Search Results - therapeutics+%3e+musculoskeletal+disease

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Increasing Linear Growth in Osteogenesis Imperfecta (UCLA Case No. 2025-258)

UCLA researchers from the Department of Orthopedic Surgery, OBGYN, and Human Genetics have identified the drug infigratinib as a potential therapeutic to treat osteogenesis imperfecta (OI). BACKGROUND: Osteogenesis Imperfecta (OI) is a heterogeneous genetic condition that can be characterized by brittle bones, recurrent fractures, and short stature....

Published: 10/1/2025 | Inventor(s): Deborah Krakow

Keywords(s):

Category(s): Therapeutics > Musculoskeletal Disease

TRP: Cell Lines Expressing a DNA Construct Expressing Mutant TRPV4 (UCLA Case No. 2021-361)

UCLA researchers from the Department of Molecular, Cell, and Developmental Biology have developed stable cell lines expressing wild-type or disease-associated mutant TRPV4 channels, providing a powerful platform for mechanistic and drug discovery studies. BACKGROUND: TRPV4 is a non-selective cation channel that regulates calcium influx in response...

Published: 10/1/2025 | Inventor(s): Daniel Cohn

Keywords(s):

Category(s): Life Science Research Tools > Cell Lines, Therapeutics > Musculoskeletal Disease, Therapeutics > CNS and Neurology

Composite Bone Regenerative Material (UCLA Case No. 2025-048)

Contact UCLA Technology Development Group to learn more. Related publications (by the inventors only): Resorbable Poly-(D,L)-Lactide Anchorage of Nanoparticulate Mineralized Collagen Materials Maximizes In Vivo Skull Regeneration Meiwand Bedar, Xiaoyan Ren, Wei Chen, Youngnam Kang, Shahrzad Moghadam, Kelly X. Huang, Kaavian Shariati, Brendan A.C....

Published: 9/18/2025 | Inventor(s): Justine Lee, Brendan Harley

Keywords(s):

Category(s): Medical Devices > Surgical Tools, Therapeutics > Musculoskeletal Disease, Therapeutics > Orthopaedics

Inorganic Ion Eluting Nanoparticulate Mineralized Collagen Glycosaminoglycan Materials (UCLA Case No. 2023-140)

UCLA researchers from the Division of Plastic and Reconstructive Surgery at the UCLA David Geffen School of Medicine have developed an innovative inorganic ion-eluting nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) material designed for advanced tissue regeneration, particularly bone repair. INNOVATION: UCLA researchers led by Professor...

Published: 9/18/2025 | Inventor(s): Justine Lee

Keywords(s):

Category(s): Medical Devices > Surgical Tools, Therapeutics > Musculoskeletal Disease, Therapeutics > Orthopaedics

Methods and Systems for Low-Cost Medical Image Annotation Using Non-experts (Case No. 2025-108)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an AI-based interface designed to enable individuals without specialized training to identify arthritis in medical imaging. Background: The use of artificial intelligence (AI) for medical imaging analysis holds great promise for the future of healthcare....

Published: 7/23/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang

Keywords(s): 3D tissue imaging, AI-guided diagnostics, AI-guided medical imaging, AI-guided medical intervention, arthritis, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, Artificial Neural Network, bioimaging, Computer-Aided Diagnosis, computer-aided radiology, Diagnostic Markers & Platforms, Diagnostic Test, diagnostics, generative artificial intelligence, Image Analysis, Image Resolution, Imaging, infrared thermal imaging, Machine Learning, machine learning modeling, machine perception, Magnetic Resonance Imaging Medical Physics, Magnetic Resonance Imaging Pathology, Medical artificial intelligence (AI), Medical diagnostics, Medical Imaging, Microscopy And Imaging, non-invasive imaging, osteoarthritis, radial MRI, radiologic imaging, Radiology, Radiology / Radiomitigation, radiosurgery

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Radiology

Compliant Wrist Reconstruction (Case No. 2023-261)

Summary: Researchers in the Mechanical Engineering Department at UCLA have developed a compliant wrist implant as an alternative to current wrist arthroplasty devices. Background: Conventional wrist replacements often lack the longevity and stability required to make total wrist arthroplasty (TWA) the preferred treatment for active patients with...

Published: 8/21/2025 | Inventor(s): Tyler Clites, Lauren Wessel, Jonathan Hopkins, Leonardo Ruffini, Armin Pomeroy, Nelson Soohoo

Keywords(s): biomedical implantation, compliant mechanisms, constraint design, device stability, fusion, Implant (Medicine), multi-degrees of freedom (DOF), Orthopaedics, Orthopedics and Prosthetics (O & P)

Category(s): Medical Devices > Prosthetics, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease

Bone Depth Gauge Design and Deployable Mechanism (Case No. 2024-185)

Summary: Researchers in the Department of Head and Neck Surgery at UCLA have developed a novel bone depth gauge and deployable mechanism for orthopaedic screw insertion. Background: Orthopaedic screws are typically used in surgeries to treat fractures that may have been caused intentionally, such as for tumor resection or joint replacement, or...

Published: 8/21/2025 | Inventor(s): Ashley Kita, Eric Smith, Rhorie Kerr

Keywords(s): bone health, Invasiveness Of Surgical Procedures, Orthopaedics, Orthopedics and Prosthetics (O & P), Surgical Instrument, surgical tool

Category(s): Diagnostic Markers > Aging, Mechanical > Sensors, Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease, Therapeutics > Inflammation And Inflammatory Diseases

Metamorphic Hybrid Compliant Mechanisms (Case No. 2025-038)

Summary: Researchers in the Mechanical Engineering Department at UCLA have developed a compliant technique that can be utilized for a wide array of industries, including next-generation joint reconstruction surgeries, precision manufacturing, robotics, aerospace transportation, and automation applications. Background: Bearings are commonly used to...

Published: 6/25/2025 | Inventor(s): Tyler Clites, Cameron Taylor, He Kai Lim, Jonathan Hopkins

Keywords(s): Aeronautics, Aerospace Engineering, Automation, biomedical implantation, compliant mechanisms, constraint design, Energy Efficiency, flexure systems, Implant (Medicine), multi-degrees of freedom (DOF), Orthopaedics, Orthopedics and Prosthetics (O & P), Robotics

Category(s): Mechanical > Aeronautics & Aerospace, Mechanical > Robotics, Mechanical > Manufacturing, Mechanical > Instrumentation, Mechanical > Mechanical Systems, Medical Devices > Prosthetics, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Materials, Therapeutics > Musculoskeletal Disease

Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...

Published: 7/17/2025 | Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova

Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease

Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)

Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...

Published: 8/21/2025 | Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu Zheng

Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers

Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease

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