Search Results - therapeutics+%3e+musculoskeletal+disease

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Compliant Wrist Reconstruction (Case No. 2023-261)

Summary: Researchers in the Mechanical Engineering Department at UCLA have developed a compliant wrist implant as an alternative to current wrist arthroplasty devices. Background: Conventional wrist replacements often lack the longevity and stability required to make total wrist arthroplasty (TWA) the preferred treatment for active patients with...

Published: 6/17/2025 | Inventor(s): Tyler Clites, Lauren Wessel, Jonathan Hopkins, Leonardo Ruffini, Armin Pomeroy, Nelson Soohoo

Keywords(s): biomedical implantation, compliant mechanisms, constraint design, device stability, fusion, Implant (Medicine), multi-degrees of freedom (DOF), Orthopaedics, Orthopedics and Prosthetics (O & P)

Category(s): Medical Devices > Prosthetics, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease

Bone Depth Gauge Design and Deployable Mechanism (Case No. 2024-185)

Summary: Researchers in the Department of Head and Neck Surgery at UCLA have developed a novel bone depth gauge and deployable mechanism for orthopaedic screw insertion. Background: Orthopaedic screws are typically used in surgeries to treat fractures that may have been caused intentionally, such as for tumor resection or joint replacement, or...

Published: 4/11/2025 | Inventor(s): Ashley Kita, Eric Smith, Rhorie Kerr

Keywords(s): bone health, Invasiveness Of Surgical Procedures, Orthopaedics, Orthopedics and Prosthetics (O & P), Surgical Instrument, surgical tool

Category(s): Diagnostic Markers > Aging, Mechanical > Sensors, Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease, Therapeutics > Inflammation And Inflammatory Diseases

Metamorphic Hybrid Compliant Mechanisms (Case No. 2025-038)

Summary: Researchers in the Mechanical Engineering Department at UCLA have developed a compliant technique that can be utilized for a wide array of industries, including next-generation joint reconstruction surgeries, precision manufacturing, robotics, aerospace transportation, and automation applications. Background: Bearings are commonly used to...

Published: 6/25/2025 | Inventor(s): Tyler Clites, Cameron Taylor, He Kai Lim, Jonathan Hopkins

Keywords(s): Aeronautics, Aerospace Engineering, Automation, biomedical implantation, compliant mechanisms, constraint design, Energy Efficiency, flexure systems, Implant (Medicine), multi-degrees of freedom (DOF), Orthopaedics, Orthopedics and Prosthetics (O & P), Robotics

Category(s): Mechanical > Aeronautics & Aerospace, Mechanical > Robotics, Mechanical > Manufacturing, Mechanical > Instrumentation, Mechanical > Mechanical Systems, Medical Devices > Prosthetics, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Materials, Therapeutics > Musculoskeletal Disease

Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...

Published: 2/14/2025 | Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova

Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease

Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)

Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...

Published: 2/14/2025 | Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu Zheng

Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers

Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease

Pharmacologic Intervention to Reduce the Risk of Episodic Weakness and Enhance Recovery from On-Going Episode of Weakness in Periodic Paralysis (UCLA Case No. 2022-274)

Researchers in the Department of Physiology in the School of Medicine have identified a novel method for the treatment of periodic paralysis. This approach focuses on a type of potassium channel that the team has newly discovered which can be modulated to relieve or prevent episodes of periodic paralysis with an FDA-approved drug. BACKGROUND: Periodic...

Published: 2/14/2025 | Inventor(s): Stephen Cannon

Keywords(s): Drug repurposing, Muscle weakness, Paralysis, Periodic paralysis

Category(s): Medical Devices, Therapeutics > Musculoskeletal Disease, Therapeutics > Genetic Diseases

Implanted Digital Prosthesis (Case No. 2022-298)

Summary: UCLA Researchers in the Department of Mechanical and Aerospace Engineering have developed a novel finger prosthetic attachment mechanism and skin-transfer procedure that allows for better prosthetic motion and functionality while allowing the user to feel “natural” sensations. Background: Limb amputations typically cause a loss...

Published: 3/13/2025 | Inventor(s): Tyler Clites, Gracia Lai, Kodi Azari, Lauren Wessel

Keywords(s): Biosensor, Medical Device, Medical Devices and Materials, Musculoskeletal Disease, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Sensors, Sensory System, Smart medical device, wearable medical device

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Mechanical, Mechanical > Robotics, Medical Devices, Medical Devices > Neural Stimulation, Medical Devices > Surgical Tools, Therapeutics, Therapeutics > Musculoskeletal Disease, Medical Devices > Prosthetics

2021-003 A Chemical Cocktail Driving Expansion of Myogenic Stem Cells

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel chemical cocktail for enhancing myogenic stem cell expansion both in vitro and in situ that could lead to more affordable and faster development of stem cell-based therapies and chemical delivery technologies for muscle regeneration. BACKGROUND: Skeletal muscle tissue...

Published: 2/14/2025 | Inventor(s): Song Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Musculoskeletal Disease

2021-218 Hierarchically Structured Hydrogel With Broad-range Tunable Mechanical Properties

SUMMARY: UCLA researchers in the Department of Materials Science and Engineering have developed a method to create hydrogels with tunable strength, mechanical strain, toughness, and fatigue resistance. BACKGROUND: Hydrogels are used in a wide range of applications such as tissue engineering, drug delivery, and energy storage devices. But despite...

Published: 2/14/2025 | Inventor(s): Ximin He, Mutian Hua, Shuwang Wu

Keywords(s):

Category(s): Chemical > Polymers, Medical Devices > Coatings, Therapeutics > Musculoskeletal Disease

Preventing Skeletal Aging and Osteoporosis (UCLA Case No. 2020-753)

UCLA Researchers in the Department of Dentistry have discovered that a novel drug combination results in a synergistic therapeutic effect for osteoporosis treatment. BACKGROUND: It is estimated that 10 million men and women in the U.S. suffer from osteoporosis; a metabolic bone disease that is characterized by low bone density and deterioration...

Published: 6/26/2025 | Inventor(s): Cun Yu Wang

Keywords(s): Osteo, Osteoporosis

Category(s): Therapeutics > Musculoskeletal Disease

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