Search Results - therapeutics+%3e+musculoskeletal+disease

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Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...

Published: 5/8/2024 | Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova

Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease

Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)

Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...

Published: 7/9/2024 | Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng

Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers

Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease

Pharmacologic Intervention to Reduce the Risk of Episodic Weakness and Enhance Recovery from On-Going Episode of Weakness in Periodic Paralysis (UCLA Case No. 2022-274)

Researchers in the Department of Physiology in the School of Medicine have identified a novel method for the treatment of periodic paralysis. This approach focuses on a type of potassium channel that the team has newly discovered which can be modulated to relieve or prevent episodes of periodic paralysis with an FDA-approved drug. BACKGROUND: Periodic...

Published: 2/23/2024 | Inventor(s): Stephen Cannon

Keywords(s): Drug repurposing, Muscle weakness, Paralysis, Periodic paralysis

Category(s): Medical Devices, Therapeutics > Musculoskeletal Disease, Therapeutics > Genetic Diseases

2022-298 Implanted Digital Prosthesis

Summary: UCLA Researchers in the Department of Mechanical and Aerospace Engineering have developed a novel finger prosthetic attachment mechanism and skin-transfer procedure that allows for better prosthetic motion and functionality while allowing the user to feel “natural” sensations. Background: Limb amputations typically cause a loss...

Published: 10/8/2024 | Inventor(s): Tyler Clites, Gracia Lai, Kodi Azari, Lauren Wessel

Keywords(s): Biosensor, Medical Device, Medical Devices and Materials, Musculoskeletal Disease, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Sensors, Sensory System, Smart medical device, wearable medical device

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Mechanical, Mechanical > Robotics, Medical Devices, Medical Devices > Neural Stimulation, Medical Devices > Surgical Tools, Therapeutics, Therapeutics > Musculoskeletal Disease, Medical Devices > Prosthetics

2021-003 A Chemical Cocktail Driving Expansion of Myogenic Stem Cells

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel chemical cocktail for enhancing myogenic stem cell expansion both in vitro and in situ that could lead to more affordable and faster development of stem cell-based therapies and chemical delivery technologies for muscle regeneration. BACKGROUND: Skeletal muscle tissue...

Published: 8/25/2023 | Inventor(s): Song Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Musculoskeletal Disease

2021-218 Hierarchically Structured Hydrogel With Broad-range Tunable Mechanical Properties

SUMMARY: UCLA researchers in the Department of Materials Science and Engineering have developed a method to create hydrogels with tunable strength, mechanical strain, toughness, and fatigue resistance. BACKGROUND: Hydrogels are used in a wide range of applications such as tissue engineering, drug delivery, and energy storage devices. But despite...

Published: 7/19/2023 | Inventor(s): Ximin He, Mutian Hua, Shuwang Wu

Keywords(s):

Category(s): Chemical > Polymers, Medical Devices > Coatings, Therapeutics > Musculoskeletal Disease

2020-753 PREVENTING SKELETAL AGING AND OSTEOPOROSIS

UCLA Researchers in the Department of Dentistry have discovered that a novel drug combination results in a synergistic therapeutic effect for osteoporosis treatment. BACKGROUND: It is estimated that 10 million men and women in the U.S. suffer from osteoporosis; a metabolic bone disease that is characterized by low bone density and deterioration...

Published: 7/19/2023 | Inventor(s): Cun-Yu Wang

Keywords(s): Osteo, Osteoporosis

Category(s): Therapeutics > Musculoskeletal Disease

2019-845 Non-Invasive Neuromodulatory Means to Maintain Blood Pressure and Respiration in Conditions with Compromised Breathing or Cardiovascular Control

SUMMARYUCLA researchers in the Department of Neurobiology have developed a non-invasive, non-electrical neuromodulatory system that uses vibratory stimulation of cranial and cervical nerves of the auditory canal to abolish breathing disorders while maintaining blood pressure.BACKGROUNDSleep disturbed breathing and related cardiovascular disorders such...

Published: 7/19/2023 | Inventor(s): Ronald Harper, Eberhardt Sauerland

Keywords(s):

Category(s): Medical Devices > Monitoring And Recording Systems, Therapeutics > Cardiovascular, Therapeutics > Musculoskeletal Disease, Therapeutics > CNS and Neurology

2019-898 NEURAL CREST STEM CELL THERAPIES FOR DENERVATION ATROPHY

UCLA researchers in the Department of Bioengineering have developed an innovative cell-based therapy addressing the recovery from denervation atrophy by intramuscularly delivering neural crest stem cells in various constructs.BACKGROUND:Muscular denervation atrophy of various etiologies can result in weakness or loss of functional independence, as well...

Published: 7/19/2023 | Inventor(s): Song Li, Yuan-Yu Hsueh

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics > Musculoskeletal Disease

2019-540 ANTI CELLULAR STRESS TREATMENT TO IMPROVE PULMONARY FUNCTION IN DISORDERS WITH ER STRESS

INTRODUCTION: UCLA researchers in the Department of Orthopedic Surgery have studied a series of anti-stress compounds that ameliorate the genetic defects of patients with Osteogenesis Imperfecta. BACKGROUND: Over the past decade researchers have begun to discover a common underlying pathway for several diseases, Endoplasmic Reticulum (ER) stress. The...

Published: 9/14/2023 | Inventor(s): Ivan Duran Jimenez

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics > Musculoskeletal Disease

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