Search Results - therapeutics+%3e+autoimmune

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A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)

Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...

Published: 1/24/2024 | Inventor(s): Rhonda Voskuhl, Michael Jung

Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics

2022-017: Single and Multi-Epitope Peptide and mRNA Vaccines to Generate Tolerogenic Effects for Allergic and Autoimmune Disease by Targeting Liver Sinusoidal Endothelial Cells

SUMMARY: UCLA researchers in the School of Medicine and California NanoSystems Institute have developed a novel treatment method utilizing intravenously-delivered nanoparticles loaded with epitopes that interfere with the anaphylaxis response for sustained tolerance to food allergens. BACKGROUND: The U.S. Food and Drug Administration (FDA) defines...

Published: 9/5/2023 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Therapeutics, Therapeutics > Autoimmune, Therapeutics > Vaccines

2019-839 Self-Modulating T Cells with Robust Anti-Tumor Efficacy and Reduced Propensity for Triggering Severe Cytokine Release Syndrome

SUMMARY: Researchers from UCLA’s Department of Microbiology, Immunology and Molecular Genetics have developed methods for generating self-modulating CAR-T cells which retain robust anti-tumor function whilst having reduced adverse side effects relating to cytokine release syndrome. BACKGROUND: The immunotherapy approach of T-cell engineering...

Published: 9/11/2023 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

2020-152 Method to Clone Human T Cell Receptors (TCRs) from Single Lymphocytes Based on Functional Profiling

SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to clone human T cell receptors from single lymphocytes. BACKGROUND: Immunotherapy is a growing therapy type for the treatment of disease, especially cancer, by activating or repressing the immune system. One major type...

Published: 7/19/2023 | Inventor(s): Owen Witte, Jami Witte, Pavlo Nesterenko

Keywords(s):

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing

2022-057 NEW TREATMENT FOR SJOGREN'S SYNDROME

SUMMARY: UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel and safe therapeutic to ameliorate symptoms for the autoimmune disorder, Sjögren’s Syndrome. BACKGROUND: Sjögren’s syndrome (SS) is an autoimmune disorder that affects over 4 million people in the United States. Most commonly,...

Published: 3/18/2024 | Inventor(s): Daniel Kaufman

Keywords(s):

Category(s): Therapeutics, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2021-075 A New Drug Class Inhibits Illness and Death Due to Coronavirus Infection in Mice

Researchers from UCLA’s Department of Molecular and Medical Pharmacology have identified and validated a therapeutic target and an accompanying drug class which ameliorates illness and death due to Coronavirus infection. BACKGROUNDThere remains an urgent need for treatments that can reduce the symptoms for those infected by SARS-CoV-2, its future...

Published: 7/19/2023 | Inventor(s): Daniel Kaufman, Jide Tian

Keywords(s): Immunotherapy

Category(s): Therapeutics > Autoimmune, Therapeutics > Cardiovascular

2021-005 Liver-Targeting Tolerogenic Nanoparticles Encapsulating an Allergen T-Cell Epitope Impacts Eosinophilic Airway Inflammation with Comparable Efficacy as Pharmaceutical Tolerogenic Nanoparticles

UCLA researchers in the David Geffen School of Medicine and CNSI have developed a nanoparticle that induces antigen tolerance for use in treatment of allergy and autoimmune diseases. BACKGROUND: When the body’s immune overreacts against environmental allergens or falsely recognizes the body’s own molecular components as foreign, the results...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Autoimmune, Drug Delivery, Materials, Nanoparticles, Nanotechnology

Category(s): Materials > Nanotechnology, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2016-592 CATALYTIC MICRORNA ANTAGONISTS

Catalytic MicroRNA AntagonistsSUMMARYUCLA researchers in the Department of Biological Chemistry have developed a novel approach for miRNA inhibition.BACKGROUNDMicro RNA (miRNA) are short, 22 nucleotide RNA sequences. They play a critical role in post-transcription gene regulation and their mis-regulation is associated with different diseases such as...

Published: 7/19/2023 | Inventor(s): Feng Guo

Keywords(s): Autoimmune, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Autoimmune

2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 7/19/2023 | Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

2019-546 A METHOD FOR IDENTIFYING T CELLS WITH SPECIFIC ANTIGEN REACTIVITY

INTRODUCTION: UCLA researchers in the Department of Medicine have developed a novel method for the isolation of T cells reactive to specific antigens for use in cellular immunotherapy. BACKGROUND:T cell responses to proteins on antigen presenting cells is exceptionally antigen-specific. The identification of antigen-specific T cells, or the sequences...

Published: 4/26/2024 | Inventor(s): Christopher Seet, Gay Crooks

Keywords(s): Autoimmune, Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics > Autoimmune, Therapeutics > Infectious Diseases

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