Search Results - life+science+research+tools+%3e+screening+libraries

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Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)

Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...

Published: 10/8/2024 | Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao

Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy

Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy

2022-258 Deep Learning-Enabled Detection and Classification of Bacterial Colonies Using a Thin Film Transistor (TFT) Image Sensor

Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed a thin-film transistor-based image sensor that can quantify and identify bacterial colony forming units (CFUs) with high accuracy using a deep-learning algorithm. Background: Bacterial infections are a leading cause of death every year in both developed...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Yuzhu Li, Tairan Liu

Keywords(s): Antibacterial, Artificial Neural Network, Bacteria, Holography, Machine Learning, Magnetic Resonance Imaging Carotid Artery Stenosis, Thin-Film Transistor, Transistor

Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Screening Libraries, Materials, Materials > Nanotechnology, Materials > Semiconducting Materials, Life Science Research Tools > Cell Counting And Imaging

Biocompatible, Degradable Hollow Shell Particles for High-Throughput Screening and Sorting of Cells (Case No. 2021-026)

Summary: UCLA researchers in the Department of Bioengineering have developed a microfluidic technique that can encapsulate specific cells and separate them with fluorescence cell sorters. Background: The interest in cell-derived byproducts such as recombinant therapeutic proteins and antibody therapy has increased in the past years. Typically,...

Published: 11/15/2024 | Inventor(s): Dino Di Carlo, Mark Van Zee, Joseph de Rutte, Sohyung Lee

Keywords(s): Assay, Bioassay, Cell Growth, Fluorescence, Fluorescent Labelling, High-Content Screening, High-Throughput Screening, Nanotechnology, Screening Libraries

Category(s): Life Science Research Tools, Life Science Research Tools > Screening Libraries, Life Science Research Tools > Cell Lines, Life Science Research Tools > Cell Counting And Imaging, Materials > Nanotechnology

2021-144 BIOMARKERS OF DRUG TARGET ENGAGEMENT IN CANCER

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified kinase inhibitors that block glucose consumption and for which [18F]FDG PET can be used as a biomarker, potentially aiding in the early assessment of therapeutic regimen and faster clinical trials.BACKGROUND: Pharmacodynamic biomarkers of drug efficacy...

Published: 9/5/2023 | Inventor(s): Peter Clark, Chiara Ghezzi

Keywords(s): Diagnostic Markers & Platforms, PET

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging > PET, Therapeutics > Oncology

2020-870 MULTIVARIATE BIOMIMETIC BIOMATERIAL ARRAYS FOR PRECISION MEDICINE AND SCREENING APPLICATIONS

UCLA researchers in the Department of Bioengineering have developed a novel combinational library of biomimetic hydrogels that aids in the more advanced screening for precision medicine.BACKGROUND Drug screening utilizing advanced 3D cell culture is rapidly growing in the biotech industry for its more accurate representation of human physiology...

Published: 9/12/2023 | Inventor(s): Stephanie Seidlits, Jesse Liang, Alireza Sohrabi

Keywords(s): Biomedical Engineering, Drug Development Feature Extraction, Polymer, Tissue Engineering

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers > Targets And Assays

2012-293 Compound Library Made Through Phosphine-Catalyzed Annulation/Tebbe/Diels-Alder Reaction

Summary UCLA researchers in the Department of Chemistry and Biochemistry have developed a small molecule library consisting of a large variety stereochemical variants. Background Small molecule libraries are used for high throughput screening for any biological activity. These are used for drug discovery and to investigate mechanisms of activity. However,...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Screening Libraries

1993-576 Method for Screening Delta Opioid Receptor Modulators

Summary Dr. Christopher Evans, Director of the Brain Research Institute at UCLA, and colleagues have developed a screening methodology for identifying modulators of the delta opioid recepto Background Opioid receptors are abundant in the central and peripheral nervous system and are the targets of both opiate drugs and a family of endogenous opioid...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Screening Libraries