant advancement in cancer treatment, particularly...
Published: 3/6/2024
|
Inventor(s):
Zeyang Liu
,
Song Li
,
Lili Yang
,
Yan-Ruide Li
Keywords(s):
CAR-T cell therapy
,
Synthetic antigen presenting cells (SynVACs)
,
T Cell
,
T cell based therapy
,
T-cell activation
,
T-cell engineering
,
t-cells
Category(s):
Therapeutics > Oncology
Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)
UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....
Published: 2/26/2024
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Inventor(s):
Mohammad Hasani-Sadrabadi
,
Song Li
,
Manish Butte
Keywords(s):
aAPCs
,
Aging
,
artificial presenting cells
,
cytokines
,
elderly
,
immunosenescence
,
microparticles
,
platform technology
,
SARS-CoV-2
,
T memory stem cells
,
TMSCs
,
Vaccines
Category(s):
Therapeutics > Infectious Diseases
,
Therapeutics > Oncology
2021-003 A Chemical Cocktail Driving Expansion of Myogenic Stem Cells
SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel chemical cocktail for enhancing myogenic stem cell expansion both in vitro and in situ that could lead to more affordable and faster development of stem cell-based therapies and chemical delivery technologies for muscle regeneration. BACKGROUND: Skeletal muscle tissue...
Published: 8/25/2023
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Inventor(s):
Song Li
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Musculoskeletal Disease
2023-021 A Ferrobotic Swarm Technology for Accessible, Adaptable, and Automated Testing
Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed an automated, algorithm-driven nucleic acid amplification test (NAAT) method that is easy to manufacture, distribute, and yields accurate results with reduced demand of testing reagents. Background: Major epidemics over the last two decades have emerged...
Published: 8/8/2023
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Inventor(s):
Dino Di Carlo
,
Sam Emaminejad
,
Haisong Lin
,
Wenzhuo Yu
,
Kiarash AmirMozafariSabet
Keywords(s):
Algorithm
,
algorithm-based testing
,
automated testing
,
Automation
,
Cell Counting/Imaging
,
COVID-19
,
Ferrofluid
,
ferrorobotics
,
high throughput testing
,
Nanotechnology
,
nucleic acid amplification test (NAAT)
,
Nucleic Acid Platform Systems
,
Nucleic Acids
,
polymerase chain reaction (PCR)
,
pooling
,
Software & Algorithms
,
viral testing
Category(s):
Software & Algorithms
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Electrical > Electronics & Semiconductors
,
Diagnostic Markers
,
Life Science Research Tools > Cell Counting And Imaging
,
Platforms > Diagnostic Platform Technologies
Immunoactive Microparticles and Uses Thereof (UCLA Case No. 2020-200)
SUMMARY: UCLA Researchers from the division of Immunology in the David Geffen School of Medicine have developed an improved method of stimulating anti-tumor T-cells for use in cancer immunotherapy. BACKGROUND: Cancer immunotherapy, a therapeutic strategy whereby a patient’s own immune system is reequipped to attack cancer cells, promises more...
Published: 4/9/2024
|
Inventor(s):
Manish Butte
,
Mohammad Hasani-Sadrabadi
,
Fatemeh Sadat Majedi
,
Song Li
Keywords(s):
Category(s):
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Materials > Nanotechnology
Novel Vaginal Drug Delivery Device (UCLA Case No. 2020-444)
Summary: UCLA researchers in the Departments of Biomedical Engineering and Medicine have developed vaginal drug delivery devices for the administration of contraceptives and antibiotics. Background: Globally, 1.9 billion women of reproductive age (15-49 years) use contraceptives. An additional 190 million women would use phrophylactics/contraceptives...
Published: 2/29/2024
|
Inventor(s):
Leena Nathan
,
Song Li
,
Tamara Grisales
,
Mohammad Hasani-Sadrabadi
Keywords(s):
Category(s):
Platforms > Drug Delivery
,
Platforms > Drug Delivery > Antibody Delivery Platforms
,
Platforms > Drug Delivery > Other Polymers
2021-052 BOOST CARDIAC REPROGRAMMING BY MODULATING IMMUNE CELLS AND MICROENVIRONMENT
SUMMARYResearchers from the Department of Bioengineering at UCLA have identified key players in in both preventing and boosting cardiac reprogramming. This innovation can be used for in vivo human cardiac reprogramming to provide a novel approach for cardiac regeneration in the clinic and other fields of regenerative medicine. BACKGROUNDIschemic heart...
Published: 9/5/2023
|
Inventor(s):
Song Li
Keywords(s):
Category(s):
Platforms > Drug Delivery
,
Platforms > Drug Delivery > Peptide Base
,
Platforms > Drug Delivery > Viral Delivery Systems
,
Therapeutics
,
Therapeutics > Cardiovascular
2020-421 EXTRACELLULAR VESICLES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS FOR IMMUNOMODULATION
UCLA researchers in the Department of Bioengineering have developed a method to boost extracellular vesicles' (EVs) production and potency, potentially allowing large-scale clinical-grade EV manufacture for immunomodulatory therapeutics. BACKGROUNDExtracellular vesicles (EVs) are one of the most important mediators of cell-to-cell communication. EVs...
Published: 7/19/2023
|
Inventor(s):
Jana Zarubova
,
Mohammad Hasani-Sadrabadi
,
Song Li
Keywords(s):
Immunology
,
Therapeutics & Vaccines
,
Transplant Rejection
Category(s):
Life Science Research Tools > Research Methods
,
Therapeutics > Agtech And Animal Health
,
Therapeutics > Inflammation And Inflammatory Diseases
,
Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
2020-887 A Programmable Epidermal Microfluidic Valving System for Wearable Biofluid Management and Contextual Biomarker Analysis
SUMMARYResearchers in the UCLA Electrical and Computer Engineering Department have devised a programmable epidermal microfluid valving system for high frequency, real-time biofluid sampling, routing, and compartmentalization in wearable bioanalytical platforms.BACKGROUNDWearable biomarker sensing technologies allow for the frequent, longitudinal, and...
Published: 7/19/2023
|
Inventor(s):
Sam Emaminejad
,
Haisong Lin
,
Jiawei Tan
Keywords(s):
Category(s):
Electrical > Electronics & Semiconductors
,
Electrical > Sensors
,
Life Science Research Tools > Microfluidics And Mems
,
Medical Devices > Monitoring And Recording Systems
,
Platforms > Diagnostic Platform Technologies
2020-451 AMIOTIC MEMBRANE FOR MYOCARDIAL REPAIR
UCLA researchers in the Department of Bioengineering have developed a novel injectable human amniotic membrane matrix for the treatment of heart failure.BACKGROUND: Myocardial infarction (MI) associated heart failure is the leading cause of death in the United States. In 2015, heart failure affected about 40 million people worldwide. Around 2% of adults...
Published: 7/19/2023
|
Inventor(s):
Song Li
,
Randall Lee
Keywords(s):
Cardiovascular
,
Therapeutics & Vaccines
Category(s):
Therapeutics > Cardiovascular
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