Search Results - diagnostic+markers+%3e+targets+and+assays

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Saliva Anti-SSA/Ro IgA1 Differentiates Sjögren’s from Non-Sjögren’s Syndrome Patients (UCLA Case No. 2023-292)

UCLA researchers in the Department of Dentistry have developed a novel methodology to accurately differentiate patients with Sjögren’s Disease from non-Sjögren’s Disease patients by monitoring saliva IgA1 forms, enabling more accurate tracking of disease progression. BACKGROUND: The presence and detection of autoantibodies within...

Published: 3/14/2025 | Inventor(s): David Wong

Keywords(s):

Category(s): Therapeutics > Autoimmune, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Ophthalmology

Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...

Published: 2/26/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz

Keywords(s):

Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular

Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)

Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...

Published: 3/3/2025 | Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman

Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy

Salivary Exosome (NSEV) Analysis to Elucidate Intercellular Signaling Events that Precede Pilot Fatigue (UCLA Case No. 2021-172)

Researchers at UCLA’s Department of Neurology and Drug Discovery Lab have identified a novel set of biomarkers that change based on levels of Cognitive Fatigue (CF). These biomarkers can be used to non-invasively predict and assess levels of cognitive fatigue. BACKGROUND: Cognitive fatigue (CF) is an important factor in the efficiency and safety...

Published: 2/14/2025 | Inventor(s): Bruce Teter, Whitaker Cohn, Varghese John

Keywords(s): biomarkers, cognitive fatigue, exosome, noninvasive, non-invasive

Category(s): Diagnostic Markers > Targets And Assays

Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)

Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo

Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays

Development of Novel Compounds to Suppress Neuronal Stress and Cross the Blood Brain Barrier (UCLA Case No. 2021-165)

SUMMARY: An interdisciplinary group of UCLA researchers have developed and validated a library of compounds that alleviate symptoms of Rett Syndrome and hold enormous therapeutic potential for the long-term treatment of other intellectual disability syndromes. BACKGROUND: Intellectual disability (ID) affects more than 100 million people globally and...

Published: 2/14/2025 | Inventor(s): William Lowry, Michael Jung, Xiaoguang Liu, Elena Korsakova

Keywords(s): blood-brain barrier, Drug, intellectual disability, Organoids, senescence

Category(s): Therapeutics > CNS and Neurology, Life Science Research Tools, Diagnostic Markers > Targets And Assays

Detection of Dicrotic Notch in Arterial Pressure and Photoplethysmography Signals Using Iterative Envelope Mean Filter (Case No. 2024-034)

Summary: UCLA Researchers in the Department of Anesthesiology have developed an iterative envelope mean (IEM) method for the detection of specific features in arterial pressure monitoring applications. Background: The cardiac cycle consists of the distinct systolic and diastolic phases. The transition from the contracted, systolic phase to the...

Published: 3/26/2025 | Inventor(s): Maxime Cannesson, Ravi Pal, Akos Rudas, Jeffrey Chiang, Sungsoo Kim

Keywords(s): arrhythmia, arterial blood pressure (ABP), cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, diastolic, diastolic phase peak, dicrotic notch, feature extraction tool, iterative envelope method (IEM), Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, non-invasive cardiac monitoring, photoplethysmography (PPG), Smart medical device, systolic, tachycardia, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Software & Algorithms, Diagnostic Markers > Targets And Assays, Diagnostic Markers

Field-Effect Transistor Biosensors Integrated With Porous Media (Case No. 2023-093)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering in collaboration with the University of Chicago have developed a new diagnostic biosensor by combining field-effect transistors with porous media. Background: Point-of-care (POC) and self-testing tools rely on the real-time monitoring of biomarkers in bodily fluids....

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Hyouarm Joung, Hyun-June Jang, Junhong Chen

Keywords(s): Biomarker, biomarkers, Biomaterial, Biosensor, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Electrical, Electrical Engineering, electrically-mediated sensing, electrochemical sensors, enzyme functionalization, field-effect transistors (FETs), Medical diagnostics, multiplexed analysis, Point Of Care, point-of-care, porous media, sample matrix effects, transistors

Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms, Platforms > Diagnostic Platform Technologies

Swabseq Agnostic Diagnostic Platform (Case No. 2023-293)

Summary: UCLA researchers in the Departments of Computer Science and Anatomic Pathology have developed an untargeted NGS diagnostic tool capable of detecting all known and emerging respiratory RNA viruses in a single test, enhancing our capacity to rapidly address public health crises through improved diagnostics. Background: Most clinical diagnostic...

Published: 3/20/2025 | Inventor(s): Eleazar Eskin, Valerie Arboleda

Keywords(s): agnostic detection, Bioinformatics, bioinformatics pipeline, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Test, DNA Sequencing, Medical diagnostics, metagenomic diagnostic platform, meta-genomics, next generation sequencing (NGS), Pathogen, Pathogenesis, Sequencing

Category(s): Platforms, Platforms > Diagnostic Platform Technologies, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics

Core-Shell Hydrogel Particles With Tunable Porosity for Digital Nucleic Acid Assays (Case No. 2023-058)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel method to perform ultra-high sensitivity, low-cost nucleic acid amplification assays utilizing porous microdroplets. Background: Nucleic acid concentration measurement is essential in biological research and diagnostics. The 2020 pandemic underscored the importance...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Michael Bogumil

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Flow Cytometry, Medical diagnostics

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Chemical > Emulsions, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

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