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Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...

Published: 5/8/2024 | Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova

Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease

Cellphone-Based Micro-Plate Reader for Point-Of-Care ELISA Testing & High-Throughput and Automated Diagnosis of Antimicrobial Resistance

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a cost-effective cellphone-based micro-plate reader to rapidly perform antimicrobial susceptibility testing (AST) with >99% accuracy. Background: Immunoassays are biochemical tests that are conducted to measure the presence and concentration of...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Dino Di Carlo, Steve Feng, Bingen Cortazar Unzaga, Brandon Berg, Haydar Ozkan, Omai Garner, Kuochao Tseng

Keywords(s): Antibacterial, Antibiotic Resistance, Antibody, Artificial Intelligence, Bacteria, Drug Resistance, ELISA, High-Throughput Screening, Immunoassay, Nanotechnology, Optics, Photonics, Point Of Care, Smartphone

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Optics & Photonics, Software & Algorithms > Artificial Intelligence & Machine Learning

2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS

Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo

Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2019-772: A Single Chain Antibody That Binds Tau Oligomers and Inhibits Seeding by Pathological Extracts From Alzheimer’s Disease

SUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed a method for efficiently producing tau oligomers and a single-chain antibody against oligomeric tau protein with potential for theranostic utility in the treatment of Alzheimer’s and other tauopathies.BACKGROUND:Alzheimer’s disease (AD) is the most prevalent...

Published: 9/5/2023 | Inventor(s): David Eisenberg

Keywords(s): Amyloid, Antibodies, Central Nervous System, Genetic Disease, Life Science Research Tools, Neurodegeneration Alzheimer's Disease Predictive Testing, Tau Protein

Category(s): Life Science Research Tools > Antibodies, Therapeutics > CNS and Neurology

2021-002 System and Methods for Amplified Detection of Molecules on Microparticles

SUMMARYUCLA researchers in the Department of Bioengineering have developed a system to build immunocomplexes, generate and accumulate amplified signals, and perform the signal readout of a digital ELISA using standard benchtop instruments and techniques.BACKGROUNDDigital ELISA allows for the detection and measurement of protein biomarkers at a single-molecule...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Yilian Wang, Vishwesh Nilesh Shah

Keywords(s):

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Antibodies, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS

UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...

Published: 9/5/2023 | Inventor(s): Manish Butte, Fatemeh Sadat Majedi

Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy

2011-464 Polyclonal Antibody Recognizing the Human RIN2 Protein

Innovation RIN2 is a RAS effector protein with guanine nucleotide exchange factor (GEF) activity for RAB5 family GTPases. RIN2 is part of a cerebral cavernous malformations (CCM) signaling complex implicated in sporadic or inherited vascular lesions of the central nervous system. Additionally, RIN2 deficiencies are linked to the human connective tissue...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

2011-418 Novel Monoclonal Antibodies against Neospora Caninum

Summary UCLA researchers have developed a large number of highly specific monoclonal antibodies against the intracellular parasite Neospora caninum that can be used for diagnostic or research purposes.Background Apicomplexan parasites cause a wide array of diseases of medical and veterinary importance including malaria (Plasmodium spp.), toxoplasmosis...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

2010-810 Fusion Protein For Anti-Cd19 Chimeric Antigen Receptor Detection

Summary Researchers at UCLA have developed a fusion protein that can detect immune cells expressing anti-CD19 chimeric antigen receptors with higher specificity and lower background than existing antibodies. Background CD19, a glycoprotein specific to the B-cell lineage, is a target of a number of cancer immunotherapies. Clinical trials testing the...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

2009-592 Anti-S80 Phospho-Specific Mecp2 Antibody

Innovation MeCP2 is a methyl-CpG binding protein that binds methylated DNA to repress gene expression. Mutations in MeCP2 lead to neurodevelopmental disorders, including Rett syndrome, one of the most common causes of mental retardation in females. Phosphorylation of MeCP2 on a highly conserved serine residue (S80) is required for its roles in regulating...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

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