Search Results - diagnostic+markers+%3e+targets+and+assays

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A Novel Biomarker and Therapeutic Target for Atrial Fibrillation in Humans (UCLA Case No. 2024-041)

UCLA researchers at the Geffen School of Medicine have identified a novel biomarker and therapeutic target for early diagnosis and treatment of post-operative atrial fibrillation. BACKGROUND: Post-operative atrial fibrillation (POAF) is a common complication following cardiac surgery, affecting 30-50% of patients. Patients who develop POAF have an...

Published: 3/26/2026 | Inventor(s): Thomas Vondriska, Matthew Fischer

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular

DNA Methylation Biomarkers to Predict Chronic Lung Allograft Dysfunction (UCLA Case No. 2025-9A0)

UCLA researchers in the Department of Medicine have developed a logistic regression model using DNA methylation biomarkers that enables early, noninvasive prediction of chronic lung allograft dysfunction up to two years before clinical disease onset. BACKGROUND: Chronic lung allograft dysfunction (CLAD) is the leading cause of long-term graft failure...

Published: 2/25/2026 | Inventor(s): Joanna Schaenman

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Respiratory And Pulmonary, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Bioinformatics, Software & Algorithms > Statistical Models

Compositions and Methods to Modulate MAVS-Mediated Immunity (UCLA Case No. 2026-096)

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed methods to target TOM70, a mitochondrial outer membrane protein, to selectively modulate innate immune signaling and control pathological or protective immune responses across a range of clinical conditions. BACKGROUND: Innate immune detection of viral...

Published: 2/18/2026 | Inventor(s): Lena Pernas

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Autoimmune, Therapeutics > Vaccines

An Acoustic Device for Large Area Single Cell Trapping and Selective Release (Case No. 2025-047)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an acoustic microfluidic platform that offers a cost-effective and practical approach for handling individual cells at the microscale. Background: Single-cell manipulation is essential for understanding cellular behavior, disease progression, and therapeutic...

Published: 1/13/2026 | Inventor(s): Pei-Yu Chiou, Xiang Zhang

Keywords(s): acoustic microfluidics, acoustic potential wells, acoustics, cell proliferation, cell viability, Diagnostic Platform Technologies (E.G. Microfluidics), diagnostic platforms, Digital Microfluidics, disposable microfluidic platforms, high throughput, high throughput assays, high throughput testing, High-Content Screening, high-throughput cell handling, low-cost fabrication, MEMS, MEMS metasurface, micro-electromechanical systems (MEMS), Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared laser, photolithography-free fabrication, research instrumentation, scalable platform, single cell analysis, single cell analysis and testing, Single cell data, single-cell handling, single-cell manipulation, single-cell resolution, single-cell trapping

Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Mechanical, Mechanical > Instrumentation, Platforms, Platforms > Diagnostic Platform Technologies

Oral-Gut-Brain Axis Virome/Microbiome for Periodontitis, Irritable Bowel Disease and Alzheimer’s Disease Diagnostics (UCLA Case No. 2024-222)

UCLA researchers in the School of Dentistry and section of Biosystems and Function have developed a novel diagnostic protocol to accurately categorize both the virome and microbiome of the oral-gut-brain axis for periodontitis, irritable bowel disease, and Alzheimer’s disease pathologies. BACKGROUND: Humans are host to a large and diverse set...

Published: 1/7/2026 | Inventor(s): Yvonne Kapila

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

Generation of Therapeutic Human Anti-Trop-2 Extracellular Domain Antibodies (UCLA Case No. 2026-026)

UCLA researchers from the Department of Molecular and Medical Pharmacology and the Department of Microbiology, Immunology and Molecular Genetics have developed a panel of human antibodies and chimeric antigen receptors targeting Trop-2, providing diagnostic and therapeutic resources for targeting Trop2-driven cancer. BACKGROUND: Trophoblast cell surface...

Published: 12/23/2025 | Inventor(s): Tanya Stoyanova, Owen Witte

Keywords(s):

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Antibodies, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

NPEPPS Enhancers for Treating Tau-Induced Neurodegeneration (UCLA Case No. 2018-161)

UCLA researchers from the Department of Neurology have developed first-in-class small-molecule activators of NPEPPS that effectively lower pathological tau, offering a novel disease-modifying strategy for Alzheimer’s and other neurodegenerative disorders. BACKGROUND: Neurodegenerative dementias such as Alzheimer’s Disease (AD) and progressive...

Published: 10/22/2025 | Inventor(s): Daniel Geschwind, Robert Damoiseaux, Liting Deng, Michael Jung, Jennifer Murphy, Gaoyuan Ma

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Diagnostic Markers > Targets And Assays

Use of Blood, Bronchoalveolar Lavage Fluid (BALF) or Urine Cytokines Combined With Donor-Derived Cell-Free DNA (dd-cfDNA) as a Biomarker of Allograft (UCLA Case No. 2025-316)

UCLA researchers in the Department of Pulmonology have identified a novel non-invasive combinatorial biomarker for prediction, early detection, and monitoring of acute and chronic allograft injury. BACKGROUND: Post-surgery treatment and rejection surveillance for solid organ transplantation remains challenging, primarily due to a limited ability to...

Published: 10/3/2025 | Inventor(s): Yusaku Shino

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies

Antiviral Compounds Inhibiting Zika Virus (ZIKV), and Methods and Zika Treatment Thereof (UCLA Case No. 2025-241)

UCLA researchers from the Molecular and Medical Pharmacology Department and CNSI have identified antiviral compounds that effectively inhibit Zika virus infection and cytopathic effects, potentially leading to improved therapeutics and treatment outcomes. BACKGROUND: Zika virus (ZIKV), a flavivirus now endemic to several regions globally, can cause...

Published: 10/3/2025 | Inventor(s): Vaithilingaraja Arumugaswami, Robert Damoiseaux

Keywords(s):

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Therapeutics > Infectious Diseases, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Platforms > Diagnostic Platform Technologies

A Nanoengineered Immunosensor to Detect Multiple Circulating Biomarkers for Rapid Prediction of Acute Thrombosis (UCLA Case No. 2025-015)

UCLA researchers in the Department of Cardiology have developed a nanoengineered immune sensor that uses machine learning to detect multiple circulating biomarkers for rapid, accurate prediction of acute thrombosis. BACKGROUND: Acute thrombosis represents a significant contributor to both acute and chronic illnesses. Moreover, the correlation between...

Published: 11/25/2025 | Inventor(s): Tzung Hsiai

Keywords(s):

Category(s): Materials > Nanotechnology, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular, Diagnostic Markers > Targets And Assays, Medical Devices > Monitoring And Recording Systems, Software & Algorithms > Artificial Intelligence & Machine Learning

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