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Search Results - life+science+research+tools+%3e+cell+lines
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2021-313 METHODS OF ANALYZING NANOVIALS CONTAINING CELLS USING FLUORESCENCE ACTIVATED CELL SORTING
Summary: UCLA researchers in the Department of Bioengineering have developed a high throughput, single cell screening and sorting platform to facilitate single cell functional assays. Background: Biological assays are usually performed using microwell plates because of their ability to scale experiments and integrate with current lab automation...
Published: 6/5/2024
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Inventor(s):
Dino Di Carlo
,
Joseph de Rutte
,
Robert Dimatteo
Keywords(s):
Assay
,
Biotechnology
,
Life Science Research Tools
,
Nanotechnology
,
Targets And Assays
Category(s):
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Research Methods
,
Materials > Functional Materials
,
Diagnostic Markers > Targets And Assays
,
Life Science Research Tools > Cell Counting And Imaging
,
Materials > Nanotechnology
2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS
Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...
Published: 7/19/2023
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Inventor(s):
Dino Di Carlo
,
Joseph de Rutte
,
Robert Dimatteo
,
Maani Archang
,
Robert Damoiseaux
,
Doyeon Koo
Keywords(s):
Antibody
,
B Cell
,
Bioassay
,
Cell Counting/Imaging
,
Cellular Differentiation
,
Cytometry
,
Flow Cytometry
,
Fluorescence
,
Hybridoma Technology
,
Secretory Component
,
T Cell
,
Targets And Assays
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Antibodies
,
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Research Methods
,
Life Science Research Tools > Other Reagents
,
Diagnostic Markers
,
Diagnostic Markers > Targets And Assays
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Platforms > Diagnostic Platform Technologies
2020-889 293T PACKAGING CELLS WITH TARGETED GENE KNOCKOUTS THAT IMPROVE LENTIVIRAL VECTOR TITERS
INTRODUCTIONUCLA researchers in the Department of Microbiology, Immunology, & Molecular Genetics have found that the knockout of four host cell antiviral factors could increase lentiviral titers, allowing the potential to reduce common off target toxicities of gene therapy while lowering the cost of treatment manufacturing. BACKGROUNDGene therapy...
Published: 11/15/2024
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Inventor(s):
Donald Kohn
Keywords(s):
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Cell Lines
,
Therapeutics
,
Therapeutics > Gene Therapy And Editing
Biocompatible, Degradable Hollow Shell Particles for High-Throughput Screening and Sorting of Cells (Case No. 2021-026)
Summary: UCLA researchers in the Department of Bioengineering have developed a microfluidic technique that can encapsulate specific cells and separate them with fluorescence cell sorters. Background: The interest in cell-derived byproducts such as recombinant therapeutic proteins and antibody therapy has increased in the past years. Typically,...
Published: 11/15/2024
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Inventor(s):
Dino Di Carlo
,
Mark Van Zee
,
Joseph de Rutte
,
Sohyung Lee
Keywords(s):
Assay
,
Bioassay
,
Cell Growth
,
Fluorescence
,
Fluorescent Labelling
,
High-Content Screening
,
High-Throughput Screening
,
Nanotechnology
,
Screening Libraries
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Screening Libraries
,
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Cell Counting And Imaging
,
Materials > Nanotechnology
2020-495 Well Plate and Petri Dish Fluid Exchange Plug
SUMMARY: UCLA researchers in the Department of Bioengineering developed an automated fluidic and gas exchange system that is compatible with commercially available petri dishes, well and multi-well plates. BACKGROUND: In vitro assays are typically performed on commercially available petri dishes or well plates. While users can manually modify a dish/well...
Published: 7/3/2024
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Inventor(s):
Peyton Tebon
,
Darin Williams
Keywords(s):
Assay
,
Bioassay
,
biological assays
,
Cell Culture
,
cost-effective
,
fluidic exchange
,
gas exchange
,
Microwell plates
,
petri dish
,
sample environment
,
Targets And Assays
Category(s):
Life Science Research Tools > Cell Lines
,
Life Science Research Tools > Lab Equipment
,
Life Science Research Tools > Microscopy And Imaging
,
Life Science Research Tools > Cell Counting And Imaging
(XN) 2005-059 PTEN Null Cell Lines
PTEN Null Cell LinesBACKGROUNDPTEN (phsosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor gene identified to be frequently mutated/deleted in various human cancers. Besides carcinogenesis, Pten may play important roles in regulating stem cell activity, insulin action and development. PTEN is a member of the protein tyrosine...
Published: 7/19/2023
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Inventor(s):
Hong Wu
,
Daniel Freeman
Keywords(s):
Animal Models
,
Cell Lines
,
Life Science Research Tools
,
Oncology
Category(s):
Life Science Research Tools > Animal Models
,
Life Science Research Tools > Cell Lines
,
Life Science Research Tools
,
Therapeutics > Oncology
1996-568 Hybridoma Secreting Antibody to Mouse CD-1
Hybridoma that Secretes Antibody to Mouse CD1BACKGROUNDCD1d is a member of the CD1 family of antigen presenting molecules that display lipid antigens to T-cells. CD1d-restricted T-cells have been shown to have a role in antimicrobial responses, antitumor immunity, and the balance between tolerance and autoimmunity.INNOVATIONThe innovation allows researchers...
Published: 7/19/2023
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Inventor(s):
Mitchell Kronenberg
Keywords(s):
Category(s):
Life Science Research Tools > Cell Lines
2011-414 Human Fetal Prostate Cells for the Study of Human Tumors
Background Prostate cancer is one of the most common cancers to affect men and is the second leading cause of death amongst cancer victims. For decades, primary cultures of malignant prostatic cells have provided a convenient model system to study prostate cancer and tumorigenesis. However, these cell lines do not adequately recapitulate the microenvironment...
Published: 7/19/2023
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Inventor(s):
Keywords(s):
Category(s):
Life Science Research Tools > Cell Lines
2009-299 Supporting Cell Lines that Improve Gamete Production from Human Pluripotent Cells
Summary Scientists at UCLAs Broad Stem Cell Research Center have derived six human supporting cell lines that can be used in differentiation strategies to generate gametes from pluripotent stem cells. Background Pluripotent stem cells refer to any cell type that is capable of self-renewal and differentiation into embryonic and germ cell layers. Examples...
Published: 7/19/2023
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Inventor(s):
Keywords(s):
Category(s):
Life Science Research Tools > Cell Lines
2008-246 Induced Pluripotent Stem Cell Lines and Method to Generate Human Embryonic Stem Cells from Dermal Fibroblasts
Summary UCLA investigators have developed a method to generate human embryonic stem cell-like cells from human skin fibroblasts. These so-called induced pluripotent stem (iPS) cells have tremendous potential to create custom-made human embryonic stem cells to treat individuals with degenerative diseases. Background The use of stem cells to treat a variety...
Published: 7/19/2023
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Inventor(s):
Keywords(s):
Category(s):
Life Science Research Tools > Cell Lines
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