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A Novel Lymphocyte Stimulation Assay To Quantify Immune Responses (UCLA Case No. 2022-079)

UCLA researchers in the Department of Medicine have developed lymphocyte stimulation assays to evaluate immune responses, supporting various clinical applications such as adjusting immunosuppressant drug levels and advancing COVID-19 vaccine development. The assay systems are reliable, cost-effective, and easy-to-perform, providing accurate assessments...

Published: 2/14/2025 | Inventor(s): Yusaku Shino

Keywords(s): Antibody, biomarkers, cytokines, Immunity (Medical), immunosuppression, Organ Transplant

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Immunology And Immunotherapy

Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...

Published: 2/14/2025 | Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova

Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease

Cellphone-Based Micro-Plate Reader for Point-Of-Care ELISA Testing & High-Throughput and Automated Diagnosis of Antimicrobial Resistance

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a cost-effective cellphone-based micro-plate reader to rapidly perform antimicrobial susceptibility testing (AST) with >99% accuracy. Background: Immunoassays are biochemical tests that are conducted to measure the presence and concentration of...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Dino Di Carlo, Steve Feng, Bingen Cortazar Unzaga, Brandon Berg, Haydar Ozkan, Omai Garner, Derek Kuochao Tseng

Keywords(s): Antibacterial, Antibiotic Resistance, Antibody, Artificial Intelligence, Bacteria, Drug Resistance, ELISA, High-Throughput Screening, Immunoassay, Nanotechnology, Optics, Photonics, Point Of Care, Smartphone

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Optics & Photonics, Software & Algorithms > Artificial Intelligence & Machine Learning

2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS

Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo

Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2019-772: A Single Chain Antibody That Binds Tau Oligomers and Inhibits Seeding by Pathological Extracts From Alzheimer’s Disease

SUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed a method for efficiently producing tau oligomers and a single-chain antibody against oligomeric tau protein with potential for theranostic utility in the treatment of Alzheimer’s and other tauopathies.BACKGROUND:Alzheimer’s disease (AD) is the most prevalent...

Published: 2/14/2025 | Inventor(s): David Eisenberg

Keywords(s): Amyloid, Antibodies, Central Nervous System, Genetic Disease, Life Science Research Tools, Neurodegeneration Alzheimer's Disease Predictive Testing, Tau Protein

Category(s): Life Science Research Tools > Antibodies, Therapeutics > CNS and Neurology

2021-002 System and Methods for Amplified Detection of Molecules on Microparticles

SUMMARYUCLA researchers in the Department of Bioengineering have developed a system to build immunocomplexes, generate and accumulate amplified signals, and perform the signal readout of a digital ELISA using standard benchtop instruments and techniques.BACKGROUNDDigital ELISA allows for the detection and measurement of protein biomarkers at a single-molecule...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Yilian Wang, Vishwesh Nilesh Shah

Keywords(s):

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Antibodies, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS

UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...

Published: 2/14/2025 | Inventor(s): Manish Butte, Fatemeh Sadat Majedi

Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy

2011-464 Polyclonal Antibody Recognizing the Human RIN2 Protein

Innovation RIN2 is a RAS effector protein with guanine nucleotide exchange factor (GEF) activity for RAB5 family GTPases. RIN2 is part of a cerebral cavernous malformations (CCM) signaling complex implicated in sporadic or inherited vascular lesions of the central nervous system. Additionally, RIN2 deficiencies are linked to the human connective tissue...

Published: 2/14/2025 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

2011-418 Novel Monoclonal Antibodies against Neospora Caninum

Summary UCLA researchers have developed a large number of highly specific monoclonal antibodies against the intracellular parasite Neospora caninum that can be used for diagnostic or research purposes.Background Apicomplexan parasites cause a wide array of diseases of medical and veterinary importance including malaria (Plasmodium spp.), toxoplasmosis...

Published: 2/14/2025 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

2010-810 Fusion Protein For Anti-Cd19 Chimeric Antigen Receptor Detection

Summary Researchers at UCLA have developed a fusion protein that can detect immune cells expressing anti-CD19 chimeric antigen receptors with higher specificity and lower background than existing antibodies. Background CD19, a glycoprotein specific to the B-cell lineage, is a target of a number of cancer immunotherapies. Clinical trials testing the...

Published: 2/14/2025 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Antibodies

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