Search Results - therapeutics+%3e+inflammation+and+inflammatory+diseases

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Interferon Activation Score Is a Biomarker for Immunotherapy in Malignant Glioma Patients (UCLA Case No. 2024-043)

UCLA researchers from the Department of Neurosurgery have characterized immune responses in malignant glioma patients receiving immunotherapy to develop a robust biomarker that will allow prediction of clinical outcomes following treatment. BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults. No cures exist and most gliomas...

Published: 10/23/2024 | Inventor(s): Robert Prins

Keywords(s): adjuvant therapy, Biomarker, Chemotherapy, Clinical Trial, dendritic cell vaccination, Glioblastoma, Glioma, immune response, Immunotherapy, interferon, malignant glioma

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology, Therapeutics > CNS and Neurology

Quercetin as substrate for antiviral treatment against Hepatitis C virus infection (UCLA Case No. 2023-003)

UCLA researchers in the Department of Pathology and Hematology have developed a novel antiviral treatment for Hepatitis C virus based on the metabolic modulating properties of dietary compound Quercetin. BACKGROUND: Hepatitis C virus (HCV) is responsible for 180 million infections worldwide and over 12,000 deaths in the U.S. each year. Despite most...

Published: 5/16/2024 | Inventor(s): Nu Lu

Keywords(s): antivirals, hepatitis, immune metabolism, Inflammation, liver disease

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

2022-197 Novel Live Multi-Antigenic Recombinant Vaccine Against Tuberculosis

SUMMARY: Researchers at UCLA’s School of Medicine have developed a potent multi-antigen vaccine for protection against tuberculosis. BACKGROUND: Tuberculosis (TB) is an infectious disease that, when active, can affect many organs in the body but can especially cause severe lung disease manifest by chronic cough, fever, and weight loss, and, if...

Published: 2/23/2024 | Inventor(s): Marcus Horwitz

Keywords(s):

Category(s): Therapeutics, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Vaccines

2022-057 NEW TREATMENT FOR SJOGREN'S SYNDROME

SUMMARY: UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel and safe therapeutic to ameliorate symptoms for the autoimmune disorder, Sjögren’s Syndrome. BACKGROUND: Sjögren’s syndrome (SS) is an autoimmune disorder that affects over 4 million people in the United States. Most commonly,...

Published: 3/18/2024 | Inventor(s): Daniel Kaufman

Keywords(s):

Category(s): Therapeutics, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2021-260: THE INNATE IMMUNE HEALTH SCORE

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a strategy to quantitatively assess the functionality of macrophages, a key player of the innate immune system, using a paired experimental and computational strategy. BACKGROUND: The immune system is formed by two major inter-related components,...

Published: 10/4/2024 | Inventor(s): Alexander Hoffmann

Keywords(s):

Category(s): Software & Algorithms > Bioinformatics, Diagnostic Markers > Immunology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

Injectable Biodegradable Polymeric Complex for Glucose-Responsive Insulin Delivery (UCLA Case No. 2021-116)

Summary: UCLA researchers in the department of Bioengineering have developed a biodegradable material that is capable of releasing insulin in the presence of excess glucose mimicking the insulin secretion properties of pancreatic B-cells as a treatment for Diabetes Mellitus.Background: Diabetes mellitus currently affects more than 463 million people...

Published: 8/9/2024 | Inventor(s): Zhen Gu

Keywords(s):

Category(s): Platforms > Drug Delivery > Other Polymers, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology

2020-421 EXTRACELLULAR VESICLES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS FOR IMMUNOMODULATION

UCLA researchers in the Department of Bioengineering have developed a method to boost extracellular vesicles' (EVs) production and potency, potentially allowing large-scale clinical-grade EV manufacture for immunomodulatory therapeutics. BACKGROUNDExtracellular vesicles (EVs) are one of the most important mediators of cell-to-cell communication. EVs...

Published: 7/19/2023 | Inventor(s): Jana Zarubova, Mohammad Hasani-Sadrabadi, Song Li

Keywords(s): Immunology, Therapeutics & Vaccines, Transplant Rejection

Category(s): Life Science Research Tools > Research Methods, Therapeutics > Agtech And Animal Health, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2021-005 Liver-Targeting Tolerogenic Nanoparticles Encapsulating an Allergen T-Cell Epitope Impacts Eosinophilic Airway Inflammation with Comparable Efficacy as Pharmaceutical Tolerogenic Nanoparticles

UCLA researchers in the David Geffen School of Medicine and CNSI have developed a nanoparticle that induces antigen tolerance for use in treatment of allergy and autoimmune diseases. BACKGROUND: When the body’s immune overreacts against environmental allergens or falsely recognizes the body’s own molecular components as foreign, the results...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Autoimmune, Drug Delivery, Materials, Nanoparticles, Nanotechnology

Category(s): Materials > Nanotechnology, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2009-302 Translation Factors as Anti-aging Drug Targets

Summary Investigators at UCLA have discovered the target for resveratrol, an anti-aging compound, which may be useful for discovering a new class of anti-aging drugs. Background Aging is a natural state of development that reduces ones adaptivity and increases the incidence of disease. Several diseases, including cancer, atherosclerosis and neurodegeneration,...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Therapeutics > Inflammation And Inflammatory Diseases

2012-642 Diagnostic Tools for Response to 6-Thiopurine Therapy

Summary UCLA researchers have developed genetic and cytometric tests to predict patient responsiveness to 6-thiopurine therapy for autoimmune and inflammatory diseases. This technology has the potential to reduce the incidence of the serious adverse effects associated with 6-TP treatment, by averting its use in patients unlikely to benefit from 6-thiopurine...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Therapeutics > Inflammation And Inflammatory Diseases

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